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公开(公告)号：US5284947A
公开(公告)日：1994-02-08
申请号：US945302
申请日：1992-09-15
IPC分类号： C07D487/22 , A61K31/495
CPC分类号： C07D487/22
摘要： A compound having the structural formula ##STR1## or a pharmaceutically acceptable salts and prodrugs thereof, wherein R.sup.1 is selected from the group consisting of hydrogen and loweracyl, and R.sup.2 is selected from the group consisting of hydrogen, hydroxyl and methoxyl, as well as methods for the preparation and use thereof.
摘要翻译： 具有结构式“IMAGE”的化合物或其药学上可接受的盐和前药，其中R 1选自氢和低级酰基，R 2选自氢，羟基和甲氧基，以及方法 用于制备和使用。
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公开(公告)号：US5484799A
公开(公告)日：1996-01-16
申请号：US164234
申请日：1993-12-09
申请人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
发明人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
IPC分类号： C07D211/88 , A61K31/44 , A61K31/45 , C07D211/40 , C07D211/76
CPC分类号： C07D211/88
摘要： Novel antifungal and antitumor agents having the formula ##STR1## as well as pharmaceutically acceptable salts, esters, amides and pro-drugs thereof, wherein R is selected from the group consisting of ##STR2## Also disclosed are pharmaceutical compositions comprising such compounds, and methods of treatment and processes of manufacture relating thereto.
摘要翻译： 具有式（I）的新型抗真菌剂和抗肿瘤剂以及其药学上可接受的盐，酯，酰胺和前体药物，其中R选自由下列组成的组：IMAMA（Ia）和（IMA） Ib）还公开了包含这些化合物的药物组合物，与其有关的治疗方法和制造方法。
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公开(公告)号：US5589485A
公开(公告)日：1996-12-31
申请号：US429405
申请日：1995-04-26
申请人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
发明人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
IPC分类号： C07D211/88 , C07D211/40 , A61K31/44 , A61K31/445 , C07D211/76
CPC分类号： C07D211/88
摘要： Novel antifungal and antitumor agents having the formula ##STR1## as well as pharmaceutically acceptable salts, esters, amides and pro-drugs thereof, wherein R is selected from the group consisting of ##STR2## Also disclosed are pharmaceutical compositions comprising such compounds, and methods of treatment and processes of manufacture relating thereto.
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