-
公开(公告)号：US08822650B2
公开(公告)日：2014-09-02
申请号：US13087593
申请日：2011-04-15
申请人： Sung Youb Jung , Jin Sun Kim , Young Jin Park , Ki-Doo Choi , Se Chang Kwon , Gwan Sun Lee
发明人： Sung Youb Jung , Jin Sun Kim , Young Jin Park , Ki-Doo Choi , Se Chang Kwon , Gwan Sun Lee
IPC分类号： C12P21/08 , C07K16/00 , C07K19/00 , A61K47/48 , C07K16/46 , C07K14/505 , C07K14/56 , C07K14/61 , C07K14/535
CPC分类号： A61K47/68 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： Disclosed are a recombinant expression vector comprising a nucleotide sequence encoding an E. coli-derived signal sequence and a nucleotide sequence encoding an immunoglobulin constant region, and a transformant transformed with the expression vector. Also, disclosed is a method of mass-producing an immunoglobulin constant region by culturing the transformant and expressing the immunoglobulin constant region in a water-soluble form.
摘要翻译： 公开了包含编码大肠杆菌来源的信号序列的核苷酸序列和编码免疫球蛋白恒定区的核苷酸序列的重组表达载体和用表达载体转化的转化体。 此外，公开了通过培养转化体并以水溶性形式表达免疫球蛋白恒定区来大规模生产免疫球蛋白恒定区的方法。
-
公开(公告)号：US08029789B2
公开(公告)日：2011-10-04
申请号：US10535312
申请日：2004-11-13
申请人： Sung Youb Jung , Jin Sun Kim , Young Jin Park , Ki-Doo Choi , Se Chang Kwon , Gwan Sun Lee
发明人： Sung Youb Jung , Jin Sun Kim , Young Jin Park , Ki-Doo Choi , Se Chang Kwon , Gwan Sun Lee
CPC分类号： A61K47/68 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： Disclosed are a recombinant expression vector comprising a nucleotide sequence encoding an E. coli-derived signal sequence and a nucleotide sequence encoding an immunoglobulin constant region, and a transformant transformed with the expression vector. Also, disclosed is a method of mass-producing an immunoglobulin constant region by culturing the transformant and expressing the immunoglobulin constant region in a water-soluble form.
摘要翻译： 公开了包含编码大肠杆菌来源的信号序列的核苷酸序列和编码免疫球蛋白恒定区的核苷酸序列的重组表达载体和用表达载体转化的转化体。 此外，公开了通过培养转化体并以水溶性形式表达免疫球蛋白恒定区来大规模生产免疫球蛋白恒定区的方法。
-
3.发明申请PHARMACEUTICAL COMPOSITION FOR TREATING OBESITY-RELATED DISEASE COMPRISING INSULINOTROPIC PEPTIDE CONJUGATE 有权用于治疗包含胰岛素相关疾病的相关疾病的药物组合物公开(公告)号：US20100330108A1
公开(公告)日：2010-12-30
申请号：US12744660
申请日：2008-11-28
申请人： Dae Hae Song , Min Young Kim , Young Jin Park , Eun Hee Kang , Sung Youb Jung , Se Chang Kwon , Gwan Sun Lee
发明人： Dae Hae Song , Min Young Kim , Young Jin Park , Eun Hee Kang , Sung Youb Jung , Se Chang Kwon , Gwan Sun Lee
CPC分类号： C07K19/00 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K2319/30
摘要： The present invention relates to a composition for treating obesity-related diseases comprising an insulinotropic peptide conjugate, more particularly, to a composition for treating obesity-related diseases comprising a conjugate prepared by covalently linking the insulinotropic peptide with a carrier substance via a non-peptidyl linker, and a method for treating obesity-related diseases by using the same. In particular, the composition for treating obesity-related diseases according to the present invention remarkably improves the efficacy of suppressing food intake and its duration to reduce body weight and body fat, thereby being useful for the treatment of obesity-related diseases.
摘要翻译： 本发明涉及一种用于治疗肥胖相关疾病的组合物，其包括促胰岛素肽缀合物，更具体地，涉及用于治疗肥胖相关疾病的组合物，其包含通过非肽基共价连接促胰岛素肽与载体物质而制备的缀合物 接头，以及通过使用它们来治疗肥胖相关疾病的方法。 特别地，本发明的治疗肥胖相关疾病的组合物显着地提高了抑制食物摄取的效果及其减轻体重和体脂的持续时间，从而可用于治疗肥胖相关疾病。
-
4.发明授权Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate 有权用于治疗肥胖相关疾病的药物组合物，其包含促胰岛素肽缀合物公开(公告)号：US08263084B2
公开(公告)日：2012-09-11
申请号：US12744660
申请日：2008-11-28
申请人： Dae Hae Song , Min Young Kim , Young Jin Park , Eun Hee Kang , Sung Youb Jung , Se Chang Kwon , Gwan Sun Lee
发明人： Dae Hae Song , Min Young Kim , Young Jin Park , Eun Hee Kang , Sung Youb Jung , Se Chang Kwon , Gwan Sun Lee
IPC分类号： A61K39/395 , A61P5/50
CPC分类号： C07K19/00 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K2319/30
摘要： The present invention relates to a composition for treating obesity-related diseases comprising an insulinotropic peptide conjugate, more particularly, to a composition for treating obesity-related diseases comprising a conjugate prepared by covalently linking the insulinotropic peptide with a carrier substance via a non-peptidyl linker, and a method for treating obesity-related diseases by using the same. In particular, the composition for treating obesity-related diseases according to the present invention remarkably improves the efficacy of suppressing food intake and its duration to reduce body weight and body fat, thereby being useful for the treatment of obesity-related diseases.
摘要翻译： 本发明涉及一种用于治疗肥胖相关疾病的组合物，其包括促胰岛素肽缀合物，更具体地，涉及用于治疗肥胖相关疾病的组合物，其包含通过非肽基共价连接促胰岛素肽与载体物质而制备的缀合物 接头，以及通过使用它们来治疗肥胖相关疾病的方法。 特别地，本发明的治疗肥胖相关疾病的组合物显着地提高了抑制食物摄取的效果及其减轻体重和体脂的持续时间，从而可用于治疗肥胖相关疾病。
-
5.发明授权公开(公告)号：US09527898B2
公开(公告)日：2016-12-27
申请号：US14124969
申请日：2012-06-07
申请人： Sung Youb Jung , Myung Hyun Jang , Ling Ai Shen , Young Kyung Park , Young Jin Park , Se Chang Kwon
发明人： Sung Youb Jung , Myung Hyun Jang , Ling Ai Shen , Young Kyung Park , Young Jin Park , Se Chang Kwon
IPC分类号： A61K38/17 , C07K14/705 , A61P3/04 , C07K14/575 , C07K14/605 , A61K45/06 , A61K38/22 , A61K38/00
CPC分类号： C07K14/605 , A61K38/00 , A61K38/177 , A61K38/22 , A61K38/26 , A61K45/06 , C07K14/575 , C07K14/705
摘要： The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native oxyntomodulin, and a composition for the prevention or treatment of obesity comprising the peptide as an active ingredient. Unlike native oxyntomodulin, the novel peptide of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis with reduced side-effects, and also shows excellent receptor-activating effects. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
-
6.发明申请NOVEL OXYNTOMODULIN DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR TREATING OBESITY COMPRISING THE SAME 有权用于治疗包含其的肥胖症的新型氧化色氨酸衍生物和药物组合物公开(公告)号：US20140128318A1
公开(公告)日：2014-05-08
申请号：US14124969
申请日：2012-06-07
申请人： Sung Youb Jung , Myung Hyun Jang , Ling Ai Shen , Young Kyung Park , Young Jin Park , Se Chang Kwon
发明人： Sung Youb Jung , Myung Hyun Jang , Ling Ai Shen , Young Kyung Park , Young Jin Park , Se Chang Kwon
IPC分类号： C07K14/705 , A61K45/06 , A61K38/17
CPC分类号： C07K14/605 , A61K38/00 , A61K38/177 , A61K38/22 , A61K38/26 , A61K45/06 , C07K14/575 , C07K14/705
摘要： The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native oxyntomodulin, and a composition for the prevention or treatment of obesity comprising the peptide as an active ingredient. Unlike native oxyntomodulin, the novel peptide of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis with reduced side-effects, and also shows excellent receptor-activating effects. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
摘要翻译： 本发明涉及一种与天然胃泌酸调节素相比，胰高血糖素样肽-1受体和胰高血糖素受体的活性更优异的新型肽，以及用于预防或治疗包含该肽作为活性成分的肥胖症的组合物。 与本发明的胃泌酸调节蛋白不同，本发明的新型肽减少食物摄入，抑制胃排空，促进脂肪分解，副作用降低，并且还显示出优异的受体激活作用。 因此，可广泛用于治疗肥胖症的安全性和有效性。
-
7.发明授权公开(公告)号：US09487569B2
公开(公告)日：2016-11-08
申请号：US14124969
申请日：2012-06-07
申请人： Sung Youb Jung , Myung Hyun Jang , Ling Ai Shen , Young Kyung Park , Young Jin Park , Se Chang Kwon
发明人： Sung Youb Jung , Myung Hyun Jang , Ling Ai Shen , Young Kyung Park , Young Jin Park , Se Chang Kwon
IPC分类号： A61K38/17 , C07K14/705 , A61P3/04 , C07K14/575 , C07K14/605 , A61K45/06 , A61K38/22 , A61K38/00
摘要： The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native oxyntomodulin, and a composition for the prevention or treatment of obesity comprising the peptide as an active ingredient. Unlike native oxyntomodulin, the novel peptide of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis with reduced side-effects, and also shows excellent receptor-activating effects. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
-
公开(公告)号：US09492507B2
公开(公告)日：2016-11-15
申请号：US13638786
申请日：2011-04-04
申请人： Dae Hae Song , Jae Hee Shin , Young Jin Park , Dae Seong Im , Sung Min Bae , Se Chang Kwon
发明人： Dae Hae Song , Jae Hee Shin , Young Jin Park , Dae Seong Im , Sung Min Bae , Se Chang Kwon
CPC分类号： A61K38/28 , A61K47/68 , A61K47/6883 , C07K14/62 , C07K2319/30
摘要： The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
摘要翻译： 本发明涉及具有改善的体内持续时间和稳定性的胰岛素缀合物，其通过非肽基聚合物共价连接胰岛素与免疫球蛋白Fc区，包含其的长效制剂及其制备方法制备。 本发明的胰岛素结合物以较高水平保持肽的体内活性，并显着增加血清的半衰期，从而大大提高了胰岛素治疗后的药物依从性。
-
9.发明申请COMPOSITION FOR TREATING DIABETES COMPRISING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE 审中-公开用于治疗包含长效胰岛素结合剂和长效胰岛素诱导性糖尿病的糖尿病的组合物公开(公告)号：US20140120120A1
公开(公告)日：2014-05-01
申请号：US14123355
申请日：2012-06-01
申请人： Young Eun Woo , Myung Hyun Jang , Young Jin Park , Young Kyung Park , Chang Ki Lim , Se Chang Kwon
发明人： Young Eun Woo , Myung Hyun Jang , Young Jin Park , Young Kyung Park , Chang Ki Lim , Se Chang Kwon
CPC分类号： A61K38/26 , A61K38/28 , A61K47/68 , A61K47/6811 , A61K47/6883
摘要： The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved in-vivo duration of efficacy and stability.
摘要翻译： 本发明涉及一种用于预防或治疗糖尿病的组合物，其包含长效胰岛素缀合物和长效促胰岛素肽缀合物，以及用于治疗糖尿病的治疗方法，更具体地说， 作用胰岛素结合物和长效促胰岛素肽结合物抑制胰岛素治疗引起的体重增加，以及由促胰岛素肽治疗引起的呕吐和恶心，并减少所需的胰岛素剂量，从而显着提高药物依从性。 此外，本发明的长效胰岛素缀合物和长效促胰岛素肽缀合物中的每一种都是通过非肽基连接体将胰岛素或促胰岛素肽与免疫球蛋白Fc区连接而制备的，从而显示出改善的体内持续时间 功效和稳定性。
-
公开(公告)号：US20130028918A1
公开(公告)日：2013-01-31
申请号：US13638786
申请日：2011-04-04
申请人： Dae Hae Song , Jae Hee Shin , Young Jin Park , Dae Seong Im , Sung Min Bae , Se Chang Kwon
发明人： Dae Hae Song , Jae Hee Shin , Young Jin Park , Dae Seong Im , Sung Min Bae , Se Chang Kwon
IPC分类号： A61K39/395 , A61P3/10 , C07K16/00
CPC分类号： A61K38/28 , A61K47/68 , A61K47/6883 , C07K14/62 , C07K2319/30
摘要： The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
摘要翻译： 本发明涉及具有改善的体内持续时间和稳定性的胰岛素缀合物，其通过非肽基聚合物共价连接胰岛素与免疫球蛋白Fc区，包含其的长效制剂及其制备方法制备。 本发明的胰岛素结合物以较高水平保持肽的体内活性，并显着增加血清的半衰期，从而大大提高了胰岛素治疗后的药物依从性。
-
-
-
-
-
-
-
-
-
搜索结果
61 条记录 (耗时 0.049 秒)
