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1.发明申请Antibody inhibiting stem cell factor activity and use for treatment of asthma 审中-公开抗体抑制干细胞因子活性和用于治疗哮喘公开(公告)号：US20050112698A1
公开(公告)日：2005-05-26
申请号：US10867506
申请日：2004-06-14
申请人： Steven Neben , Toshihiko Takeuchi , Adrian Tomkinson , Kathy Delaria , Kelly Yan , Teresa Wong , Malinda Longphre
发明人： Steven Neben , Toshihiko Takeuchi , Adrian Tomkinson , Kathy Delaria , Kelly Yan , Teresa Wong , Malinda Longphre
IPC分类号： C07K16/22 , G01N33/564 , G01N33/53 , C12N5/06 , G01N33/567
CPC分类号： G01N33/564 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73
摘要： The present invention provides human antibodies specific for stem cell factor that contain at least one CDR derived from a combinatorial antibody library. The invention also provides pharmaceutical compositions comprising the antibodies and methods of treating asthma. The invention further provides methods of detecting stem cell factor using the antibodies.
摘要翻译： 本发明提供对含有至少一种衍生自组合抗体文库的CDR的干细胞因子特异性的人抗体。 本发明还提供了包含抗体的药物组合物和治疗哮喘的方法。 本发明还提供了使用抗体检测干细胞因子的方法。
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公开(公告)号：US07285640B2
公开(公告)日：2007-10-23
申请号：US10320231
申请日：2002-12-16
IPC分类号： C07K16/00
CPC分类号： G01N33/564 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73
摘要： The present invention provides human antibodies specific for stem cell factor that contain at least one CDR derived from a combinatorial antibody library. The invention also provides pharmaceutical compositions comprising the antibodies and methods of treating asthma. The invention further provides methods of detecting stem cell factor using the antibodies.
摘要翻译： 本发明提供对含有至少一种衍生自组合抗体文库的CDR的干细胞因子特异性的人抗体。 本发明还提供了包含抗体的药物组合物和治疗哮喘的方法。 本发明还提供了使用抗体检测干细胞因子的方法。
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3.发明申请HUMAN IL-17F AND OTHER IL-17F-RELATED PROTEINS AND METHODS RELATED THERETO 审中-公开人IL-17F和其他与IL-17F相关的蛋白质及其相关方法公开(公告)号：US20090075884A1
公开(公告)日：2009-03-19
申请号：US12175336
申请日：2008-07-17
申请人： Kenneth Jacobs , Kerry Kelleher , McKeough Carlin , Samuel Goldman , Debra Pittman , Sha Mi , Steven Neben , Joanne Giannotti , Margaret M. Golden-Fleet
发明人： Kenneth Jacobs , Kerry Kelleher , McKeough Carlin , Samuel Goldman , Debra Pittman , Sha Mi , Steven Neben , Joanne Giannotti , Margaret M. Golden-Fleet
CPC分类号： C07K14/54 , A61K38/00 , C07K14/523
摘要： Polynucleotides encoding human CTLA-8 and related proteins are disclosed. Human CTLA-8 proteins and methods for their production are also disclosed. Methods of treatment using human CTLA-8 proteins, rat CTLA-8 proteins and herpesvirus herpes CTLA-8 proteins are also provided.
摘要翻译： 公开了编码人CTLA-8和相关蛋白的多核苷酸。 还公开了人CTLA-8蛋白及其生产方法。 还提供了使用人CTLA-8蛋白，大鼠CTLA-8蛋白和疱疹病毒疱疹CTLA-8蛋白的治疗方法。
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公开(公告)号：US6043344A
公开(公告)日：2000-03-28
申请号：US34810
申请日：1998-03-04
申请人： Kenneth Jacobs , Kerry Kelleher , McKeough Carlin , Samuel Goldman , Debra Pittman , Sha Mi , Steven Neben , Joanne Giannotti , Margaret M. Golden-Fleet
发明人： Kenneth Jacobs , Kerry Kelleher , McKeough Carlin , Samuel Goldman , Debra Pittman , Sha Mi , Steven Neben , Joanne Giannotti , Margaret M. Golden-Fleet
CPC分类号： C07K14/54 , C07K14/523 , A61K38/00
摘要： Polynucleotides encoding human CTLA-8 and related proteins are disclosed. Human CTLA-8 proteins and methods for their production are also disclosed. Methods of treatment using human CTLA-8 proteins, rat CTLA-8 proteins and herpesvirus herpes CTLA-8 proteins are also provided.
摘要翻译： 公开了编码人CTLA-8和相关蛋白的多核苷酸。 还公开了人CTLA-8蛋白及其生产方法。 还提供了使用人CTLA-8蛋白，大鼠CTLA-8蛋白和疱疹病毒疱疹CTLA-8蛋白的治疗方法。
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5.发明申请Antibodies to human IL-17F and other CTLA-8-related proteins and methods related thereto 审中-公开人IL-17F和其他CTLA-8相关蛋白的抗体及其相关方法公开(公告)号：US20050214315A1
公开(公告)日：2005-09-29
申请号：US11034843
申请日：2005-01-14
申请人： Kenneth Jacobs , Kerry Kelleher , McKeough Carlin , Samuel Goldman , Debra Pittman , Sha Mi , Steven Neben , Joanne Giannotti , Margaret Golden-Fleet
发明人： Kenneth Jacobs , Kerry Kelleher , McKeough Carlin , Samuel Goldman , Debra Pittman , Sha Mi , Steven Neben , Joanne Giannotti , Margaret Golden-Fleet
CPC分类号： C07K14/54 , A61K38/00 , C07K14/523
摘要： Polynucleotides encoding human CTLA-8 (now known as IL-17F) and related proteins are disclosed. Human CTLA-8 and related proteins, including anti-human IL-17F antibodies, and methods for their production are also disclosed. Methods of treatment using human CTLA-8 and related proteins, rat CTLA-8 proteins and herpes CTLA-8 proteins are also provided.
摘要翻译： 公开了编码人CTLA-8（现在称为IL-17F）和相关蛋白的多核苷酸。 还公开了人CTLA-8和相关蛋白质，包括抗人IL-17F抗体及其生产方法。 还提供了使用人CTLA-8和相关蛋白，大鼠CTLA-8蛋白和疱疹CTLA-8蛋白的治疗方法。
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公开(公告)号：US06902735B1
公开(公告)日：2005-06-07
申请号：US10102080
申请日：2002-03-19
申请人： Kenneth Jacobs , Kerry Kelleher , McKeough Carlin , Samuel Goldman , Debra Pittman , Sha Mi , Steven Neben , Joanne Giannotti , Margaret M. Golden-Fleet
发明人： Kenneth Jacobs , Kerry Kelleher , McKeough Carlin , Samuel Goldman , Debra Pittman , Sha Mi , Steven Neben , Joanne Giannotti , Margaret M. Golden-Fleet
CPC分类号： C07K14/54 , A61K38/00 , C07K14/523
摘要： Polynucleotides encoding human CTLA-8 (now known as IL-17F) and related proteins are disclosed. Human CTLA-8 and related proteins, including anti-human IL-17F antibodies, and methods for their production are also disclosed. Methods of treatment using human CTLA-8 proteins, rat CTLA-8 proteins and herpes CTLA-8 proteins are also provided.
摘要翻译： 公开了编码人CTLA-8（现在称为IL-17F）和相关蛋白的多核苷酸。 还公开了人CTLA-8和相关蛋白质，包括抗人IL-17F抗体及其生产方法。 还提供了使用人CTLA-8蛋白，大鼠CTLA-8蛋白和疱疹CTLA-8蛋白的治疗方法。
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公开(公告)号：US6074849A
公开(公告)日：2000-06-13
申请号：US685239
申请日：1996-07-18
申请人： Kenneth Jacobs , Kerry Kelleher , McKeough Carlin , Samuel Goldman , Debra Pittman , Sha Mi , Steven Neben , Joanne Giannotti , Margaret M. Golden-Fleet
发明人： Kenneth Jacobs , Kerry Kelleher , McKeough Carlin , Samuel Goldman , Debra Pittman , Sha Mi , Steven Neben , Joanne Giannotti , Margaret M. Golden-Fleet
CPC分类号： C07K14/54 , C07K14/523 , A61K38/00
摘要： Polynucleotides encoding human CTLA-8 related proteins are disclosed. Human CTLA-8 proteins and methods for their production are also disclosed. Methods of treatment using human CTLA-8 proteins, rat CTLA-8 proteins and herpesvirus herpes CTLA-8 proteins are also provided.
摘要翻译： 公开了编码人CTLA-8相关蛋白的多核苷酸。 还公开了人CTLA-8蛋白及其生产方法。 还提供了使用人CTLA-8蛋白，大鼠CTLA-8蛋白和疱疹病毒疱疹CTLA-8蛋白的治疗方法。
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