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1.发明申请公开(公告)号：US20140199370A1
公开(公告)日：2014-07-17
申请号：US13968112
申请日：2013-08-15
IPC分类号： A61K47/48
CPC分类号： A61K47/645 , A61K9/0014 , A61K9/0019 , A61K47/34 , A61K47/40 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/6951 , A61L15/28 , A61L15/44 , A61L26/0023 , A61L26/0066 , A61L2300/252 , A61L2300/258 , A61L2300/622 , A61L2300/626 , A61L2300/802 , B82Y5/00 , C08L5/16
摘要： This application discloses cyclodextrin-modified materials for carrying drugs and other active agents, such as nucleic acids. Compositions are also disclosed of cyclodextrin-modified materials that release such active agents under controlled conditions. The invention also discloses compositions of cyclodextrin-modified polymer carriers that are coupled to biorecognition molecules for assisting the delivery of drugs to their site of action.
摘要翻译： 本申请公开了用于携带药物和其它活性剂如核酸的环糊精改性物质。 还公开了在控制条件下释放这种活性剂的环糊精改性物质的组合物。 本发明还公开了环糊精改性聚合物载体的组合物，其与生物识别分子偶联以辅助将药物递送至其作用位点。
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公开(公告)号：US08277846B2
公开(公告)日：2012-10-02
申请号：US13107024
申请日：2011-05-13
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译： 本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。 该组合物还含有络合剂。 聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。 本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。 颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。 本发明还涉及制备组合物的方法。 该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。 络合剂与聚合物形成包合络合物。 本发明还涉及递送治疗剂的方法。 根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。 还公开了具有下式的化合物：
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公开(公告)号：US07968123B2
公开(公告)日：2011-06-28
申请号：US11588033
申请日：2006-10-25
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译： 本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。 该组合物还含有络合剂。 聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。 本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。 颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。 本发明还涉及制备组合物的方法。 该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。 络合剂与聚合物形成包合络合物。 本发明还涉及递送治疗剂的方法。 根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。 还公开了具有下式的化合物：
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公开(公告)号：US08357377B2
公开(公告)日：2013-01-22
申请号：US10681745
申请日：2003-10-08
IPC分类号： A61K9/00 , A61K39/395 , A61K45/00 , A01N59/00
CPC分类号： A61K47/48969 , A61K9/0014 , A61K9/0019 , A61K47/34 , A61K47/40 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/645 , A61K47/6951 , A61L15/28 , A61L15/44 , A61L26/0023 , A61L26/0066 , A61L2300/252 , A61L2300/258 , A61L2300/622 , A61L2300/626 , A61L2300/802 , B82Y5/00 , C08L5/16
摘要： This application discloses cyclodextrin-modified materials for carrying drugs and other active agents, such as nucleic acids. Compositions are also disclosed of cyclodextrin-modified materials that release such active agents under controlled conditions. The invention also discloses compositions of cyclodextrin-modified polymer carriers that are coupled to biorecognition molecules for assisting the delivery of drugs to their site of action.
摘要翻译： 本申请公开了用于携带药物和其它活性剂如核酸的环糊精改性物质。 还公开了在控制条件下释放这种活性剂的环糊精改性物质的组合物。 本发明还公开了环糊精改性聚合物载体的组合物，其与生物识别分子偶联以辅助将药物递送至其作用位点。
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公开(公告)号：US08092833B2
公开(公告)日：2012-01-10
申请号：US12846344
申请日：2010-07-29
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译： 本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。 该组合物还含有络合剂。 聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。 本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。 颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。 本发明还涉及制备组合物的方法。 该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。 络合剂与聚合物形成包合络合物。 本发明还涉及递送治疗剂的方法。 根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。 还公开了具有下式的化合物：
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公开(公告)号：US20120172525A1
公开(公告)日：2012-07-05
申请号：US13305592
申请日：2011-11-28
CPC分类号： A61K48/0041 , A61K38/44 , A61K47/555 , A61K47/6949 , A61K47/6951 , B82Y5/00 , C08B37/0012 , C08B37/0015 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12N15/87 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译： 本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。 该组合物还含有络合剂。 聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。 本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。 颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。 本发明还涉及制备组合物的方法。 该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。 络合剂与聚合物形成包合络合物。 本发明还涉及递送治疗剂的方法。 根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。 还公开了具有下式的化合物：
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公开(公告)号：US20110182864A1
公开(公告)日：2011-07-28
申请号：US12846344
申请日：2010-07-29
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译： 本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。 该组合物还含有络合剂。 聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。 本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。 颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。 本发明还涉及制备组合物的方法。 该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。 络合剂与聚合物形成包合络合物。 本发明还涉及递送治疗剂的方法。 根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。 还公开了具有下式的化合物：
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公开(公告)号：US07807198B2
公开(公告)日：2010-10-05
申请号：US11321441
申请日：2005-12-28
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译： 本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。 该组合物还含有络合剂。 聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。 本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。 颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。 本发明还涉及制备组合物的方法。 该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。 络合剂与聚合物形成包合络合物。 本发明还涉及递送治疗剂的方法。 根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。 还公开了具有下式的化合物：
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公开(公告)号：US20110256104A1
公开(公告)日：2011-10-20
申请号：US13107024
申请日：2011-05-13
IPC分类号： A61K35/76 , C12N9/96 , C12N7/00 , C12N15/63 , A61K38/14 , A61K31/7088 , A61K31/718 , C07K9/00 , C07K19/00 , C07K14/00 , C08B37/16 , A61P21/00 , A61P35/04 , A61P9/00 , A61P31/12 , A61K38/54
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译： 本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。 该组合物还含有络合剂。 聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。 本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。 颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。 本发明还涉及制备组合物的方法。 该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。 络合剂与聚合物形成包合络合物。 本发明还涉及递送治疗剂的方法。 根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。 还公开了具有下式的化合物：
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公开(公告)号：US20090304798A1
公开(公告)日：2009-12-10
申请号：US12319711
申请日：2009-01-09
IPC分类号： A61K9/14 , A61K31/7088
CPC分类号： A61K9/0043 , A61K9/0073 , A61K9/1272 , A61K9/1635 , A61K9/1647 , A61K9/1652 , A61K48/0008 , C12N15/87
摘要： The present invention provides methods and compositions for attenuating expression of a target gene in vivo. In general, the method includes administering RNAi constructs (such as small-interfering RNAs (i.e., siRNAs) that are targeted to particular mRNA sequences, or nucleic acid material that can produce siRNAs in a cell), in an amount sufficient to attenuate expression of a target gene by an RNA interference mechanism, e.g., in a sequence-dependent, PKR-independent manner. In particular, the subject method can be used to alter the growth, survival or differentiation of cells for therapeutic and cosmetic purposes.
摘要翻译： 本发明提供用于在体内减弱靶基因表达的方法和组合物。 一般来说，该方法包括以足以减弱表达的表达的量施用RNAi构建体（例如靶向特定mRNA序列的小干扰RNA（即siRNA）或可在细胞中产生siRNA的核酸材料） 通过RNA干扰机制的靶基因，例如，依赖于PKR的序列依赖性方式。 特别地，本发明方法可用于改变用于治疗和美容目的的细胞的生长，存活或分化。
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