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1.发明申请Method and identification of downstream mrna ligands to fmrp and their role in fragile x syndrome and associated disorders 失效下游mrna配体对fmrp的方法和鉴定及其在脆性x综合征及相关疾病中的作用公开(公告)号：US20050130151A1
公开(公告)日：2005-06-16
申请号：US10495728
申请日：2002-11-15
申请人： Stephen Warren , Victoria Brown-Kennerly , Peng Jin , Stephanie Ceman , Robert Darnell , Jennifer Darnell , Jack Keene , Scott Tenenbaum
发明人： Stephen Warren , Victoria Brown-Kennerly , Peng Jin , Stephanie Ceman , Robert Darnell , Jennifer Darnell , Jack Keene , Scott Tenenbaum
IPC分类号： A01K67/027 , C07H21/04 , C07K14/705 , C07K16/28 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/158
摘要： Compositions and methods for identifying and/or modulating RNA transcripts and/or genes involved in fragile X syndrome and other associated disorders are provided. In particular, RNA targets for fragile X mental retardation protein (FMRP) have been identified by a novel monoclonal antibody to FMRP and a consensus sequence for the RNA binding region has been identified. Arrays for identifying compounds, proteins, nucleotides, and the like that modulate the RNA targets or associated genes are provided. Additionally, methods for modulating RNA targets are provided.
摘要翻译： 提供了用于鉴定和/或调节涉及脆性X综合征和其它相关病症的RNA转录物和/或基因的组合物和方法。 特别地，已经通过FMRP的新型单克隆抗体鉴定了脆性X智力迟钝蛋白（FMRP）的RNA靶标，并且已经鉴定了RNA结合区域的共有序列。 提供了用于鉴定调节RNA靶标或相关基因的化合物，蛋白质，核苷酸等的阵列。 另外，提供了调节RNA靶标的方法。
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2.发明授权Method and identification of downstream mRNA ligands to FMRP and their role in fragile X syndrome and associated disorders 失效FMRP下游mRNA配体的方法和鉴定及其在脆性X综合征及相关疾病中的作用公开(公告)号：US07432052B2
公开(公告)日：2008-10-07
申请号：US10495728
申请日：2002-11-15
申请人： Stephen T. Warren , Victoria Brown-Kennerly , Peng Jin , Stephanie Ceman , Robert B. Darnell , Jennifer C. Darnell , Jack D. Keene , Scott A. Tenenbaum
发明人： Stephen T. Warren , Victoria Brown-Kennerly , Peng Jin , Stephanie Ceman , Robert B. Darnell , Jennifer C. Darnell , Jack D. Keene , Scott A. Tenenbaum
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/158
摘要： Compositions and methods for identifying and/or modulating RNA transcripts and/or genes involved in fragile X syndrome and other associated disorders are provided. In particular, RNA targets for fragile X mental retardation protein (FMRP) have been identified by a novel monoclonal antibody to FMRP and a consensus sequence for the RNA binding region has been identified. Arrays for identifying compounds, proteins, nucleotides, and the like that modulate the RNA targets or associated genes are provided. Additionally, methods for modulating RNA targets are provided.
摘要翻译： 提供了用于鉴定和/或调节涉及脆性X综合征和其它相关病症的RNA转录物和/或基因的组合物和方法。 特别地，已经通过FMRP的新型单克隆抗体鉴定了脆性X智力迟钝蛋白（FMRP）的RNA靶标，并且已经鉴定了RNA结合区域的共有序列。 提供了用于鉴定调节RNA靶标或相关基因的化合物，蛋白质，核苷酸等的阵列。 另外，提供了调节RNA靶标的方法。
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公开(公告)号：US20120023599A1
公开(公告)日：2012-01-26
申请号：US12842943
申请日：2010-07-23
IPC分类号： G01N33/48 , C07H21/04 , C12N9/16 , A01K67/027 , C12N5/07
CPC分类号： C12N9/16 , A01K67/0275 , A01K67/0278 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N9/0083
摘要： The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding cytochrome P450 (CYP) proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequence encoding CYP proteins, as well as methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects.
摘要翻译： 本发明提供了经编码的动物和细胞，其包含编辑细胞色素P450（CYP）蛋白的编辑的染色体序列。 特别地，使用锌指核酸酶介导的编辑过程产生动物或细胞。 本发明还提供靶向编码CYP蛋白的染色体序列的锌指核酸酶，以及使用本文公开的遗传修饰的动物或细胞筛选药物的毒性和其它作用的方法。
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