公开(公告)号：US06333421B1

公开(公告)日：2001-12-25

申请号：US09623598

申请日：2000-09-26

申请人： Susumu Yazawa ,  Tatsuo Watanabe ,  Tohru Fushiki ,  Kenji Kobata ,  Masatake Imai ,  Yuko Setoguchi ,  Shuichi Hashizume

发明人： Susumu Yazawa ,  Tatsuo Watanabe ,  Tohru Fushiki ,  Kenji Kobata ,  Masatake Imai ,  Yuko Setoguchi ,  Shuichi Hashizume

IPC分类号： C07C5700

CPC分类号： A23G1/48 ,  A23L2/56 ,  A23L33/105 ,  C07C69/28 ,  C07C69/533

摘要： The purpose of the invention is to provide capsaicinoid-like substances to be used as food additives and pharmaceutical ingredients. Capsaicinoid-like substances represented by the following general formula: and food and pharmaceutical compositions comprising them.

摘要翻译： 本发明的目的是提供用作食品添加剂和药物成分的类辣椒素样物质。 由以下通式表示的类辣椒素样物质：包含它们的食品和药物组合物。

公开(公告)号：US09340795B2

公开(公告)日：2016-05-17

申请号：US12976526

申请日：2010-12-22

申请人： Hiroaki Kisaka ,  Yaqin Lang ,  Ryuji Sugiyama ,  Tetsuya Miwa ,  Susumu Yazawa

发明人： Hiroaki Kisaka ,  Yaqin Lang ,  Ryuji Sugiyama ,  Tetsuya Miwa ,  Susumu Yazawa

IPC分类号： C12N15/82 ,  C12N15/87 ,  C12P7/62 ,  C12P13/02

CPC分类号： C12N15/8243 ,  C12N15/8218 ,  C12N15/8285 ,  C12P7/62 ,  C12P13/02

摘要： The present invention provides a genetically modified plant that biosynthesizes an increased amount of capsinoids, a method of producing the genetically modified plant, and a production method of capsinoids from the genetically modified plant. More particularly, the present invention provides a genetically modified plant capable of producing capsinoids, which shows a decreased expression or activity of an enzyme that catalyzes an amino group conversion reaction from vanillin to vanillylamine as compared to wild strains, and the like. As a method of suppressing expression or activity of an enzyme, an introduction of DNA encoding an antisense RNA, iRNA, ribozyme or dominant-negative mutant for the target gene, a destruction of the gene by a knockout method, mutagen treatment or transposon insertion, an introduction of a gene encoding an antibody against the enzyme and the like can be mentioned.

摘要翻译： 本发明提供了生物合成增加量的类毒素的遗传修饰植物，生物转基因植物的方法以及来自转基因植物的类毒素的制备方法。 更具体地，本发明提供能够产生辣椒素的遗传修饰植物，与野生株相比，其表现出从香草醛向香草胺催化氨基转化反应的酶的表达或活性降低。 作为抑制酶的表达或活性的方法，引入编码靶基因的反义RNA，iRNA，核酶或显性失活突变体的DNA，通过敲除法，诱变处理或转座子插入破坏基因， 可以提及编码针对酶等的抗体的基因的引入。

公开(公告)号：US20110166371A1

公开(公告)日：2011-07-07

申请号：US12976526

申请日：2010-12-22

申请人： Hiroaki KISAKA ,  Yaqin Lang ,  Ryuji Sugiyama ,  Tetsuya Miwa ,  Susumu Yazawa

发明人： Hiroaki KISAKA ,  Yaqin Lang ,  Ryuji Sugiyama ,  Tetsuya Miwa ,  Susumu Yazawa

IPC分类号： A01H5/00 ,  C12N15/82 ,  C12N15/87 ,  C11B1/00

CPC分类号： C12N15/8243 ,  C12N15/8218 ,  C12N15/8285 ,  C12P7/62 ,  C12P13/02

摘要： The present invention provides a genetically modified plant that biosynthesizes an increased amount of capsinoids, a method of producing the genetically modified plant, and a production method of capsinoids from the genetically modified plant. More particularly, the present invention provides a genetically modified plant capable of producing capsinoids, which shows a decreased expression or activity of an enzyme that catalyzes an amino group conversion reaction from vanillin to vanillylamine as compared to wild strains, and the like. As a method of suppressing expression or activity of an enzyme, an introduction of DNA encoding an antisense RNA, iRNA, ribozyme or dominant-negative mutant for the target gene, a destruction of the gene by a knockout method, mutagen treatment or transposon insertion, an introduction of a gene encoding an antibody against the enzyme and the like can be mentioned.

摘要翻译： 本发明提供了生物合成增加量的类毒素的遗传修饰植物，生物转基因植物的方法以及来自转基因植物的类毒素的制备方法。 更具体地，本发明提供能够产生辣椒素的遗传修饰植物，与野生株相比，其表现出从香草醛向香草胺催化氨基转化反应的酶的表达或活性降低。 作为抑制酶的表达或活性的方法，引入编码靶基因的反义RNA，iRNA，核酶或显性失活突变体的DNA，通过敲除法，诱变处理或转座子插入破坏基因， 可以提及编码针对酶等的抗体的基因的引入。