-
1.发明申请Treatment of lesions or imperfections in skin, near-skin or in other anatomic tissues, including under direct visualization 审中-公开治疗皮肤，近皮肤或其他解剖组织中的损伤或缺陷，包括直接观察公开(公告)号：US20100074407A1
公开(公告)日：2010-03-25
申请号：US12284289
申请日：2008-09-19
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61N5/1001 , A61N2005/1091 , A61N2005/1094 , A61N2005/1095
摘要： An apparatus and method for treatment of lesions or imperfections in or near exposed anatomic surfaces using low-level ionizing radiation includes a substantially transparent applicator to administer radiation from an energy source to a surface area with the lesion. The applicator is positioned over the lesion to be treated, a treatment plan is created to achieve the desired therapeutic effect to the lesion, and execution of the treatment plan is executed by the energy source. Verification of the treatment to plan and safety methods are disclosed.
摘要翻译： 用于使用低级电离辐射治疗暴露的解剖表面内或附近的损伤或缺陷的装置和方法包括基本上透明的施用器，以将能量源的辐射施加到具有损伤的表面区域。 施用器位于要治疗的病变上，创建治疗计划以实现对病变的期望的治疗效果，并且由能量源执行治疗计划的执行。 公开了对计划和安全方法的处理的验证。
-
公开(公告)号：US07127033B2
公开(公告)日：2006-10-24
申请号：US10789653
申请日：2004-02-28
申请人： Paul A. Lovoi , John Rieke , Alex Lim , Peter C. Smith , Thomas W. Rusch
发明人： Paul A. Lovoi , John Rieke , Alex Lim , Peter C. Smith , Thomas W. Rusch
IPC分类号： H01J35/32
CPC分类号： A61N5/1002 , A61M25/003 , A61M25/10 , A61M2025/0004 , A61M2025/0034 , A61M2025/0036 , A61M2025/0039 , A61N2005/005 , A61N2005/1022 , H01J35/32 , H01J2235/1216 , H01J2235/122 , H01J2235/1262 , H05G1/025
摘要： A miniature x-ray tube is cooled using a catheter preferably having multiple small lumens for inflow and outflow of coolant. Inflow may be through an outer lumen(s) in a concentric-extrusion catheter, the liquid turning back at the distal end of the catheter to a proximal flow over the anode end of the x-ray tube and through an inner lumen within which the x-ray tube is positioned. A coolant distribution head may engage with the anode end of the x-ray tube, with small orifices so as to distribute coolant essentially evenly over the anode surface. Temperature and flow rate of the inflowing coolant liquid are balanced so as to optimize heat transfer while efficiently carrying coolant through small lumens without the need for high pressures. Some embodiments use the inflation liquid in an applicator balloon as the coolant, with the liquid actively flowing or, in a simplified system, with the liquid static.
摘要翻译： 使用优选具有用于冷却剂的流入和流出的多个小流明的导管来冷却微型X射线管。 流入可以穿过同心挤出导管中的外腔，液体在导管的远端处返回到X射线管的阳极端上的近端流动并且穿过内腔，在内腔内 x射线管被定位。 冷却剂分配头可以与X射线管的阳极端接合，具有小孔，以便将冷却剂基本均匀地分布在阳极表面上。 流入的冷却剂液体的温度和流速是平衡的，以便优化热传递，同时有效地将冷却剂携带在小流明中，而不需要高压。 一些实施例使用施用器气囊中的充气液体作为冷却剂，其中液体主动地流动，或者在简化的系统中使液体静止。
-
公开(公告)号：US07885382B2
公开(公告)日：2011-02-08
申请号：US11820238
申请日：2007-06-18
IPC分类号： G21K5/00
CPC分类号： A61N5/1015 , A61B90/39 , A61B2017/22051 , A61B2090/3933 , A61N2005/1003 , A61N2005/1061
摘要： Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
摘要翻译： 描述了用于通过空腔或内腔照射活组织的方法和装置，使用可充气球囊施放器。 在优选实施例中，施放器气球具有具有相对较低浓度的x射线造影材料的气球皮肤，使得当从外部成像时气球的轮廓将显现出明显。 在另一个优选实施例中，球囊导管具有用于从空腔抽出液体的排水口，其可以包括气囊外部上的通道或纹理。 描述了使用可变形的微型X射线管的方法，其可变电压和电流，以获得等剂量曲线的精度。
-
公开(公告)号：US07783006B2
公开(公告)日：2010-08-24
申请号：US10962247
申请日：2004-10-08
IPC分类号： G21K5/00
CPC分类号： A61N5/1015 , A61B90/39 , A61B2017/22051 , A61B2090/3933 , A61N2005/1003 , A61N2005/1061
摘要： Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
摘要翻译： 描述了用于通过空腔或内腔照射活组织的方法和装置，使用可充气球囊施放器。 在优选实施例中，施放器气球具有具有相对较低浓度的x射线造影材料的气球皮肤，使得当从外部成像时气球的轮廓将显现出明显。 在另一个优选实施例中，球囊导管具有用于从空腔抽出液体的排水口，其可以包括气囊外部上的通道或纹理。 描述了使用可变形的微型X射线管的方法，其可变电压和电流，以获得等剂量曲线的精度。
-
公开(公告)号：US07158612B2
公开(公告)日：2007-01-02
申请号：US10371401
申请日：2003-02-21
CPC分类号： H01J35/08 , H01J35/32 , H01J2235/081 , H01J2235/087 , H01J2235/164
摘要： A miniature x-ray tube has an anode assembly capable of transmitting x-rays through the anode and over a wide angular range. The anode is in the shape of a cone or truncated cone with an axis on the x-ray tube frame axis, formed of low-Z material with high thermal conductivity for heat dissipation. A target material on the anode body is in a thin layer, which may be approximately 0.5 to 5 microns thick. In one embodiment a tube evacuation exhaust port at the tail end of the anode assembly forms a cavity for a getter, with a pinched-off tubulation at the end of the cavity.
摘要翻译： 微型x射线管具有能够通过阳极透射x射线并且在宽角度范围内的阳极组件。 阳极呈圆锥形或截锥形，X射线管框架轴上具有轴，由具有高导热性的低Z材料形成，用于散热。 阳极体上的目标材料为薄层，其厚度可为约0.5至5微米。 在一个实施例中，在阳极组件的尾端处的排气排气口形成用于吸气剂的空腔，在空腔的端部处具有夹断的管道。
-
公开(公告)号：US20100127181A1
公开(公告)日：2010-05-27
申请号：US12321593
申请日：2009-01-21
申请人： Paul A. Lovoi , Steve Axelrod
发明人： Paul A. Lovoi , Steve Axelrod
IPC分类号： G01T1/02
摘要： A radiation sensor array is carried on a flexible sheet of film, for placement on the skin of a patient adjacent to a brachytherapy location beneath the skin. With the array approximately centered on a position where radiation source to skin distance is estimated to be minimum, the array of sensors is used to monitor radiation dose received at the skin. With a controller connected to the array and preferably also to the radiation source in the applicator, the radiation dose received at all skin points of interest can be monitored, a point of maximum dose and a projected approach to limit dose can be calculated, and in response the system can warn the operator or control a brachytherapy procedure so as to discontinue radiation or control the radiation level or source position in real time. The system can also include percutaneous sensors.
摘要翻译： 辐射传感器阵列承载在柔性薄膜片上，用于放置在与皮肤附近的近距离放射治疗位置相邻的患者的皮肤上。 以阵列为中心，辐射源至皮肤距离估计为最小的位置，传感器阵列用于监测皮肤接收的辐射剂量。 通过将控制器连接到阵列并且优选地也连接到施用器中的辐射源，可以监测在所有皮肤感兴趣点处接收的辐射剂量，可以计算最大剂量点和限制剂量的预计接近点，并且在 响应系统可以警告操作者或控制近距离放射治疗程序，以便实时中止辐射或控制辐射水平或源位置。 该系统还可以包括经皮传感器。
-
公开(公告)号：US09055972B2
公开(公告)日：2015-06-16
申请号：US13291854
申请日：2011-11-08
申请人： Steve Axelrod , Robert R. Burnside , Paul A. Lovoi
发明人： Steve Axelrod , Robert R. Burnside , Paul A. Lovoi
CPC分类号： A61B19/40 , A61B90/04 , A61B2090/0436 , A61N5/1001 , A61N2005/1094
摘要： Attenuating masks for selective attenuation of radiation, particularly from an x-ray source in brachytherapy, employ materials having atomic number in a specific range, so as to attenuate radiation dose intensity generally proportionally through a range of distance from the source. Some preferred attenuation materials are silver and molybdenum. A set of small masks can be provided for a particular design of catheter that holds a radiation source, each mask having a size and shape to define a different solid angle of masking, so that in a brachytherapy procedure, sensitive tissue such as bone or skin can be protected by proper selection of and positioning of the attenuating mask, to reduce the dose intensity to that tissue.
摘要翻译： 用于选择性衰减辐射的衰减掩模，特别是来自近距离放射治疗中的X射线源，使用具有特定范围内的原子序数的材料，以便通过成比例的方式衰减辐射剂量强度，从而远离源的距离。 一些优选的衰减材料是银和钼。 可以为保持辐射源的导管的特定设计提供一组小的掩模，每个掩模具有尺寸和形状以限定不同的立体角度掩蔽，使得在近程放射治疗程序中，诸如骨骼或皮肤的敏感组织 可以通过适当选择和定位衰减掩模来保护，以减少对该组织的剂量强度。
-
8.发明申请Method and apparatus for modifying distance from a brachytherapy radiation source to sensitive anatomical structures 有权用于修改从近距离放射治疗辐射源到敏感解剖结构的距离的方法和装置公开(公告)号：US20090030258A1
公开(公告)日：2009-01-29
申请号：US11881835
申请日：2007-07-28
申请人： Steve Axelrod , James E. Jervis , Paul A. Lovoi
发明人： Steve Axelrod , James E. Jervis , Paul A. Lovoi
IPC分类号： A61M36/06
CPC分类号： A61M25/1011 , A61B2017/22069 , A61M25/1002 , A61M2025/1061 , A61N5/1015
摘要： A balloon brachytherapy applicator has either a single or double chambers, with the capability of “blistering” outwardly at a specified area on one side of the balloon. This is useful to move sensitive tissue, such as skin or bone, farther away from a radiation source within a source guide inside the balloon. In one case a secondary balloon or secondary compartment is formed on the primary balloon, and is separately inflatable so as to allow blistering as desired when needed. In another form the balloon comprises a single chamber, primarily of inelastic or fairly rigidly elastic wall material, but with a “window” or area in which the balloon wall is elastic, or substantially more elastic than the main balloon wall, so that inflation of the balloon up to a certain point forms a substantially regular balloon shape (which may be approximately spherical), and the addition of further pressure will blister out the elastic area to increase the distance between the shaft and the sensitive tissue in a desired orientation of the balloon.
摘要翻译： 气球近距离放射治疗器具有单室或双室，在气球一侧的指定区域处具有“起泡”的能力。 这对于将敏感组织（例如皮肤或骨骼）移动离气囊内的源引导件内的辐射源更远是有用的。 在一种情况下，次级球囊或次级隔室形成在主气囊上，并且可分开地充气，以便在需要时根据需要允许起泡。 在另一种形式中，气囊包括主要为非弹性或相当刚性弹性的壁材料的单个腔室，但具有球囊壁具有弹性或比主气囊壁基本上更有弹性的“窗口”或区域，从而使 气球直到某一点形成基本上规则的气球形状（其可以近似为球形），并且增加进一步的压力将使弹性区域起泡以增加轴和敏感组织之间的距离， 气球。
-
公开(公告)号：US20120053390A1
公开(公告)日：2012-03-01
申请号：US13291854
申请日：2011-11-08
申请人： Steve Axelrod , Robert R. Burnside , Paul A. Lovoi
发明人： Steve Axelrod , Robert R. Burnside , Paul A. Lovoi
IPC分类号： A61M36/12
CPC分类号： A61B19/40 , A61B90/04 , A61B2090/0436 , A61N5/1001 , A61N2005/1094
摘要： Attenuating masks for selective attenuation of radiation, particularly from an x-ray source in brachytherapy, employ materials having atomic number in a specific range, so as to attenuate radiation dose intensity generally proportionally through a range of distance from the source. Some preferred attenuation materials are silver and molybdenum. A set of small masks can be provided for a particular design of catheter that holds a radiation source, each mask having a size and shape to define a different solid angle of masking, so that in a brachytherapy procedure, sensitive tissue such as bone or skin can be protected by proper selection of and positioning of the attenuating mask, to reduce the dose intensity to that tissue.
摘要翻译： 用于选择性衰减辐射的衰减掩模，特别是来自近距离放射治疗中的X射线源，使用具有特定范围内的原子序数的材料，以便通过成比例的方式衰减辐射剂量强度，从而远离源的距离。 一些优选的衰减材料是银和钼。 可以为保持辐射源的导管的特定设计提供一组小的掩模，每个掩模具有尺寸和形状以限定不同的立体角度掩蔽，使得在近程放射治疗程序中，诸如骨骼或皮肤的敏感组织 可以通过适当选择和定位衰减掩模来保护，以减少对该组织的剂量强度。
-
公开(公告)号：US08062203B2
公开(公告)日：2011-11-22
申请号：US12072620
申请日：2008-02-26
申请人： Steve Axelrod , Robert R. Burnside , Paul A. Lovoi
发明人： Steve Axelrod , Robert R. Burnside , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61B19/40 , A61B90/04 , A61B2090/0436 , A61N5/1001 , A61N2005/1094
摘要： Attenuating masks for selective attenuation of radiation, particularly from an x-ray source in brachytherapy, employ materials having atomic number in a specific range, so as to attenuate radiation dose intensity generally proportionally through a range of distance from the source. Some preferred attenuation materials are silver and molybdenum. A set of small masks can be provided for a particular design of catheter that holds a radiation source, each mask having a size and shape to define a different solid angle of masking, so that in a brachytherapy procedure, sensitive tissue such as bone or skin can be protected by proper selection of and positioning of the attenuating mask, to reduce the dose intensity to that tissue.
摘要翻译： 用于选择性衰减辐射的衰减掩模，特别是来自近距离放射治疗中的X射线源，使用具有特定范围内的原子序数的材料，以便通过成比例的方式衰减辐射剂量强度，从而远离源的距离。 一些优选的衰减材料是银和钼。 可以为保持辐射源的导管的特定设计提供一组小的掩模，每个掩模具有尺寸和形状以限定不同的立体角度掩蔽，使得在近程放射治疗程序中，诸如骨骼或皮肤的敏感组织 可以通过适当选择和定位衰减掩模来保护，以减少对该组织的剂量强度。
-
-
-
-
-
-
-
-
-
搜索结果
86 条记录 (耗时 0.031 秒)
