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    Compact, high-resolution, gamma ray imaging for scintimammography and other medical diagostic applications
    4.
    发明授权
    Compact, high-resolution, gamma ray imaging for scintimammography and other medical diagostic applications 失效
    紧凑，高分辨率的γ射线成像，用于闪烁扫描和其他医学诊断应用

    公开(公告)号：US5864141A

    公开(公告)日：1999-01-26

    申请号：US898731

    申请日：1997-07-23

    申请人： Stanislaw Majewski ,  Andrew G. Weisenberger ,  Randolph F. Wojcik ,  Daniela Steinbach

    发明人： Stanislaw Majewski ,  Andrew G. Weisenberger ,  Randolph F. Wojcik ,  Daniela Steinbach

    IPC分类号： G01T1/164 ,  G01T1/202 ,  G01T1/20

    CPC分类号： G01T1/1644 ,  A61B6/4258 ,  G01T1/202

    摘要： A high resolution gamma ray imaging device includes an aluminum housing, a lead screen collimator at an opened end of the housing, a crystal scintillator array mounted behind the lead screen collimator, a foam layer between the lead screen collimator and the crystal scintillator array, a photomultiplier window coupled to the crystal with optical coupling grease, a photomultiplier having a dynode chain body and a base voltage divider with anodes, anode wire amplifiers each connected to four anodes and a multi pin connector having pin connections to each anode wire amplifier. In one embodiment the crystal scintillator array includes a yttrium aluminum perovskite (YAP) crystal array. In an alternate embodiment, the crystal scintillator array includes a gadolinium oxyorthosilicate (GSO) crystal array.

    摘要翻译： 高分辨率伽马射线成像装置包括铝壳体，壳体开口端的引线屏准直器，安装在引线屏准直器后面的晶体闪烁体阵列，引线屏准直器和晶体闪烁体阵列之间的泡沫层， 光电倍增器窗口，其耦合到具有光耦合润滑脂的晶体，具有倍增极链体的光电倍增管和具有阳极的基极分压器，每个连接到四个阳极的阳极线放大器和具有到每个阳极线放大器的引脚连接的多针连接器。 在一个实施例中，晶体闪烁体阵列包括钇铝钙钛矿（YAP）晶体阵列。 在替代实施例中，晶体闪烁体阵列包括氧化硅酸钆（GSO）晶体阵列。

    Mini gamma camera, camera system and method of use
    6.
    发明授权
    Mini gamma camera, camera system and method of use 有权
    迷你伽马相机，相机系统及使用方法

    公开(公告)号：US06271525B1

    公开(公告)日：2001-08-07

    申请号：US09159177

    申请日：1998-09-23

    申请人： Stanislaw Majewski ,  Andrew G. Weisenberger ,  Randolph F. Wojcik

    发明人： Stanislaw Majewski ,  Andrew G. Weisenberger ,  Randolph F. Wojcik

    IPC分类号： G01T1202

    CPC分类号： G01T1/1642 ,  A61B6/4258 ,  G01T1/1644

    摘要： A gamma camera comprising essentially and in order from the front outer or gamma ray impinging surface: 1) a collimator, 2) a scintillator layer, 3) a light guide, 4) an array of position sensitive, high resolution photomultiplier tubes, and 5) printed circuitry for receipt of the output of the photomultipliers. There is also described, a system wherein the output supplied by the high resolution, position sensitive photomultipiler tubes is communicated to: a) a digitizer and b) a computer where it is processed using advanced image processing techniques and a specific algorithm to calculate the center of gravity of any abnormality observed during imaging, and c) optional image display and telecommunications ports.

    摘要翻译： 一种伽马照相机，其基本上和从前外射线或伽马射线的入射面依次包括：1）准直器，2）闪烁体层，3）光导，4）阵列的位置敏感的高分辨率光电倍增管和5 ）印刷电路，用于接收光电倍增管的输出。 还描述了一种系统，其中由高分辨率，位置敏感的光电多层管提供的输出被传送到：a）数字转换器和b）使用高级图像处理技术和特定算法来计算中心的计算机 在成像期间观察到的任何异常的重力，以及c）可选的图像显示和电信端口。

    Anatomic and functional imaging of tagged molecules in animals
    7.
    发明授权
    Anatomic and functional imaging of tagged molecules in animals 失效
    动物中标记分子的解剖和功能成像

    公开(公告)号：US07209579B1

    公开(公告)日：2007-04-24

    申请号：US10341715

    申请日：2003-01-14

    申请人： Andrew G. Weisenberger ,  Stanislaw Majewski ,  Michael J. Paulus ,  Shaun S. Gleason

    发明人： Andrew G. Weisenberger ,  Stanislaw Majewski ,  Michael J. Paulus ,  Shaun S. Gleason

    IPC分类号： G06K9/00

    CPC分类号： A61B6/032 ,  A61B5/1077 ,  A61B5/1127 ,  A61B6/037 ,  A61B6/08 ,  A61B6/5235 ,  A61B6/5247 ,  A61B2503/40

    摘要： A novel functional imaging system for use in the imaging of unrestrained and non-anesthetized small animals or other subjects and a method for acquiring such images and further registering them with anatomical X-ray images previously or subsequently acquired. The apparatus comprises a combination of an IR laser profilometry system and gamma, PET and/or SPECT, imaging system, all mounted on a rotating gantry, that permits simultaneous acquisition of positional and orientational information and functional images of an unrestrained subject that are registered, i.e. integrated, using image processing software to produce a functional image of the subject without the use of restraints or anesthesia. The functional image thus obtained can be registered with a previously or subsequently obtained X-ray CT image of the subject. The use of the system described herein permits functional imaging of a subject in an unrestrained/non-anesthetized condition thereby reducing the stress on the subject and eliminating any potential interference with the functional testing that such stress might induce.

    摘要翻译： 用于无限制和非麻醉的小动物或其他受试者的成像中的新型功能成像系统以及用于获取这些图像并进一步将它们与先前或随后获得的解剖X射线图像对准的方法。 该装置包括IR激光轮廓测量系统和全部安装在旋转台架上的伽马，PET和/或SPECT成像系统的组合，其允许同时获取被登记的无限制对象的位置和定向信息和功能图像， 即集成的，使用图像处理软件来产生受试者的功能图像而不使用约束或麻醉。 这样获得的功能图像可以与先前或随后获得的受试者的X射线CT图像对齐。 本文描述的系统的使用允许受试者在无限制/非麻醉状态下进行功能成像，从而减少受试者的压力并消除对这种应激可能诱发的功能测试的任何潜在干扰。

    Optical coupler
    8.
    发明授权
    Optical coupler 失效
    光耦合器

    公开(公告)号：US06750456B1

    公开(公告)日：2004-06-15

    申请号：US09577701

    申请日：2000-05-23

    申请人： Stanislaw Majewski ,  Andrew G. Weisenberger

    发明人： Stanislaw Majewski ,  Andrew G. Weisenberger

    IPC分类号： G01T120

    CPC分类号： G01T1/2002 ,  G01T1/1644

    摘要： In a camera or similar radiation sensitive device comprising a pixilated scintillation layer, a light guide and an array of position sensitive photomultiplier tubes, wherein there exists so-called dead space between adjacent photomultiplier tubes the improvement comprising a two part light guide comprising a first planar light spreading layer or portion having a first surface that addresses the scintillation layer and optically coupled thereto at a second surface that addresses the photomultiplier tubes, a second layer or portion comprising an array of trapezoidal light collectors defining gaps that span said dead space and are individually optically coupled to individual position sensitive photomultiplier tubes. According to a preferred embodiment, coupling of the trapezoidal light collectors to the position sensitive photomultiplier tubes is accomplished using an optical grease having about the same refractive index as the material of construction of the two part light guide.

    摘要翻译： 在包括像素化闪烁层，光导和位置敏感光电倍增管阵列的相机或类似的辐射敏感设备中，其中在相邻光电倍增管之间存在所谓的死空间，其改进包括两部分光导，包括第一平面 光扩散层或具有第一表面的部分，其处理闪烁层并在寻址光电倍增管的第二表面处光学耦合到其上;第二层或部分包括限定跨越所述死空间的间隙的梯形光收集器阵列，并且分别 光学耦合到单独的位置敏感光电倍增管。 根据优选实施例，使用具有与两部分光导的结构材料大致相同的折射率的光学润滑脂来实现梯形光收集器与位置敏感光电倍增管的耦合。

    Imaging method for monitoring delivery of high dose rate brachytherapy
    9.
    发明授权
    Imaging method for monitoring delivery of high dose rate brachytherapy 有权
    用于监测高剂量率近距离放射治疗的成像方法

    公开(公告)号：US08295910B1

    公开(公告)日：2012-10-23

    申请号：US11985680

    申请日：2007-11-16

    申请人： Andrew G. Weisenberger ,  Stanislaw Majewski

    发明人： Andrew G. Weisenberger ,  Stanislaw Majewski

    IPC分类号： A61B5/05

    CPC分类号： A61B6/12 ,  A61B6/022 ,  A61B6/4258 ,  A61B6/482 ,  A61B6/5235 ,  A61N5/1015 ,  A61N2005/1052

    摘要： A method for in-situ monitoring both the balloon/cavity and the radioactive source in brachytherapy treatment utilizing using at least one pair of miniature gamma cameras to acquire separate images of: 1) the radioactive source as it is moved in the tumor volume during brachytherapy; and 2) a relatively low intensity radiation source produced by either an injected radiopharmaceutical rendering cancerous tissue visible or from a radioactive solution filling a balloon surgically implanted into the cavity formed by the surgical resection of a tumor.

    摘要翻译： 一种使用至少一对微型γ照相机进行近距离放射治疗处理气囊/腔和放射源的现场监测方法，以获取单独的图像：1）放射源在近距离放射治疗期间在肿瘤体积中移动 ; 和2）由注射的放射性药物产生的相对低强度的辐射源，所述放射性药物使可见的癌组织或从外科手术植入通过手术切除肿瘤形成的腔中的放射性溶液的放射性溶液。

    Apparatus and method for high dose rate brachytherapy radiation treatment
    10.
    发明授权
    Apparatus and method for high dose rate brachytherapy radiation treatment 失效
    用于高剂量率近距离放射治疗的装置和方法

    公开(公告)号：US06847838B1

    公开(公告)日：2005-01-25

    申请号：US10247450

    申请日：2002-09-19

    申请人： Daniel J. Macey ,  Stanislaw Majewski ,  Andrew G. Weisenberger ,  Mark Frederick Smith ,  Brian James Kross

    发明人： Daniel J. Macey ,  Stanislaw Majewski ,  Andrew G. Weisenberger ,  Mark Frederick Smith ,  Brian James Kross

    IPC分类号： A61B19/00 ,  A61N5/10 ,  G01T1/161 ,  A61B5/05

    CPC分类号： A61N5/1027 ,  A61B2090/392 ,  A61N5/1048 ,  G01T1/161

    摘要： A method and apparatus for the in vivo location and tracking of a radioactive seed source during and after brachytherapy treatment. The method comprises obtaining multiple views of the seed source in a living organism using: 1) a single PSPMT detector that is exposed through a multiplicity of pinholes thereby obtaining a plurality of images from a single angle; 2) a single PSPMT detector that may obtain an image through a single pinhole or a plurality of pinholes from a plurality of angles through movement of the detector; or 3) a plurality of PSPMT detectors that obtain a plurality of views from different angles simultaneously or virtually simultaneously. The plurality of images obtained from these various techniques, through angular displacement of the various acquired images, provide the information required to generate the three dimensional images needed to define the location of the radioactive seed source within the body of the living organism.

    摘要翻译： 近距离放射治疗期间和之后的放射性种子源的体内定位和跟踪的方法和装置。 该方法包括：使用以下方式获得活体中的种子源的多个视图：1）通过多个针孔暴露的单个PSPMT检测器，从而从单个角度获得多个图像; 2）单个PSPMT检测器，其可以通过检测器的移动从多个角度通过单个针孔或多个针孔获得图像; 或3）多个PSPMT检测器，其同时或实际上同时从不同角度获得多个视图。 通过各种获取的图像的角位移获得的从这些各种技术获得的多个图像提供了生成在生物体的体内限定放射性种子源的位置所需的三维图像所需的信息。