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![Biocatalytic asymmetric reduction in preparation of (S)-N-[5-(1,2-dihydroxy-ethyl)-pyrazinyl]-2,2-dimethyl-propionamide](/abs-image/US/2010/06/01/US07727750B2/abs.jpg.150x150.jpg)
1.发明授权Biocatalytic asymmetric reduction in preparation of (S)-N-[5-(1,2-dihydroxy-ethyl)-pyrazinyl]-2,2-dimethyl-propionamide 失效（S）-N- [5-（1,2-二羟基 - 乙基） - 吡嗪基] -2,2-二甲基 - 丙酰胺的制备中的生物催化不对称还原公开(公告)号：US07727750B2
公开(公告)日：2010-06-01
申请号：US12061925
申请日：2008-04-03
申请人： Steven Paul Hanlon , Hans Iding , Ernst Kupfer , Roumen Nikolaev Radinov , Lianhe Shu , Ping Wang
发明人： Steven Paul Hanlon , Hans Iding , Ernst Kupfer , Roumen Nikolaev Radinov , Lianhe Shu , Ping Wang
IPC分类号： C12P17/12 , C12P1/04 , C07D241/00
CPC分类号： C12P17/12 , C07D241/20 , Y02P20/55
摘要： The present invention relates to biocatalytic asymmetric reduction for the preparation of 2-amino-[5-(1-hydroxy-2-hydroxy or halogen-ethyl)]-pyrazine derivatives of the formula wherein R is lower alkylcarbonyl or an amino protecting group and R1 is hydroxy or halogen. The compounds are key intermediates in the manufacture of a glucokinase activator.
摘要翻译： 本发明涉及用于制备下式的2-氨基 - [5-（1-羟基-2-羟基或卤代 - 乙基）] - 吡嗪衍生物的生物催化不对称还原：其中R是低级烷基羰基或氨基保护基， R1是羟基或卤素。 这些化合物是制造葡糖激酶活化剂的关键中间体。
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![BIOCATALYTIC ASYMMETRIC REDUCTION IN PREPARATION OF (S)-N-[5-(1,2-DIHYDROXY-ETHYL)-PYRAZINYL]-2,2-DIMETHYL-PROPIONAMIDE](/abs-image/US/2008/10/09/US20080248537A1/abs.jpg.150x150.jpg)
2.发明申请BIOCATALYTIC ASYMMETRIC REDUCTION IN PREPARATION OF (S)-N-[5-(1,2-DIHYDROXY-ETHYL)-PYRAZINYL]-2,2-DIMETHYL-PROPIONAMIDE 失效（S）-N- [5-（1,2-二羟基 - 乙基） - 吡嗪基] -2,2-二甲基丙酰胺的生物化学不对称还原公开(公告)号：US20080248537A1
公开(公告)日：2008-10-09
申请号：US12061925
申请日：2008-04-03
申请人： Steven Paul Hanlon , Hans Iding , Ernst Kupfer , Roumen Nikolaev Radinov , Lianhe Shu , Ping Wang
发明人： Steven Paul Hanlon , Hans Iding , Ernst Kupfer , Roumen Nikolaev Radinov , Lianhe Shu , Ping Wang
IPC分类号： C12P17/12 , C07D241/28 , C07D241/20
CPC分类号： C12P17/12 , C07D241/20 , Y02P20/55
摘要： The present invention relates to biocatalytic asymmetric reduction for the preparation of 2-amino-[5-(1-hydroxy-2-hydroxy or halogen-ethyl)]-pyrazine derivatives of the formula wherein R is lower alkylcarbonyl or an amino protecting group and R1 is hydroxy or halogen. The compounds are key intermediates in the manufacture of a glucokinase activator.
摘要翻译： 本发明涉及用于制备下式的2-氨基 - [5-（1-羟基-2-羟基或卤代 - 乙基）] - 吡嗪衍生物的生物催化不对称还原：其中R是低级烷基羰基或氨基保护基， R 1是羟基或卤素。 这些化合物是制造葡糖激酶活化剂的关键中间体。
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