PREDICTING TOXICITY OF A COMPOUND OVER A RANGE OF CONCENTRATIONS
    7.
    发明申请
    PREDICTING TOXICITY OF A COMPOUND OVER A RANGE OF CONCENTRATIONS 有权
    化合物对浓度范围的预测毒性

    公开(公告)号:US20120219204A1

    公开(公告)日:2012-08-30

    申请号:US13402219

    申请日:2012-02-22

    IPC分类号: G06K9/00

    摘要: A method of predicting hepatotoxicity of a compound. The method includes imaging cells of hepatic origin positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of the compound, the imaging being performed using a quantitative high-content cell imaging system; quantitatively measuring the imaged cellular targets to detect changes in multiple cellular targets associated with cytotoxicity of the compound; and analyzing measurements obtained from the measured imaged cellular targets over a range of compound concentrations to determine the hepatotoxicity of the compound.

    摘要翻译: 一种预测化合物肝毒性的方法。 该方法包括成像位于多个容器内的肝源的细胞,以获得成像的细胞靶,每个容器用不同浓度的化合物处理,使用定量的高含量细胞成像系统进行成像; 定量测量成像的细胞靶标以检测与化合物的细胞毒性相关的多个细胞靶标的变化; 并且在化合物浓度的范围内分析从测量的成像细胞靶标获得的测量以确定化合物的肝毒性。

    Predicting toxicity of a compound over a range of concentrations
    8.
    发明授权
    Predicting toxicity of a compound over a range of concentrations 有权
    预测化合物在一定浓度范围内的毒性

    公开(公告)号:US08818070B2

    公开(公告)日:2014-08-26

    申请号:US13402219

    申请日:2012-02-22

    IPC分类号: G06K9/00

    摘要: A method of predicting hepatotoxicity of a compound. The method includes imaging cells of hepatic origin positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of the compound, the imaging being performed using a quantitative high-content cell imaging system; quantitatively measuring the imaged cellular targets to detect changes in multiple cellular targets associated with cytotoxicity of the compound; and analyzing measurements obtained from the measured imaged cellular targets over a range of compound concentrations to determine the hepatotoxicity of the compound.

    摘要翻译: 一种预测化合物肝毒性的方法。 该方法包括成像位于多个容器内的肝源的细胞,以获得成像的细胞靶,每个容器用不同浓度的化合物处理,使用定量的高含量细胞成像系统进行成像; 定量测量成像的细胞靶标以检测与化合物的细胞毒性相关的多个细胞靶标的变化; 并且在化合物浓度的范围内分析从测量的成像细胞靶标获得的测量以确定化合物的肝毒性。