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1.发明授权公开(公告)号：US07706874B2
公开(公告)日：2010-04-27
申请号：US11191340
申请日：2005-07-28
IPC分类号： A61N1/00
CPC分类号： A61N1/36053
摘要： A method, system, and an apparatus for stimulating a cranial nerve of a patient to treat a disorder, such as a metabolic or an endocrine disorder associated with the thyroid gland with an implantable medical device are provided. The method comprises coupling an electrode to the cranial nerve selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve. The method further includes generating an electrical signal to treat a disorder associated with the thyroid gland. The electrical signal may be applied to the cranial nerve using the electrode to provide electrical nerve stimulation therapy to the patient. For treating a patient with a metabolic or an endocrine disorder associated with the thyroid gland, a neurostimulator may be adapted to apply an electrical stimulus to the vagus nerve and/or a branch of the vagus nerve associated with the thyroid gland. By balancing hormonal imbalance, the neurostimulator may provide electrical nerve stimulation therapy to the patient, thereby treating a target metabolic or an endocrine disorder associated with the thyroid gland.
摘要翻译： 提供了一种用于通过可植入医疗装置刺激患者的颅神经以治疗诸如与甲状腺相关的代谢或内分泌紊乱的病症的方法，系统和装置。 该方法包括将电极连接到选自迷走神经，三叉神经和咽舌神经的颅神经中。 该方法还包括产生电信号以治疗与甲状腺相关的病症。 可以使用电极将电信号施加到颅神经，以向患者提供电神经刺激治疗。 为了治疗患有与甲状腺相关的代谢或内分泌紊乱的患者，神经刺激器可适用于向迷走神经和/或与甲状腺相关的迷走神经的分支施加电刺激。 通过平衡激素不平衡，神经刺激器可以向患者提供电神经刺激疗法，从而治疗与甲状腺相关的靶代谢或内分泌紊乱。
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公开(公告)号：US08660647B2
公开(公告)日：2014-02-25
申请号：US11191896
申请日：2005-07-28
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： A method for stimulating a portion of a vagus nerve of a patient to treat a pulmonary disorder is provided. At least one electrode is coupled to at least one portion of a left vagus nerve and/or a right vagus nerve of the patient. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the pulmonary disorder. The electrical signal may perform a blocking of an intrinsic neural activity on said at least one portion of the left vagus nerve and said right vagus nerve.
摘要翻译： 提供了一种用于刺激患者的迷走神经的一部分以治疗肺部疾病的方法。 至少一个电极耦合到患者的左迷走神经和/或右侧迷走神经的至少一部分。 使用电极将电信号施加到迷走神经的部分以治疗肺部疾病。 电信号可以在左迷走神经和右迷走神经的所述至少一部分上执行内在神经活动的阻断。
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公开(公告)号：US20110178569A1
公开(公告)日：2011-07-21
申请号：US13075662
申请日：2011-03-30
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： Systems and methods to treat a pulmonary disorder are provided. A particular method includes positioning an electrode in a patient's body at a location proximate a branch of a vagus nerve. The branch of the vagus nerve includes at least one of a bronchial branch of the vagus nerve and a pulmonary plexus. The method also includes activating the electrode such that energy is delivered from the electrode to the branch of the vagus nerve so as to block intrinsic neural activity in the branch of the vagus nerve to treat the pulmonary disorder.
摘要翻译： 提供了治疗肺部疾病的系统和方法。 一种特定的方法包括将电极定位在靠近迷走神经分支的位置处的患者体内。 迷走神经的分支包括迷走神经的支气管分支和肺丛中的至少一个。 该方法还包括激活电极，使得能量从电极传递到迷走神经的分支，以阻止迷走神经的分支中的内在神经活动以治疗肺部疾病。
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公开(公告)号：US07856273B2
公开(公告)日：2010-12-21
申请号：US11191846
申请日：2005-07-28
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61N1/36007
摘要： A method and apparatus for stimulating a portion of a vagus nerve of a patient to treat a gastrointestinal disorder is provided. At least one electrode is coupled to at least one portion of a vagus nerve of the patient. The portion of the a vagus nerve may include an esophageal plexus, a myenteric plexus of aurbach, a submucous plexus of the meissner, a principal nerve of the lesser curvature of the stomach, and a gastric branch of said vagus nerve. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the gastrointestinal disorder.
摘要翻译： 提供了一种用于刺激患者的迷走神经的一部分以治疗胃肠道疾病的方法和装置。 至少一个电极耦合到患者的迷走神经的至少一部分。 迷走神经的一部分可以包括食道丛，aurbach的肌间神经丛，meissner的粘膜下神经丛，胃的较小曲率的主要神经和所述迷走神经的胃分支。 使用电极将电信号施加到迷走神经的部分以治疗胃肠道疾病。
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公开(公告)号：US07840280B2
公开(公告)日：2010-11-23
申请号：US11191121
申请日：2005-07-27
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0456 , A61N1/36014 , A61N1/36053
摘要： Disclosed is a method of treating a patient having a vocal cord disorder, comprising coupling at least one electrode to at least one cranial nerve of the patient, wherein the cranial nerve is selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve, and applying an electrical signal to the cranial nerve using the electrode to treat the vocal cord disorder. The electrode may be coupled to a branch of the vagus nerve selected from the group consisting of a recurrent laryngeal nerve, the external branch of a superior laryngeal nerve, the internal branch of a superior laryngeal nerve, and a pharyngeal plexus. Also disclosed is a computer readable program storage device encoded with instructions that, when executed by a computer, perform the method, and a medical device and a vocal cord disorder treatment system that may be used in performance of the method.
摘要翻译： 公开了一种治疗具有声带病症的患者的方法，包括将至少一个电极耦合到患者的至少一个颅神经，其中所述颅神经选自迷走神经，三叉神经和 舌咽神经，并使用电极将电信号施加到颅神经以治疗声带紊乱。 电极可以耦合到迷走神经的分支，其选自复发性喉神经，上喉神经的外分支，上喉神经的内分支和咽神经丛。 还公开了一种计算机可读程序存储装置，其编码有当由计算机执行时执行该方法的指令，以及可用于执行该方法的医疗装置和声带紊乱处理系统。
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公开(公告)号：US07899540B2
公开(公告)日：2011-03-01
申请号：US11118980
申请日：2005-04-29
IPC分类号： A61N1/36
CPC分类号： A61F5/0026 , A61F5/005 , A61N1/36007
摘要： A method and apparatus for treatment of an eating disorder includes electrically stimulating the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. A device comprising a gastric band including stimulation electrodes may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. A programmable implantable stimulus generator may be operatively coupled to a nerve electrode. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译： 用于治疗进食障碍的方法和装置包括电刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导迷走神经的传入动作电位。 包括刺激电极的胃带的装置可以在植入后进行非侵入性调整，以对患者的胃肠道提供增加或减少的限制。 每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。 可编程植入式刺激发生器可以可操作地耦合到神经电极。 还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。
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公开(公告)号：US07835796B2
公开(公告)日：2010-11-16
申请号：US11118452
申请日：2005-04-29
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61F5/0003
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译： 用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入 迷走神经的动作电位。 该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。 每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。 可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。 可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。 还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。
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8.发明授权公开(公告)号：US07310557B2
公开(公告)日：2007-12-18
申请号：US11118861
申请日：2005-04-29
IPC分类号： A61N1/00
CPC分类号： A61F5/0026 , A61F5/005 , A61N1/36007 , A61N1/36082 , A61N1/36185 , A61N1/3686
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译： 用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入 迷走神经的动作电位。 该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。 每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。 可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。 可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。 还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。
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公开(公告)号：US07974697B2
公开(公告)日：2011-07-05
申请号：US11340337
申请日：2006-01-26
IPC分类号： A61N1/36
CPC分类号： A61N1/08 , A61N1/36071
摘要： A method, system, and apparatus are provided for performing an adaptive stimulation process using medical imaging feedback data for affecting an operation of an implantable medical device. The first stimulation signal is applied to a neural structure for modulation of a target portion of the patient's brain associated with a disorder. Medical imaging data is acquired that is indicative of whether the target portion of the brain is modulated as a result of the first stimulation signal. The first signal characteristic is modified to generate a second stimulation signal in response to a determination that said target portion of the brain is not modulated as a result of said first stimulation signal. The first and second stimulation signals may be used to navigate an effect of the first and second stimulation signals until a targeted portion of the human body is stimulated according to a predetermined threshold.
摘要翻译： 提供了一种方法，系统和装置，用于使用用于影响可植入医疗装置的操作的医学成像反馈数据来执行自适应刺激过程。 将第一刺激信号应用于神经结构，用于调节与病症相关的患者脑部的目标部分。 获取指示大脑的目标部分是否作为第一刺激信号的结果被调制的医学成像数据。 响应于作为所述第一刺激信号的结果，大脑的所述目标部分未被调制的确定，第一信号特征被修改以产生第二刺激信号。 可以使用第一和第二刺激信号来导航第一和第二刺激信号的效果，直到根据预定阈值刺激人体的目标部分。
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公开(公告)号：US07555344B2
公开(公告)日：2009-06-30
申请号：US11261182
申请日：2005-10-28
IPC分类号： A61N1/18
CPC分类号： A61M5/14276 , A61M2005/1726 , A61M2205/054 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N2/006
摘要： A method and device for treating epilepsy are disclosed which provide for electrical, chemical or magnetic stimulation of certain areas of the brain to modulate neuronal activity of areas associated with symptoms of epilepsy. Deep brain stimulation is combined with vagus nerve stimulation to enhance symptomatic relief of the disorder. Some embodiments also employ a sensing capability to optimize the therapeutic treatment regimen.
摘要翻译： 公开了用于治疗癫痫的方法和装置，其提供对脑的某些区域的电，化学或磁刺激以调节与癫痫症状相关的区域的神经元活动。 深部脑刺激与迷走神经刺激相结合，增强症状缓解症状。 一些实施例还采用感测能力来优化治疗治疗方案。
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