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公开(公告)号：US06916786B2
公开(公告)日：2005-07-12
申请号：US10075446
申请日：2002-02-15
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/50 , C12N5/02 , C12N15/18 , A61K38/18 , C12N1/20 , C12N5/10
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , C07K14/50 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
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公开(公告)号：US6077692A
公开(公告)日：2000-06-20
申请号：US23082
申请日：1998-02-13
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/50 , C12N5/02 , C12N15/18 , A61K38/18 , C12N15/63
CPC分类号： C07H21/00 , C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
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公开(公告)号：US07232667B2
公开(公告)日：2007-06-19
申请号：US10733311
申请日：2003-12-12
申请人： Steven M. Ruben , Joachim R. Gruber , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Patrick J. Dillon , Reiner L. Gentz , Pablo Jimenez
发明人： Steven M. Ruben , Joachim R. Gruber , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Patrick J. Dillon , Reiner L. Gentz , Pablo Jimenez
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。
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公开(公告)号：US07208584B2
公开(公告)日：2007-04-24
申请号：US10123481
申请日：2002-04-17
CPC分类号： C07K14/50 , A01K67/027 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/026 , Y10S530/866
摘要： The present invention relates to a novel FGF-13 protein which is a member of the fibroblast growth factor (FGF) family. In particular, isolated nucleic acid molecules are provided encoding the human FGF-13 protein. FGF-13 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FGF-13 activity. Also provided are diagnostic methods for detecting FGF-13-related disorders and therapeutic methods for treating FGF-13-related disorders. Disclosed is a method of prolonging dopaminergic neuron survival.
摘要翻译： 本发明涉及作为成纤维细胞生长因子（FGF）家族成员的新型FGF-13蛋白。 特别地，提供编码人FGF-13蛋白的分离的核酸分子。 还提供FGF-13多肽，载体，宿主细胞以及用于制备其的重组方法。 本发明还涉及用于鉴定FGF-13活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测FGF-13相关病症的诊断方法和用于治疗FGF-13相关疾病的治疗方法。 公开了延长多巴胺能神经元存活的方法。
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公开(公告)号：US5728546A
公开(公告)日：1998-03-17
申请号：US462965
申请日：1995-06-05
摘要： Disclosed is a human Fibroblast growth factor-13 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage associated with stroke and due to neuronal disorders and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate anglogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译： 公开了人成纤维细胞生长因子-13多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止与中风相关的神经元损伤以及由于神经元紊乱并促进神经元生长，并且防止皮肤老化和脱发，以刺激 早期胚胎中的血管生成，中胚层诱导和肢体再生。 还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。
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公开(公告)号：US06903072B2
公开(公告)日：2005-06-07
申请号：US09345373
申请日：1999-07-01
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , C07K14/50 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
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公开(公告)号：US06403557B1
公开(公告)日：2002-06-11
申请号：US08976315
申请日：1997-11-21
IPC分类号： A61K3818
CPC分类号： C07K14/50 , A01K67/027 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/026 , Y10S530/866
摘要： The present invention relates to a novel FGF-13 protein which is a member of the fibroblast growth factor (FGF) family. In particular, isolated nucleic acid molecules are provided encoding the human FGF-13 protein. FGF-13 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FGF-13 activity. Also provided are diagnostic methods for detecting FGF-13-related disorders and therapeutic methods for treating FGF-13-related disorders. Disclosed is a method of prolonging dopaminergic neuron survival.
摘要翻译： 本发明涉及作为成纤维细胞生长因子（FGF）家族成员的新型FGF-13蛋白。 特别地，提供编码人FGF-13蛋白的分离的核酸分子。 还提供FGF-13多肽，载体，宿主细胞以及用于制备其的重组方法。 本发明还涉及用于鉴定FGF-13活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测FGF-13相关病症的诊断方法和用于治疗FGF-13相关疾病的治疗方法。 公开了延长多巴胺能神经元存活的方法。
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公开(公告)号：US06368822B1
公开(公告)日：2002-04-09
申请号：US09036985
申请日：1998-03-09
IPC分类号： C12P2106
摘要： Disclosed is a human Fibroblast growth factor-13 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage associated with stroke and due to neuronal disorders and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译： 公开了人成纤维细胞生长因子-13多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止与中风相关的神经元损伤以及由于神经元紊乱并促进神经元生长，并且防止皮肤老化和脱发，以刺激 血管生成，早期胚胎中胚层诱导和肢体再生。 还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。
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公开(公告)号：US06693077B1
公开(公告)日：2004-02-17
申请号：US09610651
申请日：2000-06-30
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian NI , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian NI , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K3818
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。
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