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    Method and illumination system for simulating CIE standard illuminant with multi-channel LED
    3.
    发明授权
    Method and illumination system for simulating CIE standard illuminant with multi-channel LED 有权

    公开(公告)号：US11388794B2

    公开(公告)日：2022-07-12

    申请号：US17382234

    申请日：2021-07-21

    申请人： Peng Jin

    发明人： Peng Jin

    IPC分类号： H05B45/14 ,  H05B45/28 ,  H05B45/24 ,  F21K9/64 ,  F21Y115/10

    摘要： A method and an illumination system for simulating a CIE standard illuminant with a multi-channel LED are disclosed. The method includes adjusting a brightness of the main light source control channel, the wavelength complementary control channel, the color temperature adjustment control channel to make a mixed chromaticity coordinate meet a chromaticity coordinate of the CIE standard illuminant to be simulated according to chromaticity coordinates. The LED control channels are reduced through group optimization, and a technology which is discarded by multi-channel LED such as a filter is used, a control of a light source substantially reducing number of control channels and enabling a multi-channel LED to simulate a standard illuminant is formed, such that a single chromaticity control rather than a chromaticity control which must be transformed by a spectral conversion is achieved.

    Method for Directed DNA Evolution using Combinatorial DNA Libraries
    6.
    发明申请
    Method for Directed DNA Evolution using Combinatorial DNA Libraries 审中-公开
    使用组合DNA文库进行定向DNA进化的方法

    公开(公告)号：US20160319272A1

    公开(公告)日：2016-11-03

    申请号：US15140408

    申请日：2016-04-27

    申请人： Zhen Kang ,  Jian Chen ,  Guocheng Du ,  Peng Jin

    发明人： Zhen Kang ,  Jian Chen ,  Guocheng Du ,  Peng Jin

    IPC分类号： C12N15/10

    CPC分类号： C12N15/1058 ,  C12N15/1031 ,  C12Q2521/101 ,  C12Q2521/501 ,  C12Q2531/113 ,  C12Q2533/101 ,  C12Q2563/179

    摘要： The present invention provides a method of rapid directed DNA evolution based on single-stranded combinatorial DNA mutant library. The single- and double-stranded mutant library are constructed either separately or simultaneously using editing primers that contain mutated nucleotides and are targeted to different regions of the parent DNA sequence. The mutant library is then inserted into expression vectors and mutants with desired property are obtained by high throughput screening. Evolution of promoters, enzymes and metabolic pathways were successfully achieved using this method and mutants with excellent properties were obtained. The method of the present invention is simple, rapid, and efficient. It can be used for directed evolution of regulatory sequence such as promoters and ribosome binding sites, and is especially suitable for introducing diverse mutations into protein encoding genes, leading to rapid directed evolution of gene of interest.

    摘要翻译： 本发明提供了基于单链组合DNA突变体文库的快速定向DNA进化的方法。 使用含有突变核苷酸的编辑引物单独或同时构建单链和双链突变体文库，并且靶向母DNA序列的不同区域。 然后将突变型文库插入表达载体中，并通过高通量筛选获得具有所需性质的突变体。 使用该方法成功实现了启动子，酶和代谢途径的进化，获得了具有优异性能的突变体。 本发明的方法简单，快速，高效。 它可以用于调节序列的定向进化，如启动子和核糖体结合位点，特别适用于将多种突变引入到蛋白质编码基因中，导致感兴趣的基因的快速定向进化。

    COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST
    7.
    发明申请
    COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST 审中-公开
    用于调节多焦点的沉降的化合物和方法

    公开(公告)号：US20120071539A1

    公开(公告)日：2012-03-22

    申请号：US12519062

    申请日：2007-12-12

    申请人： Peng Jin

    发明人： Peng Jin

    IPC分类号： A61K31/713 ,  A61K31/4439 ,  A61K31/352 ,  A61K31/575 ,  A61K31/192 ,  A61K31/366 ,  A61K31/16 ,  A61K31/52 ,  A61K31/357 ,  A61K31/395 ,  A61K31/4985 ,  A61K31/7105 ,  A61K8/60 ,  A61K31/365 ,  A61P31/12 ,  A61P43/00 ,  A61K31/496 ,  C12Q1/68 ,  C40B30/06 ,  A61K31/444 ,  A61K31/4409 ,  A61P35/00 ,  A61P35/02 ,  A61P25/28 ,  A61P25/16 ,  C12N5/071

    CPC分类号： A61K31/4439

    摘要： Methods and compositions comprising chemical compounds that modulate the silencing of a polynucleotide of interest in a cell are provided. Such chemical compounds when used in combination with an appropriate silencing element can be used to modulate (increase or decrease) the level of the polynucleotide targeted by the silencing element. Methods of using such compositions both in therapies involving RNAi-mediated suppression of gene expression, as well as, in vitro methods that allow for the targeted modulation of expression of a polynucleotide of interest are provided. Pharmaceutical or cosmetic compositions comprising such compounds and silencing elements also are disclosed. Methods for screening a compound of interest for the ability to modulate the activity of a heterologous silencing element also are provided.

    摘要翻译： 提供了包含调节细胞中目的多核苷酸沉默的化合物的方法和组合物。 当与适当的沉默元件组合使用时，这种化合物可用于调节（增加或减少）沉默元件靶向的多核苷酸的水平。 提供了在涉及RNAi介导的基因表达抑制的治疗中使用这些组合物的方法，以及允许针对目的调节感兴趣的多核苷酸表达的体外方法。 还公开了包含这些化合物和沉默元件的药物或化妆品组合物。 还提供了筛选感兴趣的化合物调节异源沉默元件的活性能力的方法。

    Lithographic process
    8.
    发明授权
    Lithographic process 失效
    平版印刷工艺

    公开(公告)号：US07910292B2

    公开(公告)日：2011-03-22

    申请号：US10582033

    申请日：2004-12-01

    申请人： Kyle Jiang ,  Peng Jin

    发明人： Kyle Jiang ,  Peng Jin

    IPC分类号： G03F7/00

    CPC分类号： G03F7/2008 ,  G03F7/20

    摘要： The present invention provides a lithographic process for producing high aspect ratio parts from an epoxy-type negative photoresist comprising the steps of: (i) irradiating a prebaked masked epoxy-type negative photoresist on a substrate with light at a total energy density of from 18,000 to 35,000 mJ/cm2, (ii) post-baking the exposed photoresist at elevated temperature, and (iii) developing the exposed photoresist in a solvent, wherein no more than 15% of the energy density is contributed by light having a wavelength of 400 nm or less. The invention also discloses a reciprocating microengine (10) comprising a cylinder (14), piston (12) and crankshaft made by the process.

    摘要翻译： 本发明提供了一种用于从环氧型负型光致抗蚀剂制造高纵横比部件的光刻工艺，其特征在于包括以下步骤：（i）在总能量密度为18,000的光照射基底上的预焙掩膜的环氧型负性光致抗蚀剂 （iii）在升高的温度下对曝光的光致抗蚀剂进行后烘烤，以及（iii）在溶剂中显影曝光的光致抗蚀剂，其中不超过15％的能量密度由波长为400的光 nm以下。 本发明还公开了一种往复式微发动机（10），其包括由该过程制成的气缸（14），活塞（12）和曲轴。

    LED light bulb
    9.
    发明申请
    LED light bulb 失效
    LED灯泡

    公开(公告)号：US20060215422A1

    公开(公告)日：2006-09-28

    申请号：US11343450

    申请日：2006-01-30

    申请人： Robert Laizure ,  Wojciech Pawelko ,  Lee Cote ,  Peng Jin

    发明人： Robert Laizure ,  Wojciech Pawelko ,  Lee Cote ,  Peng Jin

    IPC分类号： H01R33/00 ,  F21V31/00

    CPC分类号： F21V31/005 ,  F21K9/232 ,  F21V3/00 ,  F21Y2107/00 ,  F21Y2107/90 ,  F21Y2115/10 ,  Y10S362/80

    摘要： A light emitting diode (LED) light bulb configured to replicate the light output of a conventional incandescent light bulb is provided. The LED light bulb includes a base for coupling the bulb to a power source having at least one side wall defining a cavity; a generally rectangular substrate having a first end and a second end, the second end disposed in the cavity and electrically coupled to the base; a plurality of LEDs electrically coupled and disposed on the first end of the substrate, the plurality of LEDS arranged on a front face, back face and top edge of the first end of the substrate to emit light in a spherical output; and a light transmissive cover configured to enclose the plurality of LEDs, the cover being coupled to the base.

    摘要翻译： 提供了配置成复制常规白炽灯泡的光输出的发光二极管（LED）灯泡。 LED灯泡包括用于将灯泡耦合到具有限定空腔的至少一个侧壁的电源的基座; 具有第一端和第二端的大致矩形的基板，所述第二端设置在所述空腔中并电耦合到所述基座; 电耦合并设置在所述基板的第一端上的多个LED，所述多个LED布置在所述基板的第一端的前表面，背面和顶边缘上以发射球形输出的光; 以及被配置为包围所述多个LED的透光盖，所述盖耦合到所述基座。

    Massage gun
    10.
    外观设计
    Massage gun 有权

    公开(公告)号：USD982171S1

    公开(公告)日：2023-03-28

    申请号：US29811835

    申请日：2021-10-18

    申请人： Peng Jin

    设计人： Peng Jin