公开(公告)号：US06552196B2

公开(公告)日：2003-04-22

申请号：US09946541

申请日：2001-09-06

申请人： Sung-Joon Yoon ,  Yong-Ho Chung ,  Chi-Woo Lee ,  Yoon-Seok Oh ,  Nam-Doo Kim ,  Jae-Kyung Lim ,  Yoon-Ho Jin

发明人： Sung-Joon Yoon ,  Yong-Ho Chung ,  Chi-Woo Lee ,  Yoon-Seok Oh ,  Nam-Doo Kim ,  Jae-Kyung Lim ,  Yoon-Ho Jin

IPC分类号： C07D22104

CPC分类号： C07D487/10

摘要： The present invention relates to quinolonecarboxylic acid derivatives having more excellent and broad antibacterial activities than the existing quinolone-series antibiotic. More specifically, it pertains to novel quinolonecarboxylic acid derivative represented by following formula 1, which have a derivative of 7-[8-(alkoxyimino)-2,6-diazaspiro[3.4]oct-6-yl] as a substituent, and pharmaceutically acceptable salts and isomers thereof: Wherein A is C—H, C—F, C—Cl, C—O—CH3 or N; Y is H or amino; R1 is cyclopropyl or 2,4-difluorsophenyl R2 is C1-4 alkyl; and R3 is H or C1-4 alkyl.

摘要翻译： 本发明涉及具有比现有的喹诺酮系列抗生素更优异和更广泛的抗菌活性的喹诺酮羧酸衍生物。 更具体地说，涉及具有7- [8-（烷氧基亚氨基）-2,6-二氮杂螺[3.4]辛-6-基]作为取代基的衍生物的下式1所示的新型喹诺酮羧酸衍生物， 其可接受的盐和异构体：其中A是CH，CF，C-Cl，CO-CH 3或N; Y是H或氨基; R1是环丙基或2,4-二氟苯基R2是C1-4烷基; 且R 3为H或C 1-4烷基。

公开(公告)号：US06313299B1

公开(公告)日：2001-11-06

申请号：US09446697

申请日：1999-12-23

申请人： Sung-Joon Yoon ,  Yong-Ho Chung ,  Chi-Woo Lee ,  Yoon-Seok Oh ,  Nam-Doo Kim ,  Jae-Kyung Lim ,  Yoon-Ho Jin

发明人： Sung-Joon Yoon ,  Yong-Ho Chung ,  Chi-Woo Lee ,  Yoon-Seok Oh ,  Nam-Doo Kim ,  Jae-Kyung Lim ,  Yoon-Ho Jin

IPC分类号： C07D48710

CPC分类号： C07D487/10

摘要： The present invention relates to quinolonecarboxylic acid derivatives having more excellent and broad antibacterial activities than the existing quinolone-series antibiotics. More specifically, it pertains to novel quinolonecarboxylic acid derivatives represented by following formula 1, which have a derivative of 7-[8-(alkoxyimino)-2,6-diazaspiro[3.4]oct-6-yl] as a substituent, and pharmaceutically acceptable salts and isomers thereof: Wherein, A is C—H, C—F, C—Cl, C—O—CH3 or N; Y is H or amino; R1 is cyclopropyl or 2,4-difluorophenyl; R2 is C1-4 alkyl; and R3 is H or C1-4 alkyl.

摘要翻译： 本发明涉及具有比现有的喹诺酮系列抗生素更优异和更广泛的抗菌活性的喹诺酮羧酸衍生物。 更具体地说，涉及具有7- [8-（烷氧基亚氨基）-2,6-二氮杂螺[3.4]辛-6-基]作为取代基的衍生物的下式1所示的新型喹诺酮羧酸衍生物， 其中A为CH，CF，C-Cl，CO-CH 3或N; Y是H或氨基; R1是环丙基或2,4-二氟苯基; R2是C1-4烷基; 且R 3为H或C 1-4烷基。