公开(公告)号：US20050112698A1

公开(公告)日：2005-05-26

申请号：US10867506

申请日：2004-06-14

申请人： Steven Neben ,  Toshihiko Takeuchi ,  Adrian Tomkinson ,  Kathy Delaria ,  Kelly Yan ,  Teresa Wong ,  Malinda Longphre

发明人： Steven Neben ,  Toshihiko Takeuchi ,  Adrian Tomkinson ,  Kathy Delaria ,  Kelly Yan ,  Teresa Wong ,  Malinda Longphre

IPC分类号： C07K16/22 ,  G01N33/564 ,  G01N33/53 ,  C12N5/06 ,  G01N33/567

CPC分类号： G01N33/564 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73

摘要： The present invention provides human antibodies specific for stem cell factor that contain at least one CDR derived from a combinatorial antibody library. The invention also provides pharmaceutical compositions comprising the antibodies and methods of treating asthma. The invention further provides methods of detecting stem cell factor using the antibodies.

摘要翻译： 本发明提供对含有至少一种衍生自组合抗体文库的CDR的干细胞因子特异性的人抗体。 本发明还提供了包含抗体的药物组合物和治疗哮喘的方法。 本发明还提供了使用抗体检测干细胞因子的方法。

公开(公告)号：US20050059590A1

公开(公告)日：2005-03-17

申请号：US10820559

申请日：2004-04-08

申请人： Clark Pan ,  Steve Roczniak ,  Jeffrey Greve ,  Stephanie Yung ,  Malinda Longphre ,  Teresa Wong ,  Adrian Tomkinson

发明人： Clark Pan ,  Steve Roczniak ,  Jeffrey Greve ,  Stephanie Yung ,  Malinda Longphre ,  Teresa Wong ,  Adrian Tomkinson

IPC分类号： A61K38/17 ,  C07K14/54 ,  C07K14/715 ,  C07H21/04

CPC分类号： A61K38/1709 ,  C07K14/5406 ,  C07K14/7155

摘要： This invention relates to modified IL-4 mutein receptor antagonists comprising an IL-4 mutein receptor antagonist coupled to polyethylene glycol. Related formulations and dosages and methods of administration thereof for therapeutic purposes are also provided. These modified IL-4 mutein receptor antagonists, compositions and methods provide a treatment option for those individuals afflicted with a respiratory disorder such as asthma by inhibiting IL-4 and IL-13-mediated airway hyperresponsiveness and eosinophilia. More particularly, these antagonists have an increased duration of effect versus unmodified IL-4RA by virtue of a greater plasma half-life.

摘要翻译： 本发明涉及包含与聚乙二醇偶联的IL-4突变蛋白受体拮抗剂的经修饰的IL-4突变蛋白受体拮抗剂。 还提供了用于治疗目的的相关制剂和剂量及其施用方法。 这些修饰的IL-4突变蛋白受体拮抗剂，组合物和方法通过抑制IL-4和IL-13介导的气道高反应性和嗜酸性粒细胞增多为患有呼吸系统疾病如哮喘的个体提供治疗选择。 更具体地，这些拮抗剂由于更大的血浆半衰期而对未改性的IL-4RA具有增加的作用持续时间。

公开(公告)号：US20060063236A1

公开(公告)日：2006-03-23

申请号：US11026396

申请日：2004-12-29

申请人： David Boisvert ,  Malinda Longphre ,  Teresa Wong ,  Sydney Zaremba

发明人： David Boisvert ,  Malinda Longphre ,  Teresa Wong ,  Sydney Zaremba

IPC分类号： C07H21/04 ,  C12P21/04 ,  C07K14/54

CPC分类号： C07K14/54

摘要： Chimeric polypeptide antagonists that include an interleukin-4 (IL-4) mutein linked to an interleukin-9 (IL-9) mutein are provided, as are polynucleotides encoding the IL-4 and IL-9 chimeric mutein antagonists. Also provided are methods of using the chimeric mutein antagonists and encoding polypeptides to reduce or inhibit the responsiveness of a cell to a cytokine such as IL-4, IL-9 and/or interleukin-13. Methods using the compositions to treat disorders such as pulmonary disorders (e.g., asthma) also are provided.

公开(公告)号：US20080052184A1

公开(公告)日：2008-02-28

申请号：US11892415

申请日：2007-08-22

申请人： Peter J. Junger ,  Teresa Wong

发明人： Peter J. Junger ,  Teresa Wong

IPC分类号： G06Q30/00

CPC分类号： G06Q30/08 ,  G06Q30/0601

摘要： The example embodiments herein relate to the field of electronic registration (ER) of purchased products and, more particularly, to an improved electronic registration system which enables online buyers and sellers (e.g. those participating in online auctions) to take advantage of the benefits associated with ER systems. The ER techniques enable buyers to determine whether the product for sale, for example, has been purchased through authorized channels, was stolen, is covered under a warranty, etc. Such techniques may be used with existing brick-and-mortar stores as well as online stores. Value may be added for buyers, sellers, auction houses, manufacturers, and/or contract service partners.

摘要翻译： 本文的示例性实施例涉及购买产品的电子注册（ER）领域，更具体地说，涉及一种改进的电子注册系统，其使在线购买者和卖家（例如参与在线拍卖的用户）能够利用与 ER系统。 ER技术使买方能够确定例如已经通过授权渠道购买的产品是否被盗，是在保修范围之内等等。这些技术可能与现有的实体店和 在线商店。 可以为买家，卖家，拍卖行，制造商和/或合同服务合作伙伴添加价值。