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公开(公告)号：US07262004B1
公开(公告)日：2007-08-28
申请号：US09487405
申请日：2000-01-18
申请人： Suman Preet Singh Khanuja , Ajit Kumar Shasany , Sunita Dhawan , Mahendra Pandurang Darokar , Sarita Satapathy , Tiruppadiripuliyur Ranganathan Santha Kumar , Dharmendra Saikia , Nirmal Kumar Patra , Janak Raj Bahl , Arun Kumar Tripathy , Sushil Kumar
发明人： Suman Preet Singh Khanuja , Ajit Kumar Shasany , Sunita Dhawan , Mahendra Pandurang Darokar , Sarita Satapathy , Tiruppadiripuliyur Ranganathan Santha Kumar , Dharmendra Saikia , Nirmal Kumar Patra , Janak Raj Bahl , Arun Kumar Tripathy , Sushil Kumar
IPC分类号： C12Q1/68
摘要： An in vitro screening method for identifying insect tolerant genotypes or clones is described. The method comprises growing plantlets in an in vitro system, screening the plantlets for molecular variation of somaclones using RAPD analysis in vitro, selecting the somaclones having molecular variation, exposing the somaclones to insect larvae or nymphs and identifying the surviving somaclones.
摘要翻译： 描述了用于鉴定耐受性基因型或克隆的体外筛选方法。 该方法包括在体外系统中种植小植株，在体外使用RAPD分析来筛选小鼠的分子变异的小植株，选择具有分子变异性的体细胞，将宿体菌暴露于昆虫幼虫或若虫并鉴定存活的体细胞。
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公开(公告)号：USPP14538P2
公开(公告)日：2004-02-17
申请号：US09482645
申请日：2000-01-18
申请人： Suman Preet Singh Khanuja , Ajit Kumar Shasany , Sunita Dhawan , Mahendra Pandurang Darokar , Sarita Satapathy , Tiruppadiripuliyur Ranganathan Santha Kumar , Dharmendra Saikia , Nirmal Kumar Patra , Janak Raj Bahl , Arun Kumar Tripathy , Sushil Kumar
发明人： Suman Preet Singh Khanuja , Ajit Kumar Shasany , Sunita Dhawan , Mahendra Pandurang Darokar , Sarita Satapathy , Tiruppadiripuliyur Ranganathan Santha Kumar , Dharmendra Saikia , Nirmal Kumar Patra , Janak Raj Bahl , Arun Kumar Tripathy , Sushil Kumar
IPC分类号： A01H500
CPC分类号： A01H5/02
摘要： The present invention relates to a novel, insect tolerant, high yielding essential oil and menthol yielding mint plant named ‘Sambhav’, which is a cultivar of Mentha arvensis L.. The mint plant of the present invention has been developed as a result of planned experiments which devised a procedure for early selection of somaclonal variants at the in vitro stage of the variety of Mentha arvensis.
摘要翻译： 本发明涉及一种新颖的耐昆虫高产精油和薄荷醇，产生名为“Sambhav”的薄荷植物，它是薄荷茶的品种。本发明的薄荷植物是由计划的结果而开发的 在Mentha arvensis的体外阶段设计了用于早期选择体细胞克隆变体的程序的实验。
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公开(公告)号：US06455079B1
公开(公告)日：2002-09-24
申请号：US09923586
申请日：2001-08-07
申请人： Suman Preet Singh Khanuja , Sarita Satapathy , Subhash Chandra Singh , Tiruppadiripuliyur Ranganathan Santha Kumar , Jai Shankar Arya , Arun Kumar Tripathy , Ajit Kumar Shasany , Mahendra Pandurang Darokar , Sushil Kumar
发明人： Suman Preet Singh Khanuja , Sarita Satapathy , Subhash Chandra Singh , Tiruppadiripuliyur Ranganathan Santha Kumar , Jai Shankar Arya , Arun Kumar Tripathy , Ajit Kumar Shasany , Mahendra Pandurang Darokar , Sushil Kumar
IPC分类号： A61K3538
CPC分类号： A01N65/20 , A01N65/00 , A01N2300/00 , A01N63/00 , A01N63/02
摘要： The present invention provides a novel synergistic composition comprising extract obtained from the plant Albizzia lebbeck together with Bacillus thuringiensis &dgr;-endotoxin, useful in controlling lepidopteran insects, methods for the preparation of the composition and application of the insecticidal composition to standing crops.
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4.发明授权Formulation comprising thymol useful in the treatment of drug resistant bacterial infections 失效包含可用于治疗耐药细菌感染的百里酚的制剂公开(公告)号：US06514541B2
公开(公告)日：2003-02-04
申请号：US09536124
申请日：2000-03-28
申请人： Suman Preet Singh Khanuja , Suchi Srivastava , Ajit Kumar Shasney , Mahendra Pandurang Darokar , Tiruppadiripuliyur Ranganathan Santha Kumar , Krishna Kumar Agarwal , Ateeque Ahmed , Nirmal Kumar Patra , Prachi Sinha , Sunita Dhawan , Dharmendra Saikia , Sushil Kumar
发明人： Suman Preet Singh Khanuja , Suchi Srivastava , Ajit Kumar Shasney , Mahendra Pandurang Darokar , Tiruppadiripuliyur Ranganathan Santha Kumar , Krishna Kumar Agarwal , Ateeque Ahmed , Nirmal Kumar Patra , Prachi Sinha , Sunita Dhawan , Dharmendra Saikia , Sushil Kumar
IPC分类号： A61K3578
CPC分类号： A61K36/23 , A61K36/534 , Y10S514/924 , A61K2300/00
摘要： A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.
摘要翻译： 一种可用于治疗耐药性细菌感染的制剂，其包含从植物Trachyspermum ammi获得的有效量的百里酚，含有从Mentha spicata和Mentha arvensis的杂种获得的适量的单萜和常规添加剂的薄荷油。 通过施用治疗有效量的制剂，通过混合上述成分和用于治疗患者耐药性的方法来制备制剂的方法。
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公开(公告)号：US06423541B1
公开(公告)日：2002-07-23
申请号：US09531768
申请日：2000-03-21
申请人： Suman Preet Singh Khanuja , Ajit Kumar Shasany , Sunita Dhawan , Mahendra Pandurang Darokar , Tiruppadiripuliyur Ranganathan Santha Kumar , Dharmendra Saikia , Arif Ali Naqui , Sushil Kumar
发明人： Suman Preet Singh Khanuja , Ajit Kumar Shasany , Sunita Dhawan , Mahendra Pandurang Darokar , Tiruppadiripuliyur Ranganathan Santha Kumar , Dharmendra Saikia , Arif Ali Naqui , Sushil Kumar
IPC分类号： C12N500
摘要： The invention provides a rapid in vitro method for selection of menthol rich mint genotypes from a large population of independent clones, said method comprising the steps of (i) raising a heterogeneous population of Mentha arvensis clones in vitro or by vegetative methods, (ii) transferring the plantlets/shoots to a basal medium, containing cytotoxic compounds in an amount sufficient to cause toxic effect in more than 95% of the clones, (iii) selecting surviving clones, their hardening in the glasshouse, transfer to field, reconfirmation of menthol tolerance through repeated in vitro assays, and (iv) multiplying selected clones and confirming genetic uniformity through RAPD analysis.
摘要翻译： 本发明提供了一种用于从大量独立克隆中选择富含薄荷醇的薄荷基因型的快速体外方法，所述方法包括以下步骤：（i）在体外或通过营养方法提高薄荷亚种克隆的异质群体，（ii） 将小植株/芽转移到基础培养基中，其含有足以在超过95％的克隆中引起毒性作用的细胞毒性化合物，（iii）选择存活的克隆，其在温室中的硬化，转移到野外，再次确认薄荷醇 通过重复体外测定的耐受性，以及（iv）通过RAPD分析来扩增选定的克隆并证实遗传均一性。
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6.发明授权Formulation comprising thymol useful in the treatment of drug resistant bacterial infections 失效包含可用于治疗耐药细菌感染的百里酚的制剂公开(公告)号：US06824795B2
公开(公告)日：2004-11-30
申请号：US10322731
申请日：2002-12-19
申请人： Suman Preet Singh Khanuja , Suchi Srivastava , Ajit Kumar Shasney , Mahendra Pandurang Darokar , Tiruppadiripuliyur Ranganathan Santha Kumar , Krishna Kumar Agarwal , Ateeque Ahmed , Nirmal Kumar Patra , Prachi Sinha , Sunita Dhawan , Dharmendra Saikia , Sushil Kumar
发明人： Suman Preet Singh Khanuja , Suchi Srivastava , Ajit Kumar Shasney , Mahendra Pandurang Darokar , Tiruppadiripuliyur Ranganathan Santha Kumar , Krishna Kumar Agarwal , Ateeque Ahmed , Nirmal Kumar Patra , Prachi Sinha , Sunita Dhawan , Dharmendra Saikia , Sushil Kumar
IPC分类号： A61K3578
CPC分类号： A61K36/23 , A61K36/534 , A61K2300/00
摘要： A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.
摘要翻译： 一种可用于治疗耐药性细菌感染的制剂，其包含从植物Trachyspermum ammi获得的有效量的百里酚，含有从Mentha spicata和Mentha arvensis的杂种获得的适量的单萜和常规添加剂的薄荷油。 通过施用治疗有效量的制剂，通过混合上述成分和用于治疗患者耐药性的方法来制备制剂的方法。
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7.发明授权公开(公告)号：US06420174B1
公开(公告)日：2002-07-16
申请号：US09536379
申请日：2000-03-28
申请人： Suman Preet Singh Khanuja , Ajit Kumar Shasany , Sunita Dhawan , Mahendra Pandurang Darokar , Tiruppadiripuliyur Ranganathan Santha Kumar , Dharmendra Saikia , Sushil Kumar
发明人： Suman Preet Singh Khanuja , Ajit Kumar Shasany , Sunita Dhawan , Mahendra Pandurang Darokar , Tiruppadiripuliyur Ranganathan Santha Kumar , Dharmendra Saikia , Sushil Kumar
IPC分类号： C12N500
摘要： The present invention is related to a method of producing organogenetic tissues from a plant of the genus Mentha, said method comprising the steps of culturing an explant from a plant of genus Mentha on an initiation medium in the presence of 400 to 600 lux light at a temperature of 23-27° C., with 16 hours of photoperiod, to obtain calli, transferring the calli to a basal medium comprising minerals and vitamins to ensure development of shoots, and culturing the shoots in a medium substantially free of growth hormones and containing menthol in a concentration of about 80 &mgr;g ml−1 to ensure root formation.
摘要翻译： 本发明涉及一种从薄荷属植物生产有机发育组织的方法，所述方法包括以下步骤：在400至600勒克斯光的存在下，在起始培养基上培养来自芒特属植物的外植体， 温度为23-27℃，光周期为16小时，以获得愈伤组织，将愈伤组织转移到包含矿物质和维生素的基础培养基中，以确保芽的发育，并在基本上不含生长激素的培养基中培养芽，并含有 浓缩约80毫升ml-1的薄荷醇以确保根形成。
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公开(公告)号：USPP13279P2
公开(公告)日：2002-11-26
申请号：US09721777
申请日：2000-11-27
申请人： Suman Preet Singh Khanuja , Sushil Kumar , Ajit Kumar Shasany , Sunita Dhawan , Mahendra Pandurang Darokar , Ali Arif Naqvi , Om Parkash Dhawan , Anil Kumar Singh , Nirmal Kumar Patra , Janak Raj Bahl , Ram Prakash Bansal
发明人： Suman Preet Singh Khanuja , Sushil Kumar , Ajit Kumar Shasany , Sunita Dhawan , Mahendra Pandurang Darokar , Ali Arif Naqvi , Om Parkash Dhawan , Anil Kumar Singh , Nirmal Kumar Patra , Janak Raj Bahl , Ram Prakash Bansal
IPC分类号： A01H500
CPC分类号： A01H5/12
摘要： This invention relates to a new and distinct mint plant of Mentha arvensis ‘Saksham’, developed through tissue culture, possessing the following combination of characters namely producing higher amount of menthol with high essential oil yield as well as herbage yield; possessing better growth and vegetative growth with high regenerability; has distinct molecular profile by random amplified polymorphic DNA (RAPD); retains the characteristics of tolerance to leaf spot, rust and powdery mildew as in the parent variety ‘Himalaya’; has light greenish leaves, pinkish white flowers like the parent plant ‘Himalaya’, this new plant is able to produce higher herbage, oil and menthol yield per unit area as compared to other existing improved varieties.
摘要翻译： 本发明涉及一种通过组织培养发展的薄荷植物新鲜不同的薄荷植物，具有以下组合，即产生较高含量的薄荷醇，具有高的精油产量，以及草本产量;具有更好的生长和营养 具有高可再生能力的生长;通过随机扩增多态性DNA（RAPD）具有不同的分子特征;保留了在母体品种“喜马拉雅”中对叶斑病，锈病和白粉病的耐受性的特征; 具有浅绿色的叶子，粉红色的白色花朵像母体植物“喜马拉雅”，与其他现有的改良品种相比，这种新植物能够产生比单位面积高的草药，油和薄荷肉产量。
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公开(公告)号：US06676974B2
公开(公告)日：2004-01-13
申请号：US10105794
申请日：2002-03-26
申请人： Suman Preet Singh Khanuja , Suchi Srivastava , Tiruppadiripuliyur Ranganathan Santha Kumar , Madan Mohan Gupta , Arvind Kumar Tripathy , Monika Singh , Janak Raj Bahl , Raj Kishori Lal , Mahendra Pandurang Darokar , Ajit Kumar Shasany , Sushil Kumar
发明人： Suman Preet Singh Khanuja , Suchi Srivastava , Tiruppadiripuliyur Ranganathan Santha Kumar , Madan Mohan Gupta , Arvind Kumar Tripathy , Monika Singh , Janak Raj Bahl , Raj Kishori Lal , Mahendra Pandurang Darokar , Ajit Kumar Shasany , Sushil Kumar
IPC分类号： A01N5906
CPC分类号： A61K36/899 , Y02A50/473
摘要： The present invention relates a hexane bioactive fraction and obtained from the roots of an aromatic plant named Vetiveria zizanioides commonly found in India for inhibiting the growth of drug resistant bacterial infections in humans and animals; also relates to a pharmaceutical composition comprising the bioactive extract with other additives for inhibiting the growth of drug resistant bacterial infections in humans and animals and a process for the isolation of said bioactive extract
摘要翻译： 本发明涉及己烷生物活性级分，其获自在印度通常发现的名为Vetiveria zizanioides的芳香植物的根，用于抑制人和动物中耐药细菌感染的生长; 还涉及一种药物组合物，其包含生物活性提取物与用于抑制人和动物中耐药细菌感染生长的其它添加剂和分离所述生物活性提取物的方法
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10.发明授权Method for the use of alpha arteether as an anti-bacterial and anti-fungal agent 有权使用αarteether作为抗菌和抗真菌剂的方法
公开(公告)号：US6127405A
公开(公告)日：2000-10-03
申请号：US179204
申请日：1998-10-27
申请人： Sushil Kumar , Suman Preet Singh Khanuja , Tiruppadiripuliyur Ranganathan Santha Kumar , Dharam Chand Jain , Suchi Srivastava , Asish Kumar Bhattacharya , Dharmendra Saikia , Ajit Kumar Shasany , Mahendra Pandurang Darokar , Ram Prakash Sharma
发明人： Sushil Kumar , Suman Preet Singh Khanuja , Tiruppadiripuliyur Ranganathan Santha Kumar , Dharam Chand Jain , Suchi Srivastava , Asish Kumar Bhattacharya , Dharmendra Saikia , Ajit Kumar Shasany , Mahendra Pandurang Darokar , Ram Prakash Sharma
IPC分类号： A61K31/352 , A61K31/335
CPC分类号： A61K31/352
摘要： The present invention relates to use .alpha.-arteether as a antibacterial agent, preferably for gyr mutant bacteria which are resistant to quinolone drugs and can be used as therapeutic agents for treating drug resistant bacterial infections, and also as a antifungal agent.
摘要翻译： 本发明涉及使用α-arteether作为抗菌剂，优选用于对喹诺酮药物具有抗性的gyr突变体细菌，并且可用作治疗药物抗性细菌感染的治疗剂，并且还可用作抗真菌剂。
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