公开(公告)号：US06847838B1

公开(公告)日：2005-01-25

申请号：US10247450

申请日：2002-09-19

申请人： Daniel J. Macey ,  Stanislaw Majewski ,  Andrew G. Weisenberger ,  Mark Frederick Smith ,  Brian James Kross

发明人： Daniel J. Macey ,  Stanislaw Majewski ,  Andrew G. Weisenberger ,  Mark Frederick Smith ,  Brian James Kross

IPC分类号： A61B19/00 ,  A61N5/10 ,  G01T1/161 ,  A61B5/05

CPC分类号： A61N5/1027 ,  A61B2090/392 ,  A61N5/1048 ,  G01T1/161

摘要： A method and apparatus for the in vivo location and tracking of a radioactive seed source during and after brachytherapy treatment. The method comprises obtaining multiple views of the seed source in a living organism using: 1) a single PSPMT detector that is exposed through a multiplicity of pinholes thereby obtaining a plurality of images from a single angle; 2) a single PSPMT detector that may obtain an image through a single pinhole or a plurality of pinholes from a plurality of angles through movement of the detector; or 3) a plurality of PSPMT detectors that obtain a plurality of views from different angles simultaneously or virtually simultaneously. The plurality of images obtained from these various techniques, through angular displacement of the various acquired images, provide the information required to generate the three dimensional images needed to define the location of the radioactive seed source within the body of the living organism.

摘要翻译： 近距离放射治疗期间和之后的放射性种子源的体内定位和跟踪的方法和装置。 该方法包括：使用以下方式获得活体中的种子源的多个视图：1）通过多个针孔暴露的单个PSPMT检测器，从而从单个角度获得多个图像; 2）单个PSPMT检测器，其可以通过检测器的移动从多个角度通过单个针孔或多个针孔获得图像; 或3）多个PSPMT检测器，其同时或实际上同时从不同角度获得多个视图。 通过各种获取的图像的角位移获得的从这些各种技术获得的多个图像提供了生成在生物体的体内限定放射性种子源的位置所需的三维图像所需的信息。

公开(公告)号：US06804325B1

公开(公告)日：2004-10-12

申请号：US10280699

申请日：2002-10-25

申请人： Mark Frederick Smith

发明人： Mark Frederick Smith

IPC分类号： A61B623

CPC分类号： G06T11/006 ,  A61B6/037 ,  G01T1/2985

摘要： An image reconstruction method comprising accepting coincidence datat from either a data file or in real time from a pair of detector heads, culling event data that is outside a desired energy range, optionally saving the desired data for each detector position or for each pair of detector pixels on the two detector heads, and then reconstructing the image either by backprojection image reconstruction or by iterative image reconstruction. In the backprojection image reconstruction mode, rays are traced between centers of lines of response (LOR's), counts are then either allocated by nearest pixel interpolation or allocated by an overlap method and then corrected for geometric effects and attenuation and the data file updated. If the iterative image reconstruction option is selected, one implementation is to compute a grid Siddon retracing, and to perform maximum likelihood expectation maiximization (MLEM) computed by either: a) tracing parallel rays between subpixels on opposite detector heads; or b) tracing rays between randomized endpoint locations on opposite detector heads.

摘要翻译： 一种图像重建方法，包括从数据文件或实时地从一对检测器头接收重合数据，剔除超出期望能量范围的事件数据，可选地保存每个检测器位置的所需数据或每对检测器 像素，然后通过反投影图像重建或迭代图像重建来重建图像。 在反投影图像重建模式中，光线在响应线（LOR）的中心之间进行跟踪，然后通过最近的像素插值分配计数或通过重叠方法分配，然后对几何效应和衰减进行校正，并更新数据文件。 如果选择迭代图像重建选项，则一个实现是计算网格Siddon回溯，并执行通过以下两项计算的最大似然期望换算（MLEM）：a）在相对的检测器头上的子像素之间追踪平行光线; 或b）在相对的检测器头上的随机终点位置之间追踪光线。

公开(公告)号：US20100316275A1

公开(公告)日：2010-12-16

申请号：US12456372

申请日：2009-06-16

申请人： Alexander V. Stolin ,  John E. McKisson ,  Seung Joon Lee ,  Mark Frederick Smith

发明人： Alexander V. Stolin ,  John E. McKisson ,  Seung Joon Lee ,  Mark Frederick Smith

IPC分类号： G06K9/00

CPC分类号： G06T11/006 ,  A61B6/037 ,  A61B6/508 ,  A61B6/5264 ,  A61B6/583 ,  G01T1/1648 ,  G06T2211/412 ,  G06T2211/424

摘要： A method for image reconstruction of moving radionuclide distributions. Its particular embodiment is for single photon emission computed tomography (SPECT) imaging of awake animals, though its techniques are general enough to be applied to other moving radionuclide distributions as well. The invention eliminates motion and blurring artifacts for image reconstructions of moving source distributions. This opens new avenues in the area of small animal brain imaging with radiotracers, which can now be performed without the perturbing influences of anesthesia or physical restraint on the biological system.

摘要翻译： 运动放射性核素分布的图像重建方法。 其特别的实施例是用于清醒动物的单光子发射计算机断层摄影（SPECT）成像，尽管其技术也足以应用于其他运动的放射性核素分布。 本发明消除了用于移动源分布的图像重建的运动和模糊伪影。 这在放射性示踪剂的小动物脑成像领域开辟了新的途径，现在可以在没有麻醉或物理限制对生物系统的扰动影响的情况下进行。

公开(公告)号：US08335363B2

公开(公告)日：2012-12-18

申请号：US12456372

申请日：2009-06-16

申请人： Alexander V. Stolin ,  John E. McKisson ,  Seung Joon Lee ,  Mark Frederick Smith

发明人： Alexander V. Stolin ,  John E. McKisson ,  Seung Joon Lee ,  Mark Frederick Smith

IPC分类号： G06K9/00

CPC分类号： G06T11/006 ,  A61B6/037 ,  A61B6/508 ,  A61B6/5264 ,  A61B6/583 ,  G01T1/1648 ,  G06T2211/412 ,  G06T2211/424

摘要： A method for image reconstruction of moving radionuclide distributions. Its particular embodiment is for single photon emission computed tomography (SPECT) imaging of awake animals, though its techniques are general enough to be applied to other moving radionuclide distributions as well. The invention eliminates motion and blurring artifacts for image reconstructions of moving source distributions. This opens new avenues in the area of small animal brain imaging with radiotracers, which can now be performed without the perturbing influences of anesthesia or physical restraint on the biological system.

摘要翻译： 运动放射性核素分布的图像重建方法。 其特别的实施例是用于清醒动物的单光子发射计算机断层摄影（SPECT）成像，尽管其技术也足以应用于其他运动的放射性核素分布。 本发明消除了用于移动源分布的图像重建的运动和模糊伪影。 这在放射性示踪剂的小动物脑成像领域开辟了新的途径，现在可以在没有麻醉或物理限制对生物系统的扰动影响的情况下进行。

公开(公告)号：US09452238B2

公开(公告)日：2016-09-27

申请号：US10333973

申请日：2001-07-30

申请人： Brian Mark Thomson ,  Mark Frederick Smith ,  Charles William Archer ,  Gary Paul Dowthwaite

发明人： Brian Mark Thomson ,  Mark Frederick Smith ,  Charles William Archer ,  Gary Paul Dowthwaite

IPC分类号： A61F2/28 ,  A01N63/00 ,  C12N5/00 ,  A61L27/38 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/071 ,  A61F2/30 ,  A61K35/12

CPC分类号： A61L27/3817 ,  A61F2/30756 ,  A61F2002/30766 ,  A61K35/12 ,  A61L27/3852 ,  A61L2430/06 ,  C12N5/0068 ,  C12N5/0655 ,  C12N5/0662 ,  C12N5/0697 ,  C12N2501/15 ,  C12N2501/39 ,  C12N2501/42 ,  C12N2501/585 ,  C12N2502/1317 ,  C12N2502/1358 ,  C12N2502/1394 ,  C12N2509/00 ,  C12N2533/50 ,  C12N2533/52

摘要： An implant, artificial or semi-artificial at implantation, for repairing an articular cartilage and osteochondral defect site in a mammalian, such as a human. The implant having at least a first surface and a second surface. The first surface shaped for being press-fitted into the defect site to create an interface between the first surface and a bone-cartilage region of the defect site, and the second surface shaped for being press-fitted into the defect site to create an interface between the second surface and an articular cartilage region of the defect site. The implant being seeded, prior to implantation, with chondroprogenitor cells, including superficial zone chondroprogenitor cells.

摘要翻译： 在植入时人造或半人造植入物，用于修复哺乳动物（例如人）中的关节软骨和骨软骨缺损部位。 植入物具有至少第一表面和第二表面。 所述第一表面被成形为压入所述缺陷部位以在所述缺陷部位的所述第一表面和骨 - 软骨区域之间形成界面，所述第二表面被成形为压配合到所述缺陷部位以形成界面 在第二表面和缺损部位的关节软骨区域之间。 种植体在植入前接种，包括软骨祖细胞，包括表浅区软骨细胞。

公开(公告)号：US07332722B1

公开(公告)日：2008-02-19

申请号：US11358270

申请日：2006-02-21

申请人： Vi-Hoa Tran ,  Steven Richard Meikle ,  Mark Frederick Smith

发明人： Vi-Hoa Tran ,  Steven Richard Meikle ,  Mark Frederick Smith

IPC分类号： G01T1/161

CPC分类号： G01T1/1644 ,  A61B6/037 ,  A61B6/501 ,  A61B6/508

摘要： A method for calibrating multi-headed high sensitivity and high spatial resolution dynamic imaging systems, especially those useful in the acquisition of tomographic images of small animals. The method of the present invention comprises: simultaneously calibrating two or more detectors to the same coordinate system; and functionally correcting for unwanted detector movement due to gantry flexing.

摘要翻译： 一种用于校准多头高灵敏度和高空间分辨率动态成像系统的方法，特别是用于获取小动物断层图像的方法。 本发明的方法包括：同时校准两个或更多个检测器到同一坐标系; 并且功能性地校正由于台架弯曲而导致的不期望的检测器移动。