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1.发明授权(3-(4-(aminomethyl)phenoxy or phenylthio)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone compounds 失效（3-（4-（氨基甲基）苯氧基或苯硫基）氮杂环丁烷-1-基）（5-苯基-1,3,4-恶二唑-2-基）甲酮化合物公开(公告)号：US08546375B2
公开(公告)日：2013-10-01
申请号：US13176554
申请日：2011-07-05
申请人： Susanne Doris Margit Bökman-Winiwarter , Marlene Fredenwall , Carl Anders Hogner , Lars Anders Mikael Johansson , Robert Andrew Judkins , Lanna Li , Björn Christian Ingvar Löfberg , Sverker Von Unge
发明人： Susanne Doris Margit Bökman-Winiwarter , Marlene Fredenwall , Carl Anders Hogner , Lars Anders Mikael Johansson , Robert Andrew Judkins , Lanna Li , Björn Christian Ingvar Löfberg , Sverker Von Unge
IPC分类号： A61K31/4245 , C07D295/155 , C07D413/12 , C07D205/04 , C07D413/14 , C07D295/096
CPC分类号： C07D413/06 , A61K31/4245 , C07D413/14
摘要： Disclosed herein are azetidinyl compounds of formula I, as described herein, pharmaceutical compositions comprising an azetidinyl compound, and a method of using an azetidinyl compound in the treatment or prophylaxis of a melanin-concentrating hormone related disease or condition.
摘要翻译： 本文公开的是式I的氮杂环丁烷基化合物，如本文所述，包含氮杂环丁烷基化合物的药物组合物和使用氮杂环丁烷基化合物在治疗或预防与黑色素浓缩激素相关的疾病或病症中的方法。
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2.发明申请(3-(4-(AMINOMETHYL)PHENOXY OR PHENYLTHIO)AZETIDIN-1-YL)(5-PHENYL-1,3,4-OXADIAZOL-2-YL)METHANONE COMPOUNDS 失效（3-（4-（氨基甲基）苯氧基或苯基）亚甲基-1-基）（5-苯基-1,3,4-氧杂双环-2-基）甲酮化合物公开(公告)号：US20120010189A1
公开(公告)日：2012-01-12
申请号：US13176554
申请日：2011-07-05
申请人： Susanne Doris Margit Bökman-Winiwarter , Marlene FREDENWALL , Carl Anders Hogner , Lars Anders Mikael Johansson , Robert Andrew Judkins , Lanna Li , Björn Christian Ingvar Löfberg , Sverker Von Unge
发明人： Susanne Doris Margit Bökman-Winiwarter , Marlene FREDENWALL , Carl Anders Hogner , Lars Anders Mikael Johansson , Robert Andrew Judkins , Lanna Li , Björn Christian Ingvar Löfberg , Sverker Von Unge
IPC分类号： A61K31/4245 , C07D295/155 , A61P3/04 , C07D413/12 , C07D205/04 , C07D413/14 , C07D295/096
CPC分类号： C07D413/06 , A61K31/4245 , C07D413/14
摘要： Disclosed herein are azetidinyl compounds of formula I, as described herein, pharmaceutical compositions comprising an azetidinyl compound, and a method of using an azetidinyl compound in the treatment or prophylaxis of a melanin-concentrating hormone related disease or condition.
摘要翻译： 本文公开的是式I的氮杂环丁烷基化合物，如本文所述，包含氮杂环丁烷基化合物的药物组合物和使用氮杂环丁烷基化合物在治疗或预防黑色素浓缩激素相关疾病或病症中的方法。
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公开(公告)号：US08110566B2
公开(公告)日：2012-02-07
申请号：US12771594
申请日：2010-04-30
申请人： Lars Anders Mikael Johansson , Robert Andrew Judkins , Lanna Li , Bjorn Christian Ingvar Lofberg , Joachim Persson
发明人： Lars Anders Mikael Johansson , Robert Andrew Judkins , Lanna Li , Bjorn Christian Ingvar Lofberg , Joachim Persson
IPC分类号： A61K31/4245 , A61P3/04 , A61P25/22 , A61P25/24 , A61P25/18 , A61P25/28 , C07D491/107
CPC分类号： C07D491/10
摘要： Disclosed herein are compounds of formula I in which R1, R2, R3, R4, R5, A, X, Y are as described in the specification, their use in pharmaceutical compositions and in methods of treatment or prophylaxis of a melanin-concentrating hormone related disease or condition.
摘要翻译： 本文公开的是式I化合物，其中R 1，R 2，R 3，R 4，R 5，A，X，Y如说明书中所述，它们在药物组合物中的用途和治疗或预防黑色素浓缩激素相关的方法 疾病或病症。
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公开(公告)号：US20100280000A1
公开(公告)日：2010-11-04
申请号：US12771594
申请日：2010-04-30
申请人： Lars Anders Mikael JOHANSSON , Robert Andrew Judkins , Lanna Li , Bjorn Christian Ingvar Lofberg , Joachim Persson
发明人： Lars Anders Mikael JOHANSSON , Robert Andrew Judkins , Lanna Li , Bjorn Christian Ingvar Lofberg , Joachim Persson
IPC分类号： A61K31/4245 , C07D491/107 , A61P3/04 , A61P25/22 , A61P25/24 , A61P25/18 , A61P25/28
CPC分类号： C07D491/10
摘要： Disclosed herein are compounds of formula I in which R1, R2, R3, R4, R5, A, X, Y are as described in the specification, their use in pharmaceutical compositions and in methods of treatment or prophylaxis of a melanin-concentrating hormone related disease or condition.
摘要翻译： 本文公开的是式I化合物，其中R 1，R 2，R 3，R 4，R 5，A，X，Y如说明书中所述，它们在药物组合物中的用途和治疗或预防黑色素浓缩激素相关的方法 疾病或病症。
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公开(公告)号：US07488844B2
公开(公告)日：2009-02-10
申请号：US11026806
申请日：2004-12-30
IPC分类号： C07C229/00 , C07C233/12
CPC分类号： C07C233/11 , C07B2200/07 , C07C233/51 , C07C235/20 , C07C235/22 , C07C235/24 , C07C255/46 , C07C309/66 , C07C323/41 , C07C323/56 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/14 , C07D295/135 , C07D295/185
摘要： The present invention provides a compound of formula I processes for preparing such compounds, their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, methods for their therapeutic use and pharmaceutical compositions containing them.
摘要翻译： 本发明提供式I化合物的制备方法，它们可用于治疗包括脂质紊乱（血脂异常）在内的临床症状，不论是否与胰岛素抵抗有关，其治疗用途的方法和含有它们的药物组合物。
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6.发明授权Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance 失效正离子取代的苯甲酸衍生物用于治疗胰岛素抵抗公开(公告)号：US07351858B2
公开(公告)日：2008-04-01
申请号：US10519376
申请日：2003-06-17
申请人： Lanna Li
发明人： Lanna Li
IPC分类号： C07C229/00 , A61K31/195
CPC分类号： C07C235/20
摘要： The present invention provides a compound of formula (I), wherein n is 0, 1 or 2; R1 represents halo, a C1-4alkyl group which is optionally substituted by one or more fluoro, a C1-4alkoxy group which is optionally substituted by one or more fluoro and wherein when n is 2 the substituents R1 may be the same or different; R2 represents an unbranched C2-7alkyl group; R3 represents H or OCH3; and W represents O or S and pharmaceutically acceptable salts and prodrugs thereof, to processes for preparing such compounds, to their utility in treating clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译： 本发明提供式（I）化合物，其中n为0,1或2; R 1表示卤素，任选被一个或多个氟C 1-4烷氧基取代的C 1-4烷基， 其任选被一个或多个氟取代，并且其中当n为2时，取代基R 1可以相同或不同; R 2表示无支链的C 2-7烷基; R 3表示H或OCH 3; W表示O或S及其药学上可接受的盐和前药，用于制备此类化合物的方法，用于治疗与胰岛素抵抗相关的临床病症，其治疗用途的方法和含有它们的药物组合物。
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7.发明申请Guanidine and amidine acid derivatives and analogs and methods of using the same 审中-公开胍和脒酸衍生物及其类似物及使用方法公开(公告)号：US20070149614A1
公开(公告)日：2007-06-28
申请号：US11612706
申请日：2006-12-19
申请人： Krister Bamberg , Lanna Li
发明人： Krister Bamberg , Lanna Li
IPC分类号： A61K31/277 , A61K31/195 , A61K31/165 , C07C279/18
CPC分类号： C07C217/60 , C07C271/28 , C07C279/18 , C07C279/24
摘要： The present invention relates to certain novel guanidine or amidine acid derivatives and analogs, to a process for preparing such compounds, having the utility in clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及某些新颖的胍或脒酸衍生物和类似物，涉及一种制备此类化合物的方法，其具有与胰岛素抵抗相关的临床病症的效用，其治疗用途的方法和含有它们的药物组合物。
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8.发明申请Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance 失效正离子取代的苯甲酸衍生物用于治疗胰岛素抵抗公开(公告)号：US20050222261A1
公开(公告)日：2005-10-06
申请号：US10519376
申请日：2003-06-17
申请人： Lanna Li
发明人： Lanna Li
IPC分类号： A61K20060101 , A61K31/195 , A61P20060101 , C07C20060101 , C07C235/20
CPC分类号： C07C235/20
摘要： The present invention provides a compound of formula (I), wherein n is 0, 1 or 2; R1 represents halo, a C1-4alkyl group which is optionally substituted by one or more fluoro, a C1-4alkoxy group which is optionally substituted by one or more fluoro and wherein when n is 2 the substituents R1 may be the same or different; R2 represents an unbranched C2-7alkyl group; R3 represents H or OCH3; and W represents O or S and pharmaceutically acceptable salts and prodrugs thereof, to processes for preparing such compounds, to their utility in treating clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译： 本发明提供式（I）化合物，其中n为0,1或2; R 1表示卤素，任选被一个或多个氟C 1-4烷氧基取代的C 1-4烷基， 其任选被一个或多个氟取代，并且其中当n为2时，取代基R 1可以相同或不同; R 2表示无支链的C 2-7烷基; R 3表示H或OCH 3; W表示O或S及其药学上可接受的盐和前药，用于制备此类化合物的方法，用于治疗与胰岛素抵抗相关的临床病症，其治疗用途的方法和含有它们的药物组合物。
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公开(公告)号：US06630509B2
公开(公告)日：2003-10-07
申请号：US10148824
申请日：2002-06-03
IPC分类号： A61K3127
CPC分类号： C07C309/66 , C07C43/23 , C07C211/48 , C07C217/64 , C07C233/18 , C07C255/54 , C07C271/28 , C07C317/22 , C07C323/16
摘要： The present invention relates to certain phenalkyloxy-phenyl derivatives of formula (I) and analogs, to a process for preparing such compounds, which compounds have utility in treating clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及一些式（I）的苯氧基 - 苯基衍生物及其类似物，涉及制备这些化合物的方法，该化合物可用于治疗与胰岛素抵抗相关的临床病症，其治疗用途的方法和含有 他们。
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10.发明申请5-Thioxo-1,5-Dihydro-2H-Pyrrol-2-One Derivatives As Liver X Receptor Modulators 审中-公开5-硫代-1,5-二氢-2H-吡咯-2-酮衍生物作为肝X受体调节剂公开(公告)号：US20080255207A1
公开(公告)日：2008-10-16
申请号：US11813467
申请日：2006-01-09
申请人： Patrik Holm , Lanna Li
发明人： Patrik Holm , Lanna Li
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D207/44 , C07D401/06 , C07D403/12 , C07D405/12
摘要： The present invention relates to certain novel compounds of the Formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α(NR1H3) and/or β(NR1H2) and in treating clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的某些新型化合物，用于制备这些化合物，用于调节核激素受体肝X受体（LXR）α（NR1H3）和/或β（NR1H2）和在 治疗包括心血管疾病如动脉粥样硬化的临床病症; 炎性疾病，阿尔茨海默病，与胰岛素抵抗相关的脂质紊乱（血脂异常），2型糖尿病和代谢综合征的其他表现，其治疗用途的方法和含有它们的药物组合物。
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