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1.发明授权公开(公告)号：US07706874B2
公开(公告)日：2010-04-27
申请号：US11191340
申请日：2005-07-28
IPC分类号： A61N1/00
CPC分类号： A61N1/36053
摘要： A method, system, and an apparatus for stimulating a cranial nerve of a patient to treat a disorder, such as a metabolic or an endocrine disorder associated with the thyroid gland with an implantable medical device are provided. The method comprises coupling an electrode to the cranial nerve selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve. The method further includes generating an electrical signal to treat a disorder associated with the thyroid gland. The electrical signal may be applied to the cranial nerve using the electrode to provide electrical nerve stimulation therapy to the patient. For treating a patient with a metabolic or an endocrine disorder associated with the thyroid gland, a neurostimulator may be adapted to apply an electrical stimulus to the vagus nerve and/or a branch of the vagus nerve associated with the thyroid gland. By balancing hormonal imbalance, the neurostimulator may provide electrical nerve stimulation therapy to the patient, thereby treating a target metabolic or an endocrine disorder associated with the thyroid gland.
摘要翻译： 提供了一种用于通过可植入医疗装置刺激患者的颅神经以治疗诸如与甲状腺相关的代谢或内分泌紊乱的病症的方法，系统和装置。 该方法包括将电极连接到选自迷走神经，三叉神经和咽舌神经的颅神经中。 该方法还包括产生电信号以治疗与甲状腺相关的病症。 可以使用电极将电信号施加到颅神经，以向患者提供电神经刺激治疗。 为了治疗患有与甲状腺相关的代谢或内分泌紊乱的患者，神经刺激器可适用于向迷走神经和/或与甲状腺相关的迷走神经的分支施加电刺激。 通过平衡激素不平衡，神经刺激器可以向患者提供电神经刺激疗法，从而治疗与甲状腺相关的靶代谢或内分泌紊乱。
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公开(公告)号：US20110178569A1
公开(公告)日：2011-07-21
申请号：US13075662
申请日：2011-03-30
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： Systems and methods to treat a pulmonary disorder are provided. A particular method includes positioning an electrode in a patient's body at a location proximate a branch of a vagus nerve. The branch of the vagus nerve includes at least one of a bronchial branch of the vagus nerve and a pulmonary plexus. The method also includes activating the electrode such that energy is delivered from the electrode to the branch of the vagus nerve so as to block intrinsic neural activity in the branch of the vagus nerve to treat the pulmonary disorder.
摘要翻译： 提供了治疗肺部疾病的系统和方法。 一种特定的方法包括将电极定位在靠近迷走神经分支的位置处的患者体内。 迷走神经的分支包括迷走神经的支气管分支和肺丛中的至少一个。 该方法还包括激活电极，使得能量从电极传递到迷走神经的分支，以阻止迷走神经的分支中的内在神经活动以治疗肺部疾病。
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公开(公告)号：US07974697B2
公开(公告)日：2011-07-05
申请号：US11340337
申请日：2006-01-26
IPC分类号： A61N1/36
CPC分类号： A61N1/08 , A61N1/36071
摘要： A method, system, and apparatus are provided for performing an adaptive stimulation process using medical imaging feedback data for affecting an operation of an implantable medical device. The first stimulation signal is applied to a neural structure for modulation of a target portion of the patient's brain associated with a disorder. Medical imaging data is acquired that is indicative of whether the target portion of the brain is modulated as a result of the first stimulation signal. The first signal characteristic is modified to generate a second stimulation signal in response to a determination that said target portion of the brain is not modulated as a result of said first stimulation signal. The first and second stimulation signals may be used to navigate an effect of the first and second stimulation signals until a targeted portion of the human body is stimulated according to a predetermined threshold.
摘要翻译： 提供了一种方法，系统和装置，用于使用用于影响可植入医疗装置的操作的医学成像反馈数据来执行自适应刺激过程。 将第一刺激信号应用于神经结构，用于调节与病症相关的患者脑部的目标部分。 获取指示大脑的目标部分是否作为第一刺激信号的结果被调制的医学成像数据。 响应于作为所述第一刺激信号的结果，大脑的所述目标部分未被调制的确定，第一信号特征被修改以产生第二刺激信号。 可以使用第一和第二刺激信号来导航第一和第二刺激信号的效果，直到根据预定阈值刺激人体的目标部分。
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公开(公告)号：US07856273B2
公开(公告)日：2010-12-21
申请号：US11191846
申请日：2005-07-28
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61N1/36007
摘要： A method and apparatus for stimulating a portion of a vagus nerve of a patient to treat a gastrointestinal disorder is provided. At least one electrode is coupled to at least one portion of a vagus nerve of the patient. The portion of the a vagus nerve may include an esophageal plexus, a myenteric plexus of aurbach, a submucous plexus of the meissner, a principal nerve of the lesser curvature of the stomach, and a gastric branch of said vagus nerve. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the gastrointestinal disorder.
摘要翻译： 提供了一种用于刺激患者的迷走神经的一部分以治疗胃肠道疾病的方法和装置。 至少一个电极耦合到患者的迷走神经的至少一部分。 迷走神经的一部分可以包括食道丛，aurbach的肌间神经丛，meissner的粘膜下神经丛，胃的较小曲率的主要神经和所述迷走神经的胃分支。 使用电极将电信号施加到迷走神经的部分以治疗胃肠道疾病。
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公开(公告)号：US08660647B2
公开(公告)日：2014-02-25
申请号：US11191896
申请日：2005-07-28
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： A method for stimulating a portion of a vagus nerve of a patient to treat a pulmonary disorder is provided. At least one electrode is coupled to at least one portion of a left vagus nerve and/or a right vagus nerve of the patient. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the pulmonary disorder. The electrical signal may perform a blocking of an intrinsic neural activity on said at least one portion of the left vagus nerve and said right vagus nerve.
摘要翻译： 提供了一种用于刺激患者的迷走神经的一部分以治疗肺部疾病的方法。 至少一个电极耦合到患者的左迷走神经和/或右侧迷走神经的至少一部分。 使用电极将电信号施加到迷走神经的部分以治疗肺部疾病。 电信号可以在左迷走神经和右迷走神经的所述至少一部分上执行内在神经活动的阻断。
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公开(公告)号：US20080183226A1
公开(公告)日：2008-07-31
申请号：US11698226
申请日：2007-01-25
IPC分类号： A61N1/36
CPC分类号： A61N1/36114
摘要： A method of treating a patient undergoing pharmacotherapy with a selected drug for treatment of a medical disorder is provided which comprises: (a) administering the selected drug to said patient at a first time point, to treat the medical disorder; and (b) applying an electrical signal to a vagus nerve of the patient at a second time point, wherein the signal is selected so as to modulate at least one pharmacologic and/or pharmacokinetic property of the selected drug in the body of the patient. The vagus nerve stimulation (VNS) modulated drug therapy may be performed secondarily to, and in conjunction with, application of a primary VNS therapy to the patient for treatment of the same or a different medical disorder, to enhance treatment of the patient.
摘要翻译： 提供了一种用选择的用于治疗医学病症的药物进行药物治疗的患者的方法，其包括：（a）在第一时间点向所述患者施用所选择的药物，以治疗所述医学病症; 和（b）在第二时间点向患者的迷走神经施加电信号，其中所述信号被选择为调节所选药物在患者体内的至少一种药理学和/或药代动力学性质。 迷走神经刺激（VNS）调节药物治疗可以次要地进行，并且与主要VNS治疗一起应用于患者以治疗相同或不同的医学病症，以增强患者的治疗。
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7.发明授权公开(公告)号：US07657310B2
公开(公告)日：2010-02-02
申请号：US11340309
申请日：2006-01-26
申请人： William R. Buras
发明人： William R. Buras
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61N1/36007 , A61N1/3615 , A61N1/36167
摘要： I disclose a method of treating a reproductive endocrine disorder in a patient, including coupling at least one electrode to at least one portion of a cranial nerve of the patient; and applying an electrical signal to said cranial nerve using said electrode to treat said reproductive endocrine disorder. Among the reproductive endocrine disorders which may be treated by the method are gonadal dysgenesis, hypogonadism, hypergonadism, delayed puberty, amenorrhea, infertility, premature menopause, and polycystic ovarian disease.
摘要翻译： 我公开了一种治疗患者生殖内分泌紊乱的方法，包括将至少一个电极耦合到患者的颅神经的至少一部分; 以及使用所述电极向所述颅神经施加电信号以治疗所述生殖内分泌紊乱。 可以通过该方法治疗的生殖性内分泌障碍是性腺发育不良，性腺机能减退，超神经痛，青春期延迟，闭经，不孕，早产绝经和多囊卵巢疾病。
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公开(公告)号：US07706875B2
公开(公告)日：2010-04-27
申请号：US11698226
申请日：2007-01-25
IPC分类号： A61N1/00
CPC分类号： A61N1/36114
摘要： A method of treating a patient undergoing pharmacotherapy with a selected drug for treatment of a medical disorder is provided which comprises: (a) administering the selected drug to said patient at a first time point, to treat the medical disorder; and (b) applying an electrical signal to a vagus nerve of the patient at a second time point, wherein the signal is selected so as to modulate at least one pharmacologic and/or pharmacokinetic property of the selected drug in the body of the patient. The vagus nerve stimulation (VNS) modulated drug therapy may be performed secondarily to, and in conjunction with, application of a primary VNS therapy to the patient for treatment of the same or a different medical disorder, to enhance treatment of the patient.
摘要翻译： 提供了一种用选择的用于治疗医学病症的药物进行药物治疗的患者的方法，其包括：（a）在第一时间点向所述患者施用所选择的药物，以治疗所述医学病症; 和（b）在第二时间点向患者的迷走神经施加电信号，其中所述信号被选择为调节所选药物在患者体内的至少一种药理学和/或药代动力学性质。 迷走神经刺激（VNS）调节药物治疗可以次要地进行，并且与主要VNS治疗一起应用于患者以治疗相同或不同的医学病症，以增强患者的治疗。
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