公开(公告)号：US20070099993A1

公开(公告)日：2007-05-03

申请号：US11635339

申请日：2006-12-07

申请人： Suman Khanuja ,  Ranganathan Tiruppadiripuliyur ,  Vivek Gupta ,  Preeti Chand ,  Ankur Garg ,  Santosh Srivastava ,  Subash Verma ,  Dharmendra Saikia ,  Mahendra Darokar ,  Ajit Shasany ,  Anirban Pal

发明人： Suman Khanuja ,  Ranganathan Tiruppadiripuliyur ,  Vivek Gupta ,  Preeti Chand ,  Ankur Garg ,  Santosh Srivastava ,  Subash Verma ,  Dharmendra Saikia ,  Mahendra Darokar ,  Ajit Shasany ,  Anirban Pal

IPC分类号： A61K31/235

CPC分类号： A61K31/235

摘要： The present invention relates to the new use of an already known biomolecule methyl-β-orcinol carboxylate of formula I isolated from a lichen (Everniastrum cirrhatum), for treating pathogenic fungal infections of humans that are resistant to polyene and azole antibiotics such as amphotericin B, nystatin, clotrimazole etc.

摘要翻译： 本发明涉及分离自地衣（Everniastrum cirrhatum）的已知已知的式I的甲基-β-多酚羧酸盐的新用途，用于治疗对多烯和唑类抗生素如两性霉素B有抗性的人的致病性真菌感染 ，制霉菌素，克霉唑等

公开(公告)号：US06423541B1

公开(公告)日：2002-07-23

申请号：US09531768

申请日：2000-03-21

申请人： Suman Preet Singh Khanuja ,  Ajit Kumar Shasany ,  Sunita Dhawan ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Dharmendra Saikia ,  Arif Ali Naqui ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Ajit Kumar Shasany ,  Sunita Dhawan ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Dharmendra Saikia ,  Arif Ali Naqui ,  Sushil Kumar

IPC分类号： C12N500

CPC分类号： A01H1/04 ,  A01H5/12

摘要： The invention provides a rapid in vitro method for selection of menthol rich mint genotypes from a large population of independent clones, said method comprising the steps of (i) raising a heterogeneous population of Mentha arvensis clones in vitro or by vegetative methods, (ii) transferring the plantlets/shoots to a basal medium, containing cytotoxic compounds in an amount sufficient to cause toxic effect in more than 95% of the clones, (iii) selecting surviving clones, their hardening in the glasshouse, transfer to field, reconfirmation of menthol tolerance through repeated in vitro assays, and (iv) multiplying selected clones and confirming genetic uniformity through RAPD analysis.

摘要翻译： 本发明提供了一种用于从大量独立克隆中选择富含薄荷醇的薄荷基因型的快速体外方法，所述方法包括以下步骤：（i）在体外或通过营养方法提高薄荷亚种克隆的异质群体，（ii） 将小植株/芽转移到基础培养基中，其含有足以在超过95％的克隆中引起毒性作用的细胞毒性化合物，（iii）选择存活的克隆，其在温室中的硬化，转移到野外，再次确认薄荷醇 通过重复体外测定的耐受性，以及（iv）通过RAPD分析来扩增选定的克隆并证实遗传均一性。

公开(公告)号：US06858588B2

公开(公告)日：2005-02-22

申请号：US10403814

申请日：2003-03-31

申请人： Suman Preet Singh Khanuja ,  Jai Shanker Arya ,  Ranganathan Santha Kumar Tiruppadiripuliyur ,  Dharmendra Saikia ,  Harpreet Kaur ,  Monika Singh ,  Subhash Chandra Gupta ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Santosh Kumar Srivastava ,  Madan Mohan Gupta ,  Subash Chandra Verma ,  Anirban Pal

发明人： Suman Preet Singh Khanuja ,  Jai Shanker Arya ,  Ranganathan Santha Kumar Tiruppadiripuliyur ,  Dharmendra Saikia ,  Harpreet Kaur ,  Monika Singh ,  Subhash Chandra Gupta ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Santosh Kumar Srivastava ,  Madan Mohan Gupta ,  Subash Chandra Verma ,  Anirban Pal

IPC分类号： A61K31/704 ,  A61K45/06 ,  C07H15/06 ,  A61K31/70 ,  A61K31/7028 ,  C07C255/32 ,  C07H15/00

CPC分类号： C07H15/06 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (−) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.

摘要翻译： 本发明涉及名为NIAZIRIDIN的式I的新型腈糖苷及其类似物及其衍生物。 本发明还涉及一种通过生物活性指导的分离来自pod the的荚果分离下述式I的新型腈糖苷的方法，其命名为NIAZIRIDIN及其衍生物和类似物。 本发明特别涉及下述命名为NIAZIRIDIN及其衍生物和类似物的式I的新型腈糖苷增强常用抗生素如利福平，四环素和氨苄青霉素对革兰氏阳性（+）和（ - ）细菌的生物活性的生物增强活性。 生物分子还通过胃肠膜增强药物，维生素和营养素的吸收，增加其生物利用度。 因此，尼日吉林可以与药物和营养物联合使用，导致药物相关毒性降低，降低成本和化疗持续时间。

公开(公告)号：USPP16747P3

公开(公告)日：2006-07-04

申请号：US10840289

申请日：2004-05-07

申请人： Suman P. S. Khanuja ,  Sushil Kumar ,  Ajit K. Shasany ,  Sunita Dhawan ,  Mahendra P. Darokar ,  Arun K. Tripathy ,  Sarita Satapathy ,  Tiruppadiripuliyur R. S. Kumar ,  Vivek K. Gupta ,  Arvind K. Tripathi ,  Soumya Awasthi ,  Veena Prajapati ,  Ali A. Naqvi ,  Krishna K. Agrawal ,  Janak R. Bahl ,  Anil K. Singh ,  Ateeque Ahmed ,  Ravi P. Bansal ,  Alok Krishna ,  Dharmendra Saikia

发明人： Suman P. S. Khanuja ,  Sushil Kumar ,  Ajit K. Shasany ,  Sunita Dhawan ,  Mahendra P. Darokar ,  Arun K. Tripathy ,  Sarita Satapathy ,  Tiruppadiripuliyur R. S. Kumar ,  Vivek K. Gupta ,  Arvind K. Tripathi ,  Soumya Awasthi ,  Veena Prajapati ,  Ali A. Naqvi ,  Krishna K. Agrawal ,  Janak R. Bahl ,  Anil K. Singh ,  Ateeque Ahmed ,  Ravi P. Bansal ,  Alok Krishna ,  Dharmendra Saikia

IPC分类号： A01H5/00

CPC分类号： A01H5/12

摘要： The present invention relates to the development of a novel multiutility vigorously growing robust mint plant ‘Ganga’ of Mentha spicata L. var. viridis producing essential oil exhibiting anti-insect and anti-microbial activities and useful for agrochemical and pharmaceutical purposes.

摘要翻译： 本发明涉及一种新型多功能强力生长强壮薄荷植物“芒果”的发展。 具有抗昆虫和抗微生物活性的生物精油，用于农业化学和制药目的。

公开(公告)号：US20050181081A1

公开(公告)日：2005-08-18

申请号：US10761804

申请日：2004-01-21

申请人： Suman Khanuja ,  Pushplata Chaturvedi ,  Anil Singh ,  Ajit Shasany ,  Vinay Agarwal ,  Vivek Gupta ,  Subhash Gupta ,  Arun Tripathy ,  Anirban Pal ,  Dharmendra Saikia ,  Mahendra Darokar ,  Krishna Aggarwal ,  Ravi Bansal

发明人： Suman Khanuja ,  Pushplata Chaturvedi ,  Anil Singh ,  Ajit Shasany ,  Vinay Agarwal ,  Vivek Gupta ,  Subhash Gupta ,  Arun Tripathy ,  Anirban Pal ,  Dharmendra Saikia ,  Mahendra Darokar ,  Krishna Aggarwal ,  Ravi Bansal

IPC分类号： A61K36/00 ,  A61K36/534 ,  A61K36/54 ,  A61K36/8962 ,  A61K35/78

CPC分类号： A61K36/54 ,  A61K36/534 ,  A61K36/8962 ,  A61K2300/00

摘要： The present invention provides an improved preparation based on the synergistic action of garlic extract and essential oil of M. spicata var. Ganga or cinnamon oil against dermatophytic fungus. More particularly, the present invention relates to the synergistic enhancement of activity of a combination by menthyl acetate or Geraniol. The invention also provides a method of preparation of the synergistic combination and the shelf life observed to be more than one year. The cream based preparation is a potent anti-dermatophytic as described and illustrated by in vitro and in vivo evaluations.

摘要翻译： 本发明提供了一种改进的制剂，其基于大蒜提取物和M.spicata var。的精油的协同作用。 甘草或肉桂油抗皮肤真菌。 更具体地，本发明涉及通过乙酸薄荷酯或香叶醇组合的协同增强活性。 本发明还提供了一种制备协同组合的方法和观察到的一年以上的保质期。 基于乳膏的制剂是有效的抗皮肤真菌病，如通过体外和体内评价所描述和说明的。

公开(公告)号：US06824795B2

公开(公告)日：2004-11-30

申请号：US10322731

申请日：2002-12-19

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

IPC分类号： A61K3578

CPC分类号： A61K36/23 ,  A61K36/534 ,  A61K2300/00

摘要： A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.

摘要翻译： 一种可用于治疗耐药性细菌感染的制剂，其包含从植物Trachyspermum ammi获得的有效量的百里酚，含有从Mentha spicata和Mentha arvensis的杂种获得的适量的单萜和常规添加剂的薄荷油。 通过施用治疗有效量的制剂，通过混合上述成分和用于治疗患者耐药性的方法来制备制剂的方法。

公开(公告)号：US6127405A

公开(公告)日：2000-10-03

申请号：US179204

申请日：1998-10-27

申请人： Sushil Kumar ,  Suman Preet Singh Khanuja ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Dharam Chand Jain ,  Suchi Srivastava ,  Asish Kumar Bhattacharya ,  Dharmendra Saikia ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Ram Prakash Sharma

发明人： Sushil Kumar ,  Suman Preet Singh Khanuja ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Dharam Chand Jain ,  Suchi Srivastava ,  Asish Kumar Bhattacharya ,  Dharmendra Saikia ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Ram Prakash Sharma

IPC分类号： A61K31/352 ,  A61K31/335

CPC分类号： A61K31/352

摘要： The present invention relates to use .alpha.-arteether as a antibacterial agent, preferably for gyr mutant bacteria which are resistant to quinolone drugs and can be used as therapeutic agents for treating drug resistant bacterial infections, and also as a antifungal agent.

摘要翻译： 本发明涉及使用α-arteether作为抗菌剂，优选用于对喹诺酮药物具有抗性的gyr突变体细菌，并且可用作治疗药物抗性细菌感染的治疗剂，并且还可用作抗真菌剂。

公开(公告)号：US06514541B2

公开(公告)日：2003-02-04

申请号：US09536124

申请日：2000-03-28

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

IPC分类号： A61K3578

CPC分类号： A61K36/23 ,  A61K36/534 ,  Y10S514/924 ,  A61K2300/00

摘要： A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.

摘要翻译： 一种可用于治疗耐药性细菌感染的制剂，其包含从植物Trachyspermum ammi获得的有效量的百里酚，含有从Mentha spicata和Mentha arvensis的杂种获得的适量的单萜和常规添加剂的薄荷油。 通过施用治疗有效量的制剂，通过混合上述成分和用于治疗患者耐药性的方法来制备制剂的方法。

公开(公告)号：US09018226B2

公开(公告)日：2015-04-28

申请号：US13262040

申请日：2010-03-31

申请人： Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Dnyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

发明人： Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Dnyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

IPC分类号： A61K31/4375 ,  C07D491/22 ,  A61K36/24

CPC分类号： A61K36/24

摘要： The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and Serotonergic (5HT2A) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-demethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and α-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkaloids of formula 1 and 2 from the leaves of Rauwolfia tetraphylla. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions of R. tetraphylla and in the isolated compounds α-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS).

摘要翻译： 本发明涉及生物活性提取物，其部分和化合物从萝卜（Rauwolfia tetraphylla）分离。 基于动物模型的体内验证和针对抗精神病活性的多巴胺能D2，胆碱能（毒蕈碱）和血清素能（5HT2A）受体的比例结合亲和力，提取物和级分可用于治疗精神病。 本发明涉及式1和2的叶生物碱的新型抗精神病活性，命名为四氢奥斯汀，10-甲氧基四氢奥斯汀，异孢子甲苯胺，10-脱甲氧基甲苯胺，11-脱甲氧基苯甲苯胺，保留物和α-育亨宾。 本发明还涉及获得抗精神病药提取物以及分离来自萝卜（Rauwolfia tetraphylla）的叶的式1和2的生物碱的方法。 本发明特别涉及在四氢叶酸甲酯的MeOH提取物，乙酸乙酯和氯仿级分中以及在分离的化合物α-育亨宾，储存器中和以1:1.5比例混合的10-脱甲氧基对苯二胺和11-脱甲氧基苯甲苯胺中的显着的抗精神病活性，用于治疗 精神病没有任何额外的锥体症状（EPS）。

公开(公告)号：US20120184576A1

公开(公告)日：2012-07-19

申请号：US13262040

申请日：2010-03-31

申请人： Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Duyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

发明人： Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Duyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

IPC分类号： A61K31/4375 ,  C07D455/00 ,  A61P25/18 ,  A61K31/475

CPC分类号： A61K36/24

摘要： The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and Serotonergic (5HT2A) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-derαethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and α-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkabids of formula 1 and 2 from the leaves of Rauwolfia tetraphylla. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions of R. tetraphylla and in the isolated compounds α-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS). 1. R1=R2=OMe R3=β-H (Isoreserpiline) 2. R1=R2=OMe R3=β-H (Reserpiline) ″3. R1=OMe R2=HR3=β-H (11-Demethoxy reserpiline) ″4.R1=H R2=OMe R3=β-H (10-Demethoxy reserpiline) ″5. R1=R2=H R3=α-H (Tetrahydroalstonine) *7. R1=OMe R2=H R3=α-H (10-Methoxytetrahudroalstonine).

摘要翻译： 本发明涉及生物活性提取物，其部分和化合物从萝卜（Rauwolfia tetraphylla）分离。 基于动物模型的体内验证和针对抗精神病活性的多巴胺能D2，胆碱能（毒蕈碱）和血清素能（5HT2A）受体的比例结合亲和力，提取物和级分可用于治疗精神病。 本发明涉及式1和2的叶生物碱中的新型抗精神病活性，命名为四氢奥斯汀，10-甲氧基四氢奥斯汀，异丙基苯胺，10-脱乙氧基去甲苯胺，11-去甲氧基甲苯吡胺，储存蛋白和α-育亨宾。 本发明还涉及获得抗精神病药提取物以及分离来自罗非草（Rauwolfia tetraphylla）的叶子的式1和2的烷烃的方法。 本发明特别涉及在四氢叶酸甲酯的MeOH提取物，乙酸乙酯和氯仿级分中以及在分离的化合物α-育亨宾，储存器中和以1:1.5比例混合的10-脱甲氧基对苯二胺和11-脱甲氧基苯甲苯胺中的显着的抗精神病活性，用于治疗 精神病没有任何额外的锥体症状（EPS）。 R1 = R2 = OMe R3 =＆bgr; -H（Isoreserpiline）2.R1 = R2 = OMe R3 =＆bgr; -H（Reserpiline）“3。 R1 = OMe R2 = HR3 =＆bgr; -H（11-甲氧基乙酰胺）“4.R1 = H R2 = OMe R3 =＆bgr; -H（10-甲氧基乙胺） R1 = R2 = H R3 =α-H（四氢奥斯汀）* 7。 R1 = OMe R2 = H R3 =α-H（10-甲氧基四胡司汀）。