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公开(公告)号：US07439239B2
公开(公告)日：2008-10-21
申请号：US11313635
申请日：2005-12-21
申请人： Steve Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： Steve Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： C07D413/08 , C07D413/14 , A61K31/538
CPC分类号： C07D451/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: wherein A, G, Y, R3-R5 are defined herein.
摘要翻译： 公开了用于治疗各种疾病和病症（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，G，Y，R 3〜R 5在本文中定义。
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公开(公告)号：US07652005B2
公开(公告)日：2010-01-26
申请号：US12248150
申请日：2008-10-09
申请人： Steve Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： Steve Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： C07D471/08 , A61K31/5415 , A61K31/538
CPC分类号： C07D451/04
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译： 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环类阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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公开(公告)号：US20090042871A1
公开(公告)日：2009-02-12
申请号：US12248150
申请日：2008-10-09
申请人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： A61K31/5415 , C07D471/08 , A61P25/00 , A61K31/538
CPC分类号： C07D451/04
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译： 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环类阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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4.发明授权Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators 失效哌嗪基 - 吩恶嗪和吩噻嗪衍生物作为δ-阿片样物质调节剂公开(公告)号：US07432257B2
公开(公告)日：2008-10-07
申请号：US11326084
申请日：2006-01-05
申请人： Steve J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： Steve J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： A61K31/535 , A61K31/54 , C07D265/38 , C07D417/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译： 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环类阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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5.发明授权公开(公告)号：US07589104B2
公开(公告)日：2009-09-15
申请号：US11313704
申请日：2005-12-21
申请人： John R. Carson , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： John R. Carson , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： C07D405/04 , A61K31/46
CPC分类号： C07D451/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: wherein A, G, Y, R3, R4, and R5 are defined herein.
摘要翻译： 公开了用于治疗各种疾病和病症（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，G，Y，R 3，R 4和R 5在本文中定义。
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公开(公告)号：US20100093709A1
公开(公告)日：2010-04-15
申请号：US12622548
申请日：2009-11-20
申请人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： A61K31/5415 , C07D413/02 , C07D413/14 , C07D417/14 , A61K31/538
CPC分类号： C07D451/04
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译： 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环δ-阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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公开(公告)号：US20080318937A1
公开(公告)日：2008-12-25
申请号：US12196865
申请日：2008-08-22
申请人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： A61K31/5415 , C07D417/14 , C07D413/14 , A61K31/538 , A61P25/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译： 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环类阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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公开(公告)号：US20080306111A1
公开(公告)日：2008-12-11
申请号：US12187680
申请日：2008-08-07
申请人： John R. Carson , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
发明人： John R. Carson , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
IPC分类号： A61K31/4545 , C07D405/14 , A61K31/4535 , C07D409/04 , A61K31/453
CPC分类号： C07D405/14 , C07D405/04 , C07D409/14 , C07D413/14
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译： 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环类阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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公开(公告)号：US20060135763A1
公开(公告)日：2006-06-22
申请号：US11313635
申请日：2005-12-21
申请人： Steve Coats , Scott Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
发明人： Steve Coats , Scott Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
IPC分类号： C07D417/04 , C07D413/14
CPC分类号： C07D451/04
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
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公开(公告)号：US20060135524A1
公开(公告)日：2006-06-22
申请号：US11313704
申请日：2005-12-21
申请人： John Carson , Scott Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
发明人： John Carson , Scott Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
IPC分类号： A61K31/506 , A61K31/497 , A61K31/501 , A61K31/4709 , A61K31/445 , C07D403/02
CPC分类号： C07D451/02
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译： 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环类阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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