公开(公告)号：US20130225998A1

公开(公告)日：2013-08-29

申请号：US13407378

申请日：2012-02-28

申请人： Stergios Stergiopoulos ,  Andreas Freibert ,  Jason Zhang

发明人： Stergios Stergiopoulos ,  Andreas Freibert ,  Jason Zhang

IPC分类号： A61B8/08

CPC分类号： A61B8/0808 ,  A61B5/4064 ,  A61B8/0858 ,  G01N2291/048

摘要： Described herein is the use of ultrasound pulses at different frequencies to track the dispersion properties of intracranial tissues which may have been altered due to traumatic or other neurological brain injury. Dispersive ultrasound does not provide imaging, but it can provide data of significant diagnostic value by using decision support systems that can be trained as a medical diagnostic system for traumatic brain injuries applications to detect specific patterns of dispersion that are associated with specific intracranial injuries.

摘要翻译： 这里描述的是使用不同频率的超声波脉冲跟踪可能由于创伤性或其他神经性脑损伤而改变的颅内组织的分散性质。 分散超声不提供成像，但它可以通过使用可被训练为创伤性脑损伤应用的医学诊断系统的检测支持系统来提供具有显着诊断价值的数据，以检测与特定颅内损伤相关的特定分散模式。

公开(公告)号：US08834376B2

公开(公告)日：2014-09-16

申请号：US13407378

申请日：2012-02-28

申请人： Stergios Stergiopoulos ,  Andreas Freibert ,  Jason Zhang

发明人： Stergios Stergiopoulos ,  Andreas Freibert ,  Jason Zhang

IPC分类号： A61B8/00 ,  A61B8/08 ,  A61B5/00

CPC分类号： A61B8/0808 ,  A61B5/4064 ,  A61B8/0858 ,  G01N2291/048

摘要： Described herein is the use of ultrasound pulses at different frequencies to track the dispersion properties of intracranial tissues which may have been altered due to traumatic or other neurological brain injury. Dispersive ultrasound does not provide imaging, but it can provide data of significant diagnostic value by using decision support systems that can be trained as a medical diagnostic system for traumatic brain injuries applications to detect specific patterns of dispersion that are associated with specific intracranial injuries.

摘要翻译： 这里描述的是使用不同频率的超声波脉冲跟踪可能由于创伤性或其他神经性脑损伤而改变的颅内组织的分散性质。 分散超声不提供成像，但它可以通过使用可被训练为创伤性脑损伤应用的医学诊断系统的检测支持系统来提供具有显着诊断价值的数据，以检测与特定颅内损伤相关的特定分散模式。

公开(公告)号：US06894494B2

公开(公告)日：2005-05-17

申请号：US10608141

申请日：2003-06-30

申请人： Stergios Stergiopoulos ,  Miroslaw Wrobel ,  Andreas Freibert ,  Waheed Younis ,  Amar Dhanantwari

发明人： Stergios Stergiopoulos ,  Miroslaw Wrobel ,  Andreas Freibert ,  Waheed Younis ,  Amar Dhanantwari

IPC分类号： G01R33/567 ,  G01V3/00

CPC分类号： G01R33/5673 ,  G01R33/56325

摘要： The present invention relates to a signal processing method and system for correcting organ motion artifacts for cardiac and brain imaging. A plurality of sets of MRI measurement data indicative of at least an image of an object is received. Each set corresponds to one row kx of a k-space matrix of at least a k-space matrix. For each set a k-space matrix of the at least a k-space matrix is determined for allocation thereto based on motion information of the object occurring during acquisition of the plurality of sets of the MRI measurement data. In a following step a location within the allocated k-space matrix corresponding to a row of the k-space matrix allocated thereto is determined for each set. At least a k-space matrix is then generated by re-arranging the plurality of sets. Each of the at least a k-space matrix comprises the sets of the plurality of sets of the MRI measurement data allocated thereto. Inverse Fourier transforming of the plurality of k-space matrices provides at least a reconstructed image. Through careful selection of the phases of the cardiac and respiratory cycles and corresponding ranges MRI data acquisition periods are of the order of seconds or a few minutes. Furthermore, integration of motion artifact free MRI images of different phases of organ motion using the coherent k-space synthesis according to the invention allows provision of an animation showing different phases of a cardiac or lung cycle. In an embodiment for correcting motion artifacts for brain imaging a motion vector describing translational and rotational motion of a patient's head is tracked during the MRI data acquisition process. The motion artifacts are then corrected based on coherent k-space synthesis using the motion vector data.

摘要翻译： 本发明涉及用于校正心脏和脑成像的器官运动假象的信号处理方法和系统。 接收指示对象的至少一个图像的多组MRI测量数据。 每个集合对应于至少一个k空间矩阵的k空间矩阵的一行k×××。 对于每个集合，基于在获取多组MRI测量数据的采集期间发生的对象的运动信息，确定至少k空间矩阵的k空间矩阵用于分配。 在随后的步骤中，针对每个集合确定与分配给其的k空间矩阵的行相对应的所分配的k空间矩阵内的位置。 然后，通过重新排列多个集合来生成至少一个k空间矩阵。 所述至少k空间矩阵中的每一个包括分配给其的所述多个MRI测量数据的集合。 多个k空间矩阵的逆傅立叶变换提供至少一个重构图像。 通过仔细选择心脏和呼吸周期的相位和相应范围，MRI数据采集周期大约为数秒或数分钟。 此外，使用根据本发明的相干k空间合成的器官运动的不同阶段的运动伪像自由MRI图像的集成允许提供显示心脏或肺循环的不同阶段的动画。 在用于校正脑成像的运动伪像的实施例中，描述了在MRI数据采集过程期间描述患者头部的平移和旋转运动的运动矢量。 然后基于使用运动矢量数据的相干k空间合成校正运动假象。

公开(公告)号：US06805671B2

公开(公告)日：2004-10-19

申请号：US10342277

申请日：2003-01-15

申请人： Stergios Stergiopoulos ,  Amar Dhanantwari ,  Lisa Pinto ,  Ronald Zachariah ,  Man Yee Winnie Wong

发明人： Stergios Stergiopoulos ,  Amar Dhanantwari ,  Lisa Pinto ,  Ronald Zachariah ,  Man Yee Winnie Wong

IPC分类号： A61B502

CPC分类号： A61B5/02208 ,  A61B5/025 ,  A61B7/045

摘要： A method and a device for measuring blood pressure and heart rate in an environment comprising extreme levels of noise and vibrations is disclosed. Blood pressure signals corresponding to the Korotkoff sounds are detected using an array of primary acoustic sensors, placed on the patient's skin over the brachial artery. A secondary acoustic transducer is placed on the outside of a pressure cuff the patient away for detecting noise and vibrations. Pressure is applied to the artery using the pressure cuff forcing the artery to close. The pressure is then reduced and while reducing the pressure the acoustic signals detected by the first and second acoustic sensor as well as a signal indicative of the pressure applied to the artery are provided to a processor. The signals provided by the primary acoustic sensors are then processed using a combination of focused beamforming and planar wave beamforming. The final beam time series is then processed using an adaptive interferer canceller algorithm with the signal provided by the secondary acoustic sensor as interferer. Use of an array of acoustic sensors in combination with beamforming substantially enhances signal detection as well as accurate isolation of the signal source which is highly beneficial for blood pressure measurements measurements performed under extreme levels of noise and vibrations.

摘要翻译： 公开了一种用于在包括极高水平的噪声和振动的环境中测量血压和心率的方法和装置。 使用放置在肱动脉上的患者皮肤上的主要声学传感器阵列来检测对应于Korotkoff声音的血压信号。 辅助声换能器放置在患者远离的压力袖带的外侧，用于检测噪声和振动。 使用压力袖带迫使动脉闭合，向动脉施加压力。 然后降低压力并且在降低压力的同时，将由第一和第二声学传感器检测的声学信号以及指示施加到动脉的压力的信号提供给处理器。 然后，使用聚焦波束形成和平面波束形成的组合来处理由主声传感器提供的信号。 然后使用自适应干扰消除器算法来处理最终光束时间序列，其中由第二声传感器提供的信号作为干扰源。 使用声波传感器阵列与波束成形技术相结合，可显着增强信号检测以及信号源的准确隔离，这对于在极高噪声和振动水平下进行的血压测量测量非常有益。

公开(公告)号：US06482160B1

公开(公告)日：2002-11-19

申请号：US09718516

申请日：2000-11-24

申请人： Stergios Stergiopoulos ,  Amar C. Dhanantwari

发明人： Stergios Stergiopoulos ,  Amar C. Dhanantwari

IPC分类号： A61B800

CPC分类号： G01S15/8927 ,  G01S7/52046 ,  G01S15/8929 ,  G01S15/8993 ,  G10K11/346 ,  Y10S128/916

摘要： An adaptive multidimensional beamformer having near-instantaneous convergence for ultrasound imaging systems deploying multidimensional sensor arrays is disclosed. In a first step, the multidimensional beamformer is decomposed into sub-apertures. Each sub-aperture is then again decomposed into two coherent subsets of circular and/or line array beamformers in different coordinate directions of the multidimensional array. Implementation of the multidimensional beamformer according to the present invention provides the basis for a 3D ultrasound imaging system according to the present invention comprising a compact multidimensional sensor array and a compact processing unit that is field deployable and generates high resolution three-dimensional images in real time. It is also possible to capture four-dimensional images, the fourth dimension being time and the resulting images forming a video image of a volume of a moving organ.

摘要翻译： 公开了一种对于部署多维传感器阵列的超声成像系统具有近瞬间会聚的自适应多维波束形成器。 在第一步骤中，多维波束形成器被分解为子孔径。 然后，每个子孔径再分解成在多维阵列的不同坐标方向上的圆形和/或线阵列波束形成器的两个相干子集。 根据本发明的多维波束形成器的实现为根据本发明的3D超声波成像系统提供了基础，其包括紧凑的多维传感器阵列和紧凑的处理单元，该处理单元是现场可部署的并且实时生成高分辨率三维图像 。 也可以捕获四维图像，第四维是时间，并且所得到的图像形成移动器官的体积的视频图像。

公开(公告)号：US06543933B2

公开(公告)日：2003-04-08

申请号：US10046547

申请日：2002-01-16

申请人： Stergios Stergiopoulos ,  Nikolaos Uzunoglu

发明人： Stergios Stergiopoulos ,  Nikolaos Uzunoglu

IPC分类号： A61B505

CPC分类号： A61B5/015 ,  A61B5/0507 ,  A61B5/4064 ,  G01K11/006

摘要： A microwave thermography apparatus to measure temperatures within a dielectric body comprises a partial ellipsoidal cavity with an electrical conductive surface wherein the body can be located at one focus of the cavity. A microwave antenna located at a second focus of the cavity is connected to a radiometer. That radiometer amplifies and filters signals from the antenna before they are applied to a detector with the temperature of the body being determined from the voltage amplitude of the detected signals.

公开(公告)号：US06535570B2

公开(公告)日：2003-03-18

申请号：US09773925

申请日：2001-02-02

申请人： Stergios Stergiopoulos ,  Amar C. Dhanantwari

发明人： Stergios Stergiopoulos ,  Amar C. Dhanantwari

IPC分类号： A61B603

CPC分类号： G06T5/50 ,  A61B6/583 ,  Y10S378/901

摘要： A method of tracking organ motion and removing motion artifacts in conventional computer tomography scans is disclosed. Sensor time series indicative of projection measurement data of the object are correlated using a software spatial overlap correlator method in order to obtain a sinogram indicative of organ motion. The software spatial overlap correlator method is based on the fact that the image sampling process of a computer tomography scanner is periodical, therefore, image samples taken at a time t and at a time t+T are taken from identical spatial locations. The sinogram is then processed using a retrospective gating method or a coherent sinogram synthesis method in order to correct the image data for motion effects. This method for motion correction is software based and, therefore, can be easily implemented in existing computer tomography systems without major hardware modification.

公开(公告)号：US20060253040A1

公开(公告)日：2006-11-09

申请号：US11356958

申请日：2006-02-21

申请人： Stergios Stergiopoulos ,  Dimitrios Hatzinakos

发明人： Stergios Stergiopoulos ,  Dimitrios Hatzinakos

IPC分类号： A61B5/02

CPC分类号： A61B5/02208 ,  A61B5/7207 ,  A61B5/7239 ,  A61B7/045

摘要： A method and a device for measuring blood pressure and heart rate is disclosed. Blood pressure signals corresponding to the Korotkoff sounds are detected using an array of primary acoustic sensors. A secondary acoustic sensor is used for detecting noise and vibrations. The signals provided by the primary acoustic sensors are then processed using adaptive linear beamforming and are combined into a single signal. The combined signal is then provided to an adaptive interferer canceller together with the signal of the secondary acoustic sensor for removing noise and vibration effects. Artifacts due to a patient's motion are removed in a following post-processing step. The post-processed signal and the pressure signal are then graphically displayed enabling a trained user to correct the automatic measurement, to decide whether a repeat measurement is necessary, and to quickly and accurately diagnose heart pulse patterns.

摘要翻译： 公开了一种用于测量血压和心率的方法和装置。 使用主要声学传感器阵列来检测对应于Korotkoff声音的血压信号。 二次声传感器用于检测噪声和振动。 然后由主要声学传感器提供的信号使用自适应线性波束形成进行处理，并且被组合成单个信号。 然后将组合的信号与辅助声传感器的信号一起提供给自适应干扰消除器，以消除噪声和振动效应。 在后续处理步骤中移除由于患者运动引起的人工制品。 后处理信号和压力信号然后被图形显示，使训练有素的用户能够校正自动测量，以确定是否需要重复测量，以及快速准确地诊断心脏脉搏模式。

公开(公告)号：US06719696B2

公开(公告)日：2004-04-13

申请号：US10273951

申请日：2002-10-21

申请人： Stergios Stergiopoulos ,  Amar C. Dhanantwari

发明人： Stergios Stergiopoulos ,  Amar C. Dhanantwari

IPC分类号： A61B800

CPC分类号： G01S15/8927 ,  G01S7/52046 ,  G01S15/8929 ,  G01S15/8993 ,  G10K11/346 ,  Y10S128/916

摘要： An adaptive multidimensional beamformer having near-instantaneous convergence for ultrasound imaging systems deploying multidimensional sensor arrays is disclosed. In a first step, the multidimensional beamformer is decomposed into sub-apertures. Each sub-aperture is then again decomposed into two coherent subsets of circular and/or line array beamformers in different coordinate directions of the multidimensional array. Implementation of the multidimensional beamformer according to the present invention provides the basis for a 3D ultrasound imaging system according to the present invention comprising a compact multidimensional sensor array and a compact processing unit that is field deployable and generates high resolution three-dimensional images in real time. It is also possible to capture four-dimensional images, the fourth dimension being time and the resulting images forming a video image of a volume of a moving organ.

摘要翻译： 公开了一种对于部署多维传感器阵列的超声成像系统具有近瞬间会聚的自适应多维波束形成器。 在第一步骤中，多维波束形成器被分解为子孔径。 然后，每个子孔径再分解成在多维阵列的不同坐标方向上的圆形和/或线阵列波束形成器的两个相干子集。 根据本发明的多维波束形成器的实现为根据本发明的3D超声波成像系统提供了基础，其包括紧凑的多维传感器阵列和紧凑的处理单元，该处理单元是可现场部署的并且实时生成高分辨率三维图像 。 也可以捕获四维图像，第四维是时间，并且所得到的图像形成移动器官的体积的视频图像。

公开(公告)号：US06705998B2

公开(公告)日：2004-03-16

申请号：US10133575

申请日：2002-04-29

申请人： Stergios Stergiopoulos ,  Amar Dhanantwari ,  Lisa Pinto ,  Ronald Zachariah

发明人： Stergios Stergiopoulos ,  Amar Dhanantwari ,  Lisa Pinto ,  Ronald Zachariah

IPC分类号： A61B502

CPC分类号： A61B5/02208 ,  A61B5/022 ,  A61B5/025 ,  A61B7/045

摘要： A method and a device for measuring systolic and diastolic blood pressure and heart rate in an environment comprising extreme levels of noise and vibrations is disclosed. Blood pressure signals corresponding to the Korotkoff sounds are detected using a first acoustic sensor, or array of sensors, placed on the patient's skin over the brachial artery. A second acoustic transducer is placed on the outside of a pressure cuff the patient away for detecting noise and vibrations. Pressure is applied to the artery using the pressure cuff forcing the artery to close. The pressure is then reduced and while reducing the pressure the acoustic signals detected by the first and second acoustic sensor as well as a signal indicative of the pressure applied to the artery are provided to a processor. The signal of the first acoustic sensor is then processed using an adaptive interferer canceller algorithm with the signal of the second acoustic sensor as interferer. From the processed signal heart beat pulses are determined and relating the heart beat pulses to the pressure signal provides the systolic and diastolic blood pressure. Use of the adaptive interferer canceller provides good results for measurements performed under extreme levels of noise and vibrations such as aboard a helicopter, naval vessels, ambulances and noisy emergency rooms.

摘要翻译： 公开了一种用于在包括极端噪声和振动的环境中测量收缩和舒张压和心率的方法和装置。 使用放置在肱动脉上的患者皮肤上的第一声传感器或传感器阵列检测对应于Korotkoff声音的血压信号。 将第二声换能器放置在患者远离的压力袖带的外侧以检测噪声和振动。 使用压力袖带迫使动脉闭合，向动脉施加压力。 然后降低压力并且在降低压力的同时，将由第一和第二声学传感器检测的声学信号以及指示施加到动脉的压力的信号提供给处理器。 然后使用具有第二声传感器的信号作为干扰源的自适应干扰消除器算法来处理第一声传感器的信号。 从经处理的信号中，确定心搏脉冲并将心跳脉搏与压力信号相关联，提供收缩压和舒张压。 自适应干扰消除器的使用对于在诸如直升机，海军舰艇，救护车和嘈杂的急诊室之间的极端噪音和振动水平下进行的测量提供了良好的结果。