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公开(公告)号：US09907981B2
公开(公告)日：2018-03-06
申请号：US15382401
申请日：2016-12-16
CPC分类号： A61N5/1077 , A61N2005/1087 , A61N2005/1095 , G21K1/02 , G21K1/10 , G21K5/04 , H01J27/16
摘要： The invention comprises a system for patient specific control of charged particles in a charged particle beam path using one or more trays inserted into the charged particle beam path, such as at the exit port of a gantry nozzle in close proximity to a tumor of a patient. Each tray holds an insert, such as a patient specific insert for controlling the energy, focus depth, and/or shape of the charged particle beam. Examples of inserts include a range shifter, a compensator, an aperture, a ridge filter, and a blank. Trays in a tray assembly are optionally retracted into an output nozzle of a charged particle cancer treatment system. Optionally and preferably, each tray communicates a held and positioned insert to a main controller of the charged particle cancer therapy system.
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公开(公告)号：US20170252580A1
公开(公告)日：2017-09-07
申请号：US15382401
申请日：2016-12-16
CPC分类号： A61N5/1077 , A61N2005/1087 , A61N2005/1095 , G21K1/02 , G21K1/10 , G21K5/04 , H01J27/16
摘要： The invention comprises a system for patient specific control of charged particles in a charged particle beam path using one or more trays inserted into the charged particle beam path, such as at the exit port of a gantry nozzle in close proximity to a tumor of a patient. Each tray holds an insert, such as a patient specific insert for controlling the energy, focus depth, and/or shape of the charged particle beam. Examples of inserts include a range shifter, a compensator, an aperture, a ridge filter, and a blank. Trays in a tray assembly are optionally retracted into an output nozzle of a charged particle cancer treatment system. Optionally and preferably, each tray communicates a held and positioned insert to a main controller of the charged particle cancer therapy system.
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3.发明申请PATIENT SPECIFIC BEAM CONTROL ASSEMBLY OF A CANCER THERAPY APPARATUS AND METHOD OF USE THEREOF 审中-公开癌症治疗装置的患者特异性束控制装置及其使用方法公开(公告)号：US20160317838A1
公开(公告)日：2016-11-03
申请号：US15207245
申请日：2016-07-11
CPC分类号： A61N5/1081 , A61B6/03 , A61B6/032 , A61B6/4216 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1039 , A61N5/1044 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a patient specific tray insert removably inserted into a tray frame to form a beam control tray assembly, which is removably inserted into a slot of a tray receiver assembly proximate a gantry nozzle of a charged particle cancer treatment system. Optionally, multiple tray inserts, each used to control a different beam state parameter, are inserted into corresponding slots of the tray receiver assembly where the multiple inserts are used to control beam intensity, shape, focus, and/or energy. The beam control tray assembling includes an identifier, such as an electromechanical identifier, of the particular insert type, which is communicated to a main controller, such as via the tray receiver assembly along with slot position and/or patient information.
摘要翻译： 本发明包括可移除地插入到托盘框架中的患者特定托盘插入件，以形成束控制托盘组件，其可移除地插入靠近带电粒子癌症治疗系统的门架喷嘴的托盘接收器组件的槽中。 可选地，将用于控制不同波束状态参数的多个托盘插入件插入托盘接收器组件的相应插槽中，其中多个插入件用于控制波束强度，形状，焦点和/或能量。 光束控制托盘组装包括特定插入物类型的诸如机电标识符的标识符，其被传送到主控制器，例如经由托盘接收器组件以及插槽位置和/或患者信息。
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4.发明授权公开(公告)号：US09744380B2
公开(公告)日：2017-08-29
申请号：US15207245
申请日：2016-07-11
CPC分类号： A61N5/1081 , A61B6/03 , A61B6/032 , A61B6/4216 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1039 , A61N5/1044 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a patient specific tray insert removably inserted into a tray frame to form a beam control tray assembly, which is removably inserted into a slot of a tray receiver assembly proximate a gantry nozzle of a charged particle cancer treatment system. Optionally, multiple tray inserts, each used to control a different beam state parameter, are inserted into corresponding slots of the tray receiver assembly where the multiple inserts are used to control beam intensity, shape, focus, and/or energy. The beam control tray assembling includes an identifier, such as an electromechanical identifier, of the particular insert type, which is communicated to a main controller, such as via the tray receiver assembly along with slot position and/or patient information.
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5.发明申请CHARGED PARTICLE CANCER THERAPY BEAM STATE DETERMINATION APPARATUS AND METHOD OF USE THEREOF 审中-公开充电颗粒癌治疗波束状态测定装置及其使用方法公开(公告)号：US20160317836A1
公开(公告)日：2016-11-03
申请号：US15207309
申请日：2016-07-11
CPC分类号： A61B6/4216 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1044 , A61N5/1067 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises an apparatus and method of use thereof for determining a charged particle beam state after passage through a final beam modification insert and prior to entering a patient, such as in cancer treatment or tomographic imaging. The insert comprises a range shifter, a known energy absorber, a ridge filter, a focal length altering insert, an aperture defining element, a compensator, and/or a patient specific beam modifier. The monitoring element comprises one or more sheets, configured to emit photons upon passage therethrough of the charged particle beam, where the emitted photons are detected, tested, such as against a predetermined cancer treatment plan, and/or used to aid in three dimensional tomographic image generation.
摘要翻译： 本发明包括一种其使用的装置及其方法，用于确定通过最终光束修改插入物之后并且在进入患者之前，例如癌症治疗或断层摄影成像中的带电粒子束状态。 插入件包括范围移位器，已知的能量吸收器，脊形过滤器，焦距改变插入件，孔限定元件，补偿器和/或患者特定光束修改器。 监测元件包括一个或多个片材，其构造成在穿过带电粒子束的过程中发射光子，其中发射的光子被检测，测试，例如针对预定的癌症治疗计划，和/或用于辅助三维断层摄影 图像生成。
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公开(公告)号：US11918830B2
公开(公告)日：2024-03-05
申请号：US17382044
申请日：2021-07-21
申请人： Susan L. Michaud , Daniel J. Raymond , Artur Teymurazyan , Ran Tu
发明人： Susan L. Michaud , Daniel J. Raymond , Artur Teymurazyan , Ran Tu
CPC分类号： A61N5/1077 , A61B6/03 , A61N5/1044 , A61N5/1067 , A61N5/1082 , G21K1/087 , G21K1/093 , G21K5/04 , A61N5/107 , A61N2005/1074 , A61N2005/1087 , A61N2005/1097 , H01J35/147
摘要： The invention comprises a method and apparatus for tuning a charged particle beam path of a charged particle beam system used to treat a tumor of a patient, comprising the steps of: positioning a two-dimensional charged particle detector in a beam line downstream from a magnet pair; operating windings of the magnet pair at a first power level to generate a first magnetic field; measuring a beam position with the first two-dimensional charged particle detector; adjusting a correction magnetic field by driving voltage of a correction coil at a second power level, the second power level less than five percent of the first power level, where the first magnetic field and the correction magnetic field combine to yield an operational magnetic field; and the steps of measuring and adjusting the correction magnetic field changing the operational magnetic field to adjust a measured beam position toward a target beam position.
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公开(公告)号：US20210387022A1
公开(公告)日：2021-12-16
申请号：US17383836
申请日：2021-07-23
申请人： Daniel J. Raymond , Artur Teymurazyan , Ran Tu , Susan L. Michaud
发明人： Daniel J. Raymond , Artur Teymurazyan , Ran Tu , Susan L. Michaud
摘要： The invention comprises a method and apparatus for aligning a charged particle beam path for treating a tumor of a patient, comprising: a cancer therapy system comprising the charged particle beam path sequentially passing: from an injector, through a synchrotron, along a beam transport line, and through a nozzle; a first two-dimensional detector configured to measure a beam state of positively charged particles; and an integrated intelligent system configured to classify the beam state into a set of beam shape factors, the integrated intelligent system configured to correct the beam shape through application of a condition-action rule: (1) adjusting a first voltage delivered to a first magnet positioned in the beam line prior to the first two-dimensional detector and (2) altering the beam shape through application of a second voltage to a second magnet position in the beam line adjacent to the first magnet.
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公开(公告)号：US10092776B2
公开(公告)日：2018-10-09
申请号：US15280999
申请日：2016-09-29
摘要： The invention comprises a method and apparatus for imaging a tumor of a patient using one or more imaging systems positionable about the tumor and treating the tumor using positively charged particles, such as a process of: (1) rotating a gantry support and/or gantry, connected to at least a portion of a beam transport system configured to pass a charged particle treatment beam, circumferentially about the patient and a gantry rotation axis; (2) translating a translatable imaging system past the patient on a path parallel to an axis perpendicular to the gantry rotation axis; (3) imaging the tumor using the translatable imaging system; and (4) treating the tumor using the rotatable treatment beam.
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9.发明申请INTEGRATED TRANSLATION/ROTATION CHARGED PARTICLE IMAGING/TREATMENT APPARATUS AND METHOD OF USE THEREOF 审中-公开集成翻译/旋转充电颗粒成像/处理设备及其使用方法公开(公告)号：US20170014647A1
公开(公告)日：2017-01-19
申请号：US15280999
申请日：2016-09-29
CPC分类号： A61N5/1067 , A61B6/032 , A61B6/4092 , A61B6/4216 , A61B6/4258 , A61B6/4266 , A61B6/467 , A61B6/5205 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1081 , A61N5/1082 , A61N2005/1052 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K5/04
摘要： The invention comprises a method and apparatus for imaging a tumor of a patient using one or more imaging systems positionable about the tumor and treating the tumor using positively charged particles, such as a process of: (1) rotating a gantry support and/or gantry, connected to at least a portion of a beam transport system configured to pass a charged particle treatment beam, circumferentially about the patient and a gantry rotation axis; (2) translating a translatable imaging system past the patient on a path parallel to an axis perpendicular to the gantry rotation axis; (3) imaging the tumor using the translatable imaging system; and (4) treating the tumor using the rotatable treatment beam.
摘要翻译： 本发明包括用于使用可定位在肿瘤周围的一个或多个成像系统使用带正电荷的颗粒来治疗肿瘤的患者肿瘤成像的方法和装置，例如：（1）旋转支架和/或龙门架 连接到梁传输系统的至少一部分，其配置成使带电粒子处理束沿周向围绕患者和台架旋转轴线传递; （2）在平行于垂直于所述台架旋转轴的轴的路径上翻译可翻译成像系统经过所述患者; （3）使用可翻译成像系统对肿瘤进行成像; 和（4）使用可旋转治疗束治疗肿瘤。
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公开(公告)号：US09782140B2
公开(公告)日：2017-10-10
申请号：US15257686
申请日：2016-09-06
CPC分类号： A61B6/5205 , A61B6/032 , A61B6/0457 , A61B6/4092 , A61B6/4258 , A61B6/4266 , A61B6/50 , A61N5/1037 , A61N5/1039 , A61N5/1044 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K1/10 , G21K5/04
摘要： The invention comprises a method and apparatus for imaging and treating a tumor of a patient using positively charged particles and X-rays. A mounting rail, supporting a scintillation detection system element and an X-ray detection system element, is alternatingly extended/retracted to position the required detection system element opposite a patient tumor position from an exit nozzle of a beam transport system connected to an accelerator of the positively charged particles, where the positively charged particles are alternatingly used to treat the tumor via irradiation. The mounting rail optionally rotates with rotation of the exit nozzle about the patient, such as with rotation of a support gantry.
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