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1.发明授权Vacuum-assisted systems and methods for treating sphincters and adjoining tissue regions 有权真空辅助系统和治疗括约肌和邻近组织区域的方法公开(公告)号：US06325798B1
公开(公告)日：2001-12-04
申请号：US09304743
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin , Ronald Lax
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin , Ronald Lax
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2017/22067 , A61B2017/308 , A61B2017/3488 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/036 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods treat a tissue region at or near a sphincter by deploying a carrier, which carries an electrode that can be advanced to penetrate tissue. Negative pressure is applied through a suction port on the carrier near the electrode, to draw tissue in the tissue region inward against the carrier. The systems and methods advance the electrode to penetrate tissue drawn against the carrier. The vacuum anchors the surrounding tissue and mediates against the “tenting” of tissue during electrode penetration. Without tenting, the electrode penetrates mucosal tissue fully, to obtain a desired depth of penetration.
摘要翻译： 系统和方法通过展开携带可以被推进穿透组织的电极的载体来处理括约肌处或附近的组织区域。 通过电极附近的载体上的吸入口施加负压，将组织区域中的组织向内抵靠载体。 这些系统和方法使电极移动以穿透抵靠载体的组织。 真空锚定周围的组织，并在电极穿透期间抵抗组织的“隆起”进行介导。 没有隆起，电极完全渗透粘膜组织，以获得所需的穿透深度。
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2.发明授权Actively cooled electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions 有权用于形成损伤以治疗括约肌和邻近组织区域功能障碍的主动冷却电极组件公开(公告)号：US06440128B1
公开(公告)日：2002-08-27
申请号：US09304784
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin
IPC分类号： A61B1818
CPC分类号： A61B18/1485 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00029 , A61B2018/00035 , A61B2018/00065 , A61B2018/00214 , A61B2018/00238 , A61B2018/00267 , A61B2018/00553 , A61B2018/046 , A61B2018/1425 , A61B2018/1472 , A61B2218/002 , A61B2218/007
摘要： An assembly for treating tissue at or near the sphincter includes a support structure for deployment in a tissue region, and a an electrode carried by the support structure. The support structure includes a spine with a lumen having an exit port, the electrode being deployable from the exit port. The spine also includes a cooling lumen and as aspiration lumen to provide and remove fluids, respectively.
摘要翻译： 用于在括约肌处或附近处理组织的组件包括用于展开在组织区域中的支撑结构和由支撑结构承载的电极。 支撑结构包括具有出口的内腔的脊柱，电极可从出口端部分展开。 脊柱还包括冷却腔和分别用于提供和移除流体的抽吸腔。
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公开(公告)号：US06358245B1
公开(公告)日：2002-03-19
申请号：US09305123
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin
IPC分类号： A81B1804
CPC分类号： A61B18/1233 , A61B18/12 , A61B18/1206 , A61B18/14 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00035 , A61B2018/00077 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00488 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007 , Y10S128/922
摘要： Systems and methods deploy an electrode structure in contact with the tissue region. The electrode structure carries a sensor at a known location on the electrode structure to monitor an operating condition. The systems and methods provide an interface, which generate an idealized image of the electrode structure and an indicator image to represent the monitored operating condition in a spatial position on the idealized image corresponding to the location of the sensor on the electrode structure. The interface displays a view image comprising the idealized image and indicator image. The systems and methods cause the electrode structure to apply energy to heat the tissue region while the view image is displayed on the display screen.
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4.发明授权Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions 有权用于形成损伤以治疗括约肌和邻近组织区域功能障碍的可扩展电极组件公开(公告)号：US06258087B1
公开(公告)日：2001-07-10
申请号：US09304773
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Expandable assemblies for treating a tissue region at or near a sphincter comprises a support basket formed from an array of spines. A mechanism flexes the spines to expand and collapse the basket. Electrodes carried by the spines for advancement in a path to penetrate the tissue region upon expansion of the basket. The basket can be formed from a mechanical array of molded, jointed spines, or from an extruded tube having axial slits forming the spines.
摘要翻译： 用于治疗括约肌处或附近的组织区域的可扩展组件包括由脊柱阵列形成的支撑篮。 一种机构使脊柱弯曲以使筐膨胀和折叠。 由脊柱承载的电极，用于在通过篮子膨胀时穿过组织区域的路径前进。 篮子可以由模制的，接合的刺的机械阵列形成，或者由具有形成脊柱的轴向狭缝的挤压管形成。
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公开(公告)号：US06273886B1
公开(公告)日：2001-08-14
申请号：US09305079
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin
IPC分类号： A61B1804
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00041 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00494 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/143 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods integrate the control of an energy generator, to supply energy to an electrode structure to heat a tissue region, and the control of a pumping mechanism, to supply cooling fluid to control tissue temperature in the region.
摘要翻译： 系统和方法集成了能量发生器的控制，以向电极结构供应能量以加热组织区域，并且控制泵送机构，以供应冷却流体以控制该区域中的组织温度。
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公开(公告)号：US20050159743A1
公开(公告)日：2005-07-21
申请号：US11079697
申请日：2005-03-14
申请人： Stuart Edwards , David Utley , Ronald Lax , John Gaiser
发明人： Stuart Edwards , David Utley , Ronald Lax , John Gaiser
CPC分类号： A61B18/1492 , A61B18/1206 , A61B18/1477 , A61B18/18 , A61B2018/00011 , A61B2018/00029 , A61B2018/00047 , A61B2018/00214 , A61B2018/0022 , A61B2018/00494 , A61B2018/00553 , A61B2018/00666 , A61B2018/00678 , A61B2018/00684 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2218/002
摘要： A method for treating a sphincter provides a polymer material having a liquid state. The method also provides a catheter having a distal end, a tissue piercing device carried by the distal end, and an energy delivery device coupled to the tissue piercing device. The tissue piercing device has a lumen. The method introduces the catheter into an esophagus and pierces an exterior sphincter tissue surface within with the tissue piercing device. The method advances the tissue piercing device into an interior sphincter tissue site and conveys the polymer material while in a liquid state through the lumen into the interior sphincter tissue site. The method delivers energy to the tissue piercing device to transform the polymer material into a less liquid state within the interior sphincter tissue site, to thereby remodel the sphincter.
摘要翻译： 用于治疗括约肌的方法提供具有液体状态的聚合物材料。 该方法还提供了具有远端的导管，由远端承载的组织刺穿装置，以及耦合到组织刺穿装置的能量输送装置。 组织穿刺装置具有内腔。 该方法将导管引入食道并刺穿组织穿刺装置内的外括约肌组织表面。 该方法使组织穿刺装置进入内部括约肌组织部位，并将液体状态下的聚合物材料通过内腔输送到内括约肌组织部位。 该方法将能量传递到组织刺穿装置，以将聚合物材料转变成内部括约肌组织部位内的较少液体状态，从而改变括约肌。
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公开(公告)号：US20050107829A1
公开(公告)日：2005-05-19
申请号：US10963025
申请日：2004-10-12
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Qin
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Qin
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Methods treat a tissue region. In one arrangement, the methods deploy an electrode on a support structure in a tissue region at or near the cardia of the stomach. In one embodiment, the support structure has a proximal region and a distal region. The proximal region is enlarged in comparison to the distal region, and the electrode is carried by the enlarged proximal surface. The methods advance the electrode in a path to penetrate the tissue region and couple the electrode to a source of radio frequency energy to ohmically heat tissue and create a lesion in the tissue region.
摘要翻译： 方法治疗组织区域。 在一种布置中，所述方法将电极部署在胃贲门处或附近的组织区域中的支撑结构上。 在一个实施例中，支撑结构具有近端区域和远侧区域。 近端区域与远侧区域相比放大，并且电极由扩大的近侧表面承载。 所述方法使电极在路径中前进以穿透组织区域并将电极耦合到射频能量源以欧姆加热组织并在组织区域中产生损伤。
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公开(公告)号：US20060259029A1
公开(公告)日：2006-11-16
申请号：US11420714
申请日：2006-05-26
申请人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
发明人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Methods of accessing and ablating abnormal epithelium tissue in an alimentary canal are provided. The methods can include steps of (i) inserting an operative element into an alimentary canal such that the proximate to a portion of the alimentary canal having tissue to be ablated; and (ii) using the operative element to apply cryogenic ablation to a site of abnormal tissue.
摘要翻译： 提供了在消化道中获取和消融异常上皮组织的方法。 所述方法可以包括以下步骤：（i）将操作元件插入消化道，使得靠近消化道的一部分具有要消融的组织; 和（ii）使用手术元件将低温消融应用于异常组织的部位。
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9.发明申请Graphical user interface for association with an electrode structure deployed in contact with a tissue region 有权图形用户界面，用于与部署为与组织区域接触的电极结构相关联公开(公告)号：US20080097422A1
公开(公告)日：2008-04-24
申请号：US12001091
申请日：2007-12-10
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Qin , Peter Muller
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Qin , Peter Muller
IPC分类号： A61B18/12
CPC分类号： A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods deploy an electrode structure in contact with the tissue region. The electrode structure carries a sensor at a known location on the electrode structure to monitor an operating condition. The systems and methods provide an interface, which generate an idealized image of the electrode structure and an indicator image to represent the monitored operating condition in a spatial position on the idealized image corresponding to the location of the sensor on the electrode structure. The interface displays a view image comprising the idealized image and indicator image. The systems and methods cause the electrode structure to apply energy to heat the tissue region while the view image is displayed on the display screen.
摘要翻译： 系统和方法部署与组织区域接触的电极结构。 电极结构在电极结构上的已知位置处携带传感器以监测操作状态。 系统和方法提供了一种接口，其产生电极结构的理想化图像和指示图像，以在对应于电极结构上的传感器的位置的理想化图像上的空间位置中表示监视的操作条件。 界面显示包含理想图像和指示图像的视图。 当视觉图像显示在显示屏上时，系统和方法使电极结构施加能量来加热组织区域。
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公开(公告)号：US20060282071A1
公开(公告)日：2006-12-14
申请号：US11420722
申请日：2006-05-26
申请人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
发明人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Methods of ablating mucosal tissue in an alimentary canal are provided. The methods can include the steps of (i) providing an ablation device comprising a tissue ablation source; (ii) positioning at least a portion of the ablation device at a mucosal tissue surface of the alimentary canal; (iii) delivering a sufficient amount of the source for tissue ablation to the mucosal tissue surface to create a lesion in the mucosal tissue. In one implementation the methods include a step of providing a radiofrequency (RF) energy delivery device.
摘要翻译： 提供消化道中消融粘膜组织的方法。 所述方法可以包括以下步骤：（i）提供包括组织消融源的消融装置; （ii）将消融装置的至少一部分定位在消化道的粘膜组织表面; （iii）将足够量的用于组织消融的来源输送到粘膜组织表面以在粘膜组织中产生损伤。 在一个实现中，所述方法包括提供射频（RF）能量传递装置的步骤。
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