公开(公告)号：US20150374886A1

公开(公告)日：2015-12-31

申请号：US14753186

申请日：2015-06-29

Applicant: SurModics, Inc.

Inventor： Ralph A. Chappa ,  Kimberly K.M. Lindsoe

IPC: A61L31/16 ,  A61L31/14 ,  A61L31/10

CPC classification number: A61L31/16 ,  A61K6/0017 ,  A61K31/56 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/06

Abstract: The present invention relates to coatings with crystallized active agent(s) and related methods. In an embodiment, the invention includes a method for coating a medical device including selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. In an embodiment, the invention includes an elution control coating disposed on a medical device, the elution control coating including a polymer, and an active agent, wherein the active agent is at least about 80% crystallized within one week of being disposed on the medical device. In an embodiment, the invention includes a method for enhancing the formation of active agent crystals within a coating layer including forming a coating solution and adjusting the concentration of the active agent in the coating solution to reach some percentage of the active agent saturation point. In an embodiment, the invention includes a method of enhancing crystallization of an active agent, the method including forming a coating solution comprising a polymer, an active agent, and a solvent; applying the coating solution to a substrate; and increasing the rate of active agent nucleation within the coating.

Abstract translation: 本发明涉及具有结晶活性剂的涂层和相关方法。 在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括选择溶剂和聚合物，选择至少一定量饱和度的活性剂的浓度，形成具有选定浓度的活性剂的涂料组合物 ，并将所述涂料组合物施用于所述医疗装置。 在一个实施方案中，本发明包括设置在医疗装置上的洗脱控制涂层，洗脱控制涂层包括聚合物和活性剂，其中活性剂在被放置在医疗上的一周内至少约80％结晶 设备。 在一个实施方案中，本发明包括一种用于增强涂层内活性剂晶体形成的方法，包括形成涂层溶液并调节涂层溶液中活性剂的浓度达到活性剂饱和点的一定百分比。 在一个实施方案中，本发明包括增强活性剂结晶的方法，所述方法包括形成包含聚合物，活性剂和溶剂的包衣溶液; 将涂布溶液涂布到基材上; 并增加涂层内活性剂成核的速率。