公开(公告)号：US20120053390A1

公开(公告)日：2012-03-01

申请号：US13291854

申请日：2011-11-08

申请人： Steve Axelrod ,  Robert R. Burnside ,  Paul A. Lovoi

发明人： Steve Axelrod ,  Robert R. Burnside ,  Paul A. Lovoi

IPC分类号： A61M36/12

CPC分类号： A61B19/40 ,  A61B90/04 ,  A61B2090/0436 ,  A61N5/1001 ,  A61N2005/1094

摘要： Attenuating masks for selective attenuation of radiation, particularly from an x-ray source in brachytherapy, employ materials having atomic number in a specific range, so as to attenuate radiation dose intensity generally proportionally through a range of distance from the source. Some preferred attenuation materials are silver and molybdenum. A set of small masks can be provided for a particular design of catheter that holds a radiation source, each mask having a size and shape to define a different solid angle of masking, so that in a brachytherapy procedure, sensitive tissue such as bone or skin can be protected by proper selection of and positioning of the attenuating mask, to reduce the dose intensity to that tissue.

摘要翻译： 用于选择性衰减辐射的衰减掩模，特别是来自近距离放射治疗中的X射线源，使用具有特定范围内的原子序数的材料，以便通过成比例的方式衰减辐射剂量强度，从而远离源的距离。 一些优选的衰减材料是银和钼。 可以为保持辐射源的导管的特定设计提供一组小的掩模，每个掩模具有尺寸和形状以限定不同的立体角度掩蔽，使得在近程放射治疗程序中，诸如骨骼或皮肤的敏感组织 可以通过适当选择和定位衰减掩模来保护，以减少对该组织的剂量强度。

公开(公告)号：US08062203B2

公开(公告)日：2011-11-22

申请号：US12072620

申请日：2008-02-26

申请人： Steve Axelrod ,  Robert R. Burnside ,  Paul A. Lovoi

发明人： Steve Axelrod ,  Robert R. Burnside ,  Paul A. Lovoi

IPC分类号： A61N5/00

CPC分类号： A61B19/40 ,  A61B90/04 ,  A61B2090/0436 ,  A61N5/1001 ,  A61N2005/1094

摘要： Attenuating masks for selective attenuation of radiation, particularly from an x-ray source in brachytherapy, employ materials having atomic number in a specific range, so as to attenuate radiation dose intensity generally proportionally through a range of distance from the source. Some preferred attenuation materials are silver and molybdenum. A set of small masks can be provided for a particular design of catheter that holds a radiation source, each mask having a size and shape to define a different solid angle of masking, so that in a brachytherapy procedure, sensitive tissue such as bone or skin can be protected by proper selection of and positioning of the attenuating mask, to reduce the dose intensity to that tissue.

摘要翻译： 用于选择性衰减辐射的衰减掩模，特别是来自近距离放射治疗中的X射线源，使用具有特定范围内的原子序数的材料，以便通过成比例的方式衰减辐射剂量强度，从而远离源的距离。 一些优选的衰减材料是银和钼。 可以为保持辐射源的导管的特定设计提供一组小的掩模，每个掩模具有尺寸和形状以限定不同的立体角度掩蔽，使得在近程放射治疗程序中，诸如骨骼或皮肤的敏感组织 可以通过适当选择和定位衰减掩模来保护，以减少对该组织的剂量强度。

公开(公告)号：US20090216062A1

公开(公告)日：2009-08-27

申请号：US12072620

申请日：2008-02-26

申请人： Steve Axelrod ,  Robert R. Burnside ,  Paul A. Lovoi

发明人： Steve Axelrod ,  Robert R. Burnside ,  Paul A. Lovoi

IPC分类号： A61M36/08

CPC分类号： A61B19/40 ,  A61B90/04 ,  A61B2090/0436 ,  A61N5/1001 ,  A61N2005/1094

摘要： Attenuating masks for selective attenuation of radiation, particularly from an x-ray source in brachytherapy, employ materials having atomic number in a specific range, so as to attenuate radiation dose intensity generally proportionally through a range of distance from the source. Some preferred attenuation materials are silver and molybdenum. A set of small masks can be provided for a particular design of catheter that holds a radiation source, each mask having a size and shape to define a different solid angle of masking, so that in a brachytherapy procedure, sensitive tissue such as bone or skin can be protected by proper selection of and positioning of the attenuating mask, to reduce the dose intensity to that tissue.

摘要翻译： 用于选择性衰减辐射的衰减掩模，特别是来自近距离放射治疗中的X射线源，使用具有特定范围内的原子序数的材料，以便通过成比例的方式衰减辐射剂量强度，从而远离源的距离。 一些优选的衰减材料是银和钼。 可以为保持辐射源的导管的特定设计提供一组小的掩模，每个掩模具有尺寸和形状以限定不同的立体角度掩蔽，使得在近程放射治疗程序中，诸如骨骼或皮肤的敏感组织 可以通过适当选择和定位衰减掩模来保护，以减少对该组织的剂量强度。

公开(公告)号：US09055972B2

公开(公告)日：2015-06-16

申请号：US13291854

申请日：2011-11-08

申请人： Steve Axelrod ,  Robert R. Burnside ,  Paul A. Lovoi

发明人： Steve Axelrod ,  Robert R. Burnside ,  Paul A. Lovoi

IPC分类号： A61N5/10 ,  A61B19/00

CPC分类号： A61B19/40 ,  A61B90/04 ,  A61B2090/0436 ,  A61N5/1001 ,  A61N2005/1094

摘要： Attenuating masks for selective attenuation of radiation, particularly from an x-ray source in brachytherapy, employ materials having atomic number in a specific range, so as to attenuate radiation dose intensity generally proportionally through a range of distance from the source. Some preferred attenuation materials are silver and molybdenum. A set of small masks can be provided for a particular design of catheter that holds a radiation source, each mask having a size and shape to define a different solid angle of masking, so that in a brachytherapy procedure, sensitive tissue such as bone or skin can be protected by proper selection of and positioning of the attenuating mask, to reduce the dose intensity to that tissue.

摘要翻译： 用于选择性衰减辐射的衰减掩模，特别是来自近距离放射治疗中的X射线源，使用具有特定范围内的原子序数的材料，以便通过成比例的方式衰减辐射剂量强度，从而远离源的距离。 一些优选的衰减材料是银和钼。 可以为保持辐射源的导管的特定设计提供一组小的掩模，每个掩模具有尺寸和形状以限定不同的立体角度掩蔽，使得在近程放射治疗程序中，诸如骨骼或皮肤的敏感组织 可以通过适当选择和定位衰减掩模来保护，以减少对该组织的剂量强度。

公开(公告)号：US20100127181A1

公开(公告)日：2010-05-27

申请号：US12321593

申请日：2009-01-21

申请人： Paul A. Lovoi ,  Steve Axelrod

发明人： Paul A. Lovoi ,  Steve Axelrod

IPC分类号： G01T1/02

CPC分类号： G01T1/00 ,  G01T1/026

摘要： A radiation sensor array is carried on a flexible sheet of film, for placement on the skin of a patient adjacent to a brachytherapy location beneath the skin. With the array approximately centered on a position where radiation source to skin distance is estimated to be minimum, the array of sensors is used to monitor radiation dose received at the skin. With a controller connected to the array and preferably also to the radiation source in the applicator, the radiation dose received at all skin points of interest can be monitored, a point of maximum dose and a projected approach to limit dose can be calculated, and in response the system can warn the operator or control a brachytherapy procedure so as to discontinue radiation or control the radiation level or source position in real time. The system can also include percutaneous sensors.

摘要翻译： 辐射传感器阵列承载在柔性薄膜片上，用于放置在与皮肤附近的近距离放射治疗位置相邻的患者的皮肤上。 以阵列为中心，辐射源至皮肤距离估计为最小的位置，传感器阵列用于监测皮肤接收的辐射剂量。 通过将控制器连接到阵列并且优选地也连接到施用器中的辐射源，可以监测在所有皮肤感兴趣点处接收的辐射剂量，可以计算最大剂量点和限制剂量的预计接近点，并且在 响应系统可以警告操作者或控制近距离放射治疗程序，以便实时中止辐射或控制辐射水平或源位置。 该系统还可以包括经皮传感器。

公开(公告)号：US20100074407A1

公开(公告)日：2010-03-25

申请号：US12284289

申请日：2008-09-19

申请人： Steve Axelrod ,  Thomas W. Rusch ,  Paul A. Lovoi ,  Anuradha Walawalkar ,  Sara Z. Yao

发明人： Steve Axelrod ,  Thomas W. Rusch ,  Paul A. Lovoi ,  Anuradha Walawalkar ,  Sara Z. Yao

IPC分类号： A61N5/10

CPC分类号： A61N5/10 ,  A61N5/1001 ,  A61N2005/1091 ,  A61N2005/1094 ,  A61N2005/1095

摘要： An apparatus and method for treatment of lesions or imperfections in or near exposed anatomic surfaces using low-level ionizing radiation includes a substantially transparent applicator to administer radiation from an energy source to a surface area with the lesion. The applicator is positioned over the lesion to be treated, a treatment plan is created to achieve the desired therapeutic effect to the lesion, and execution of the treatment plan is executed by the energy source. Verification of the treatment to plan and safety methods are disclosed.

摘要翻译： 用于使用低级电离辐射治疗暴露的解剖表面内或附近的损伤或缺陷的装置和方法包括基本上透明的施用器，以将能量源的辐射施加到具有损伤的表面区域。 施用器位于要治疗的病变上，创建治疗计划以实现对病变的期望的治疗效果，并且由能量源执行治疗计划的执行。 公开了对计划和安全方法的处理的验证。

公开(公告)号：US20090030258A1

公开(公告)日：2009-01-29

申请号：US11881835

申请日：2007-07-28

申请人： Steve Axelrod ,  James E. Jervis ,  Paul A. Lovoi

发明人： Steve Axelrod ,  James E. Jervis ,  Paul A. Lovoi

IPC分类号： A61M36/06

CPC分类号： A61M25/1011 ,  A61B2017/22069 ,  A61M25/1002 ,  A61M2025/1061 ,  A61N5/1015

摘要： A balloon brachytherapy applicator has either a single or double chambers, with the capability of “blistering” outwardly at a specified area on one side of the balloon. This is useful to move sensitive tissue, such as skin or bone, farther away from a radiation source within a source guide inside the balloon. In one case a secondary balloon or secondary compartment is formed on the primary balloon, and is separately inflatable so as to allow blistering as desired when needed. In another form the balloon comprises a single chamber, primarily of inelastic or fairly rigidly elastic wall material, but with a “window” or area in which the balloon wall is elastic, or substantially more elastic than the main balloon wall, so that inflation of the balloon up to a certain point forms a substantially regular balloon shape (which may be approximately spherical), and the addition of further pressure will blister out the elastic area to increase the distance between the shaft and the sensitive tissue in a desired orientation of the balloon.

摘要翻译： 气球近距离放射治疗器具有单室或双室，在气球一侧的指定区域处具有“起泡”的能力。 这对于将敏感组织（例如皮肤或骨骼）移动离气囊内的源引导件内的辐射源更远是有用的。 在一种情况下，次级球囊或次级隔室形成在主气囊上，并且可分开地充气，以便在需要时根据需要允许起泡。 在另一种形式中，气囊包括主要为非弹性或相当刚性弹性的壁材料的单个腔室，但具有球囊壁具有弹性或比主气囊壁基本上更有弹性的“窗口”或区域，从而使 气球直到某一点形成基本上规则的气球形状（其可以近似为球形），并且增加进一步的压力将使弹性区域起泡以增加轴和敏感组织之间的距离， 气球。

公开(公告)号：US08354658B1

公开(公告)日：2013-01-15

申请号：US12800083

申请日：2010-05-06

申请人： Peter C. Smith ,  Steve Axelrod ,  Paul A. Lovoi

发明人： Peter C. Smith ,  Steve Axelrod ,  Paul A. Lovoi

IPC分类号： G21F3/02

CPC分类号： G21F1/125 ,  G21F3/02 ,  G21Y2002/201 ,  G21Y2002/501 ,  G21Y2004/30

摘要： A flexible, lightweight radiation absorbing sheet or shield includes heavy metal particles in one layer and mid-atomic number particles in another layer, the layer that will be adjacent to the patient. The shield is particularly intended for protection of the wearer and others from radiation emanating from a therapeutic source positioned within the patient's body. With the disclosed multi-layer shield construction, backscattered radiation off the heavy metal particle layer, affecting the patient's adjacent tissue, is minimized.

摘要翻译： 柔性，轻便的辐射吸收片或屏蔽层包括一层中的重金属颗粒和另一层中的原子序数颗粒，该层将与患者相邻。 护罩特别用于保护佩戴者和其他人免受来自位于患者体内的治疗源的辐射。 利用所公开的多层屏蔽结构，使重金属颗粒层的背散射辐射，影响患者的相邻组织，被最小化。

公开(公告)号：US07771340B2

公开(公告)日：2010-08-10

申请号：US11881835

申请日：2007-07-28

申请人： Steve Axelrod ,  James E. Jervis ,  Paul A. Lovoi

发明人： Steve Axelrod ,  James E. Jervis ,  Paul A. Lovoi

IPC分类号： A61N5/00

CPC分类号： A61M25/1011 ,  A61B2017/22069 ,  A61M25/1002 ,  A61M2025/1061 ,  A61N5/1015

摘要： A balloon brachytherapy applicator has either a single or double chambers, with the capability of “blistering” outwardly at a specified area on one side of the balloon. This is useful to move sensitive tissue farther away from a radiation source within a source guide inside the balloon. In one case a secondary compartment is formed on the primary balloon, and is separately inflatable so as to allow blistering as desired when needed. In another form the balloon comprises a single chamber but with a “window” or area in which the balloon wall is elastic, or substantially more elastic than the main balloon wall, so that inflation of the balloon up to a certain point forms a substantially regular balloon shape, and the addition of further pressure will blister out the elastic area to increase the distance between the shaft and the sensitive tissue in a desired orientation of the balloon.

摘要翻译： 气球近距离放射治疗器具有单室或双室，在气球一侧的指定区域处具有“起泡”的能力。 这对于使敏感组织更远离辐射源在气囊内的源引导件内是有用的。 在一种情况下，次级隔室形成在主气囊上，并且可分开地充气，以便在需要时允许起泡。 在另一种形式中，球囊包括单个腔室，但是具有“窗口”或其中球囊壁具有弹性的区域或者比主气囊壁基本上更有弹性的区域，使得球囊到达某一点的膨胀形成基本上规则的 气球形状，并且增加进一步的压力将使弹性区域膨胀，从而在气球的期望取向上增加轴与敏感组织之间的距离。

公开(公告)号：US20080214887A1

公开(公告)日：2008-09-04

申请号：US12082492

申请日：2008-04-10

申请人： Joseph A. Heanue ,  Paul A. Lovoi ,  Steve Axelrod ,  James E. Jervis

发明人： Joseph A. Heanue ,  Paul A. Lovoi ,  Steve Axelrod ,  James E. Jervis

IPC分类号： A61M36/04

CPC分类号： A61N5/1014 ,  A61M2025/1063 ,  A61N5/1015 ,  A61N5/1048 ,  A61N2005/1018

摘要： A brachytherapy applicator and method of use involve source guides that assume a desired curving, non-linear configuration. A flexible source catheter follows the shape of the source guides when inserted therein. Radiation dose received in various tissue areas can be better controlled using the invention, and the ratio of cavity surface dose to prescription depth dose can be lowered. With sequential manipulation of the source via movement of the catheter, the applicator can deliver radiotherapy to a treatment plan with local variation to prevent overdose, through either stepped or continuous movement of the source. Source guides can be fixed in position and arranged in bowed configuration around a generally central balloon axis, either attached to the balloon wall or not, and the series of off-center guides can be used to shape the dose delivered.

摘要翻译： 近距离放射疗法施加器和使用方法包括采用期望的弯曲非线性构造的源引导件。 当插入其中时，柔性源导管遵循源极引导件的形状。 可以使用本发明更好地控制在各组织区域中接收的辐射剂量，并且可以降低腔表面剂量与处方深度剂量的比例。 通过导管的运动对源进行顺序操作，施用器可以将放射治疗递送到具有局部变化的治疗计划，以通过源的逐步或连续运动来防止过量。 源引导件可以被固定在适当位置并且围绕一般中心的气球轴线以弓形的形式布置，或者附接到球囊壁，并且可以使用一系列偏心导向器来调整所输送的剂量。