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公开(公告)号：US5284947A
公开(公告)日：1994-02-08
申请号：US945302
申请日：1992-09-15
IPC分类号： C07D487/22 , A61K31/495
CPC分类号： C07D487/22
摘要： A compound having the structural formula ##STR1## or a pharmaceutically acceptable salts and prodrugs thereof, wherein R.sup.1 is selected from the group consisting of hydrogen and loweracyl, and R.sup.2 is selected from the group consisting of hydrogen, hydroxyl and methoxyl, as well as methods for the preparation and use thereof.
摘要翻译： 具有结构式“IMAGE”的化合物或其药学上可接受的盐和前药，其中R 1选自氢和低级酰基，R 2选自氢，羟基和甲氧基，以及方法 用于制备和使用。
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公开(公告)号：US5484799A
公开(公告)日：1996-01-16
申请号：US164234
申请日：1993-12-09
申请人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
发明人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
IPC分类号： C07D211/88 , A61K31/44 , A61K31/45 , C07D211/40 , C07D211/76
CPC分类号： C07D211/88
摘要： Novel antifungal and antitumor agents having the formula ##STR1## as well as pharmaceutically acceptable salts, esters, amides and pro-drugs thereof, wherein R is selected from the group consisting of ##STR2## Also disclosed are pharmaceutical compositions comprising such compounds, and methods of treatment and processes of manufacture relating thereto.
摘要翻译： 具有式（I）的新型抗真菌剂和抗肿瘤剂以及其药学上可接受的盐，酯，酰胺和前体药物，其中R选自由下列组成的组：IMAMA（Ia）和（IMA） Ib）还公开了包含这些化合物的药物组合物，与其有关的治疗方法和制造方法。
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公开(公告)号：US5589485A
公开(公告)日：1996-12-31
申请号：US429405
申请日：1995-04-26
申请人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
发明人： Jill E. Hochlowski , Marianna Jackson , Sunil K. Kadam , James P. Karwowski , James B. McAlpine
IPC分类号： C07D211/88 , C07D211/40 , A61K31/44 , A61K31/445 , C07D211/76
CPC分类号： C07D211/88
摘要： Novel antifungal and antitumor agents having the formula ##STR1## as well as pharmaceutically acceptable salts, esters, amides and pro-drugs thereof, wherein R is selected from the group consisting of ##STR2## Also disclosed are pharmaceutical compositions comprising such compounds, and methods of treatment and processes of manufacture relating thereto.
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公开(公告)号：US5585251A
公开(公告)日：1996-12-17
申请号：US370934
申请日：1995-01-10
摘要： Novel antifungal agents having the formula: ##STR1## wherein R is hydrogen or a radical of the formula ##STR2## and pharmaceutically acceptable prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.
摘要翻译： 具有下式的新颖的抗真菌剂：其中R是氢或下式的基团及其药学上可接受的前药，以及（i）包含这些化合物的药物组合物，（ii）使用这些化合物的治疗方法 ，和（iv）有用的方法和真菌培养物。
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公开(公告)号：US5773421A
公开(公告)日：1998-06-30
申请号：US548803
申请日：1995-12-21
申请人： Lisa A. Alder , Marianna Jackson , Neal S. Burres , James B. McAlpine , Jill E. Hochlowski , Larry L. Klein , Paul A. Lartey , Clinton Yeung
发明人： Lisa A. Alder , Marianna Jackson , Neal S. Burres , James B. McAlpine , Jill E. Hochlowski , Larry L. Klein , Paul A. Lartey , Clinton Yeung
IPC分类号： C12P17/06 , A01N43/16 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P31/10 , C07H15/10 , C07H17/04 , C12R1/645 , A61K31/71 , C07H15/00 , C12P19/44
摘要： Novel antifungal agents having the formula: ##STR1## wherein R is hydrogen or --C(O)--R.sub.1 wherein R.sub.1 is alkenyl, C.sub.2 -C.sub.12 -alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.
摘要翻译： 具有下式的新型抗真菌剂：其中R是氢或-C（O）-R1，其中R 1是烯基，C 2 -C 12烷基，芳基，芳基烯基，芳基烷基，芳基 - 芳基 - ，芳基烷氧基 芳基 - 芳基 - 芳基 - 芳基 - 芳基 - 芳基 - 或芳基烷氧基 - 芳基 - 芳基 - 或其药学上可接受的盐，酯或前药，以及（i）包含这些化合物的药物组合物，（ii） 使用这种化合物的治疗，以及（iv）可用于制备该化合物的方法和真菌培养物。
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公开(公告)号：US5192748A
公开(公告)日：1993-03-09
申请号：US740827
申请日：1991-08-05
申请人： Jill E. Hochlowski , Mark H. Buytendorp , Randal H. Chen , James B. McAlpine , Robert J. Theriault , Marianna Jackson , James P. Karwowski
发明人： Jill E. Hochlowski , Mark H. Buytendorp , Randal H. Chen , James B. McAlpine , Robert J. Theriault , Marianna Jackson , James P. Karwowski
CPC分类号： C07H13/04 , C07H15/26 , C07H7/02 , Y10S435/888
摘要： New antibiotics, unphenelfamycin and phenelfamycins A-D, are produced by microorganisms belonging to the genus Streptomyces. The antibiotics have antibacterial activity against gram-positive and gram-negative anaerobic organisms and are effective in improving the feed efficiency and growth rate of livestock, including poultry.
摘要翻译： 新型抗生素，非芬那霉素和苯丙胺霉素A-D由属于链霉菌属的微生物产生。 抗生素对革兰氏阳性和革兰氏阴性厌氧菌具有抗菌活性，有效提高家畜，包括家禽的饲料效率和生长速度。
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公开(公告)号：US4918174A
公开(公告)日：1990-04-17
申请号：US912438
申请日：1986-09-26
摘要： New compounds, tiacumicins, are produced by a microorganism belonging to the genus Dactylosporangium. The compounds are effective Gram-positive antibiotics.
摘要翻译： 新化合物，tiacumicins，由属于Dactylosporangium属的微生物产生。 这些化合物是有效的革兰氏阳性抗生素。
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公开(公告)号：US5767096A
公开(公告)日：1998-06-16
申请号：US678906
申请日：1996-07-12
CPC分类号： C07H17/08
摘要： Antimicrobial compounds having the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen and C.sub.1 -to-C.sub.4 alkanoyl; R.sup.3 and R.sup.4 are selected from the group consisting of (a) R.sup.3 is hydrogen and R.sup.4 is hydroxy, (b) R.sup.3 is hydroxy and R.sup.4 is hydrogen, (c) R.sup.3 and R.sup.4 taken together are .dbd.O; or selected from the group consisting of hydrogen and hydroxy; and R.sup.5 and R.sup.6 are independently selected from the group consisting of hydrogen, bromine and chlorine, with the proviso that at least one of R.sup.5 and R.sup.6 must be bromine. Also disclosed are pharmaceutical compositions comprising such compounds, methods of treating bacterial infection by the administration thereof and a process for preparing said compounds.
摘要翻译： 具有式“IMAGE”的抗微生物化合物，其中R 1和R 2独立地选自氢和C 1 -C 4烷酰基; R3和R4选自（a）R3是氢，R4是羟基，（b）R3是羟基，R4是氢，（c）R3和R4一起是= O; 或选自氢和羟基; 并且R 5和R 6独立地选自氢，溴和氯，条件是R 5和R 6中的至少一个必须是溴。 还公开了包含这些化合物的药物组合物，通过其给药治疗细菌感染的方法和制备所述化合物的方法。
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公开(公告)号：US5171740A
公开(公告)日：1992-12-15
申请号：US743311
申请日：1991-05-28
申请人： James B. McAlpine , Robert J. Theriault , James P. Karwowski , Marianna Jackson , Randal H. Chen
发明人： James B. McAlpine , Robert J. Theriault , James P. Karwowski , Marianna Jackson , Randal H. Chen
IPC分类号： C07H15/203 , C12P19/44
CPC分类号： C07H15/203 , C12P19/44 , Y10S435/822
摘要： A mixture of new coumamidine compounds are produced by a microorganism, belonging to the genus Saccharopolyspora. The compounds have antibiotic activity against a broad spectrum of bacteria.
摘要翻译： PCT No.PCT / US89 / 04556 Sec。 371日期1991年5月28日 102（e）日期1991年5月28日PCT 1989年10月10日提交PCT。由属于Saccharopolyspora属的微生物产生新的芳香胺化合物的混合物。 该化合物对广谱细菌具有抗生素活性。
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公开(公告)号：US5863773A
公开(公告)日：1999-01-26
申请号：US940513
申请日：1997-09-30
申请人： Geewananda P. Gunawardana , David Frost , Marianna Jackson , James P. Karwowski , Ronald R. Rasmussen
发明人： Geewananda P. Gunawardana , David Frost , Marianna Jackson , James P. Karwowski , Ronald R. Rasmussen
摘要： Disclosed are novel antifungal agents having the formula: ##STR1## as well as a pharmaceutically acceptable salt, ester of prodrug thereof, whereinR is: ##STR2## --C(O)--R.sub.1 wherein R.sub.1 is alkyl, alkenyl, aryl, arylalkenyl, aryl-aryl-, arylalkoxy-aryl-, aryl-aryl-aryl-, arylkoxy-aryl-aryl-, or ##STR3## wherein R.sub.2 is alkylamino, dialkylamino, (heterocyclic)alkyl, aryl, or arylalkyl; andX is O, NH, or NR.sub.3 wherein R.sub.3 is alkyl or aryl. Also disclosed are pharmaceutical compositions comprising a compound of the invention in combination with a pharmaceutically acceptable carrier; and a process for preparing the compounds of the invention.
摘要翻译： 公开了具有下式的新型抗真菌剂：其中R为：-C（O）-R1，其中R 1为烷基，烯基，芳基，芳基烯基， 芳基 - 芳基 - 芳基 - 芳基 - 芳基 - ，芳基 - 芳基 - 芳基 - ，芳基烷氧基 - 芳基 - 或其中R2是烷基氨基，二烷基氨基，（杂环）烷基，芳基或芳基烷基; 并且X是O，NH或NR 3，其中R 3是烷基或芳基。 还公开了包含本发明化合物与药学上可接受的载体组合的药物组合物; 以及制备本发明化合物的方法。
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