公开(公告)号：US06693077B1

公开(公告)日：2004-02-17

申请号：US09610651

申请日：2000-06-30

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian NI ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian NI ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K3818

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

公开(公告)号：US20100261194A1

公开(公告)日：2010-10-14

申请号：US12610128

申请日：2009-10-30

申请人： Guo-Liang YU ,  Reinhard EBNER ,  Jian NI

发明人： Guo-Liang YU ,  Reinhard EBNER ,  Jian NI

IPC分类号： G01N33/53 ,  C07K16/24

CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

摘要： The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.

摘要翻译： 本发明涉及一种Neutrokine-α抗体及其制备Neutrokine-α抗体的方法。 本发明还涉及用于鉴定抑制或增强中枢神经素α作用的化合物的筛选方法。 还提供了用于检测自身免疫疾病的诊断方法和使用中和碱α抗体治疗自身免疫疾病的治疗方法。

公开(公告)号：US20080292292A1

公开(公告)日：2008-11-27

申请号：US11950131

申请日：2007-12-04

申请人： Jian NI ,  Lijian WU ,  Wanbing JIN ,  Jianping YING ,  Shih-Ming Huang ,  Wen-Shi HUANG

发明人： Jian NI ,  Lijian WU ,  Wanbing JIN ,  Jianping YING ,  Shih-Ming Huang ,  Wen-Shi HUANG

IPC分类号： H02P7/285

CPC分类号： H02P6/15

摘要： A controller of a brushless DC electric machine having a rotor and at least a stator winding powered by a driving voltage is provided. The controller includes a position sensor, an advance angle control circuit, and a driving circuit. The position sensor is moved along a reverse rotating direction of the rotor by a prepositioned angle for outputting a position signal. The advance angle control circuit receives the position signal and a driving voltage reproduction signal reproduced from the driving voltage and outputs a commutation control signal lagging the position signal by a first delay time. The driving circuit receives the commutation control signal for outputting a driving signal for controlling a commutation of the brushless DC electric machine.

摘要翻译： 提供一种具有转子和至少由驱动电压驱动的定子绕组的无刷直流电机的控制器。 控制器包括位置传感器，提前角控制电路和驱动电路。 位置传感器沿转子的反向旋转方向移动一预定角度，用于输出位置信号。 提前角控制电路接收从驱动电压再现的位置信号和驱动电压再现信号，并输出滞后于位置信号第一延迟时间的换向控制信号。 驱动电路接收用于输出用于控制无刷直流电机的换向的驱动信号的换向控制信号。