公开(公告)号：US5464429A

公开(公告)日：1995-11-07

申请号：US114357

申请日：1993-09-01

申请人： Sven-Erik Hedberg ,  Martin Obel ,  Kurt Hoegnelid

发明人： Sven-Erik Hedberg ,  Martin Obel ,  Kurt Hoegnelid

IPC分类号： A61N1/39 ,  A61N1/362

CPC分类号： A61N1/3962

摘要： An apparatus for producing heart defibrillation sequences formed of stimulation pulses and defibrillation shocks contains a unit for delivering pulses through an intracardiac or epicardiac electrode, normally for cardiac pacing, and defibrillator circuitry for delivering defibrillation shocks through defibrillation electrodes. The unit for delivering pacing pulses has an output stage which is capable of generating a stimulation pulse, delivered to the heart via the pacing electrode, having a higher energy content than a pacing pulse, but considerably less energy than a conventional defibrillation shock. A control unit is connected to the unit for delivering stimulation pulses and to the defibrillator circuitry for forming a defibrillation sequence consisting of stimulation pulses and defibrillation shocks. The control unit determines the timing for delivering the stimulation pulses and the defibrillation shocks.

摘要翻译： 用于产生由刺激脉冲和除颤电击形成的心脏除颤序列的装置包含用于通过心脏或心外膜电极（通常用于心脏起搏）输送脉冲的单元，以及用于通过除颤电极输送除颤电击的除颤器电路。 用于输送起搏脉冲的单元具有输出级，其能够产生刺激脉冲，经由起搏电极传递到心脏，具有比起搏脉冲更高的能量含量，但是比传统除颤电击显着更少的能量。 控制单元连接到用于递送刺激脉冲的单元和去纤颤器电路，用于形成由刺激脉冲和除颤电击组成的除颤序列。 控制单元确定输送刺激脉冲和除颤电击的时间。

公开(公告)号：US5662687A

公开(公告)日：1997-09-02

申请号：US407046

申请日：1995-03-17

申请人： Sven-Erik Hedberg ,  Martin Obel ,  Kurt Hoegnelid

发明人： Sven-Erik Hedberg ,  Martin Obel ,  Kurt Hoegnelid

IPC分类号： A61N1/39

CPC分类号： A61N1/3956

摘要： An implantable heart defibrillator includes a pulse generator controlled by a control unit for emitting defibrillation pulses. The pulse generator is controllable to emit a number of low-energy defibrillation pulses, having a lower pulse amplitude and a shorter pulse duration than a conventional defibrillation pulse, with the total energy in the number of low-energy defibrillation pulses being less than the energy in a conventional defibrillation pulse. Each pulse in the number of low-energy defibrillation pulses, however, contains enough energy to depolarize heart cells oriented favorably in relation to the direction of the electrical field of the low-energy defibrillation pulse.

摘要翻译： 可植入心脏除颤器包括由用于发射除颤脉冲的控制单元控制的脉冲发生器。 脉冲发生器是可控制的，以发射多个低能量除颤脉冲，其具有比常规除颤脉冲更低的脉冲幅度和更短的脉冲持续时间，其中低能量除颤脉冲数量的总能量小于能量 在常规除颤脉冲中。 然而，以低能量除颤脉冲数量的每个脉冲包含足够的能量来使相对于低能除颤脉冲的电场方向有利地定向的心脏细胞去极化。

公开(公告)号：US5865838A

公开(公告)日：1999-02-02

申请号：US932653

申请日：1997-09-18

申请人： Martin Obel ,  Sven-Erik Hedberg

发明人： Martin Obel ,  Sven-Erik Hedberg

IPC分类号： A61N1/362 ,  A61N1/39

CPC分类号： A61N1/3925 ,  A61N1/3621 ,  A61N1/3962 ,  A61N1/395

摘要： In an apparatus for terminating atrial fibrillation using pulses having an energy content which is the same as the energy content of conventional pacing pulses, stimulation pulses are respectively emitted by a number of electrodes disposed at different sites in or on a heart experiencing atrial fibrillation. When atrial fibrillation is detected, waveforms are measured at each of the electrodes, and the electrode having the waveform exhibiting the shortest interval between successive identifiable, cyclical waveform characteristics, such as successive P-waves, is selected as a first electrode for beginning an atrial defibrillation attempt. Stimulation pulses are emitted from the first electrode at a stimulation rate which is slightly shorter than the aforementioned shortest interval and the other electrodes are stimulated at a rate which is slightly shorter than the rate for the first electrode. All of the stimulation pulses are delivered starting at the latest local detection point in time. Upon each of the other electrodes reaching a point at which emits a stimulation pulse which coincides with a stimulation pulse emitted by the first electrode, that other electrode is locked to the stimulation rate of the first electrode, until all of the electrodes are stimulating at a coincident rate. Detection is periodically undertaken to determine whether atrial fibrillation has been terminated, and if so the pacemaker resumes its normal pacing operation. If the atrial fibrillation has not been terminated, the procedure is continued (if not yet ended) or repeated.

摘要翻译： 在使用具有与常规起搏脉冲的能量含量相同的能量含量的脉冲终止心房颤动的装置中，刺激脉冲分别由设置在经历心房颤动的心脏中或心脏上的心脏的不同部位的多个电极发射。 当检测到心房颤动时，在每个电极处测量波形，并且选择具有连续的可识别的循环波形特征（例如连续P波）之间具有最短间隔的波形的电极作为用于开始心房的第一电极 除颤尝试 刺激脉冲以比上述最短间隔略短的刺激速率从第一电极发射，并且以比第一电极的速率略短的速率刺激其他电极。 所有的刺激脉冲都是从最新的局部检测点开始的。 在每个其他电极到达发出与第一电极发射的刺激脉冲一致的刺激脉冲的点时，该另一个电极被锁定到第一电极的刺激速率，直到所有电极都被刺激为止 符合率 定期进行检测以确定房颤是否已经终止，如果是，起搏器恢复其正常起搏操作。 如果房颤仍未终止，则继续手术（如尚未结束）或重复。

公开(公告)号：US4757815A

公开(公告)日：1988-07-19

申请号：US942719

申请日：1986-12-17

申请人： Hans Strandberg ,  Sven-Erik Hedberg ,  Martin Obel

发明人： Hans Strandberg ,  Sven-Erik Hedberg ,  Martin Obel

IPC分类号： A61N1/365 ,  A61N1/36

CPC分类号： A61N1/36514

摘要： A heart pacemaker has a pulse generator and circuitry for measuring a respiration signal of the user and a control unit for controlling the pulse generator by changing the pulse repetition rate dependent on the respiration signal. A heart action detector is provided for acquiring heart action signals and the respiration signal measuring circuitry includes detectors for measuring the amplitude fluctuations in the heart action signal and supplying those fluctuations to the control unit.

摘要翻译： 心脏起搏器具有用于测量用户的呼吸信号的脉冲发生器和电路，以及用于通过根据呼吸信号改变脉冲重复率来控制脉冲发生器的控制单元。 提供用于获取心脏动作信号的心脏动作检测器，呼吸信号测量电路包括用于测量心脏动作信号中的振幅波动并将这些波动提供给控制单元的检测器。

公开(公告)号：US5480420A

公开(公告)日：1996-01-02

申请号：US299345

申请日：1994-09-01

申请人： Kurt Hoegnelid ,  Hans Thornander ,  Martin Obel

发明人： Kurt Hoegnelid ,  Hans Thornander ,  Martin Obel

IPC分类号： A61N1/05 ,  A61N1/362 ,  A61N1/04

CPC分类号： A61N1/056

摘要： A temporarily implantable electrode device, intended for sensing electrical signals from living tissue, has an insulating sheath of resorbable material, and at least one non-toxic, liquid conductor contained inside the insulating sheath in order to form an electrical conductor which, via an electrode adapted for interaction with living tissue can sense and carry electrical signals from living tissue to a medical apparatus connected to the electrode device. The resorbable material ultimately dissolves completely into the body of the subject in whom the electrode device was temporarily implanted, and the non-toxic, liquid conductor simultaneously mixes with other fluids, making explantation of the electrode device unnecessary.

摘要翻译： 用于感测来自活体组织的电信号的临时可植入电极装置具有可再吸收材料的绝缘护套，以及包含在绝缘护套内部的至少一种无毒液体导体，以便形成电导体，其经由电极 适于与生物体组织的相互作用可以感测并携带从生物组织到连接到电极装置的医疗装置的电信号。 可再吸收材料最终完全溶解到临时注入电极装置的被检体的体内，并且无毒的液体导体与其它流体同时混合，不需要电极装置的外植。

公开(公告)号：US06748273B1

公开(公告)日：2004-06-08

申请号：US10031548

申请日：2002-06-03

申请人： Martin Obel ,  Niklas Sköldengen ,  Jan Lindberg

发明人： Martin Obel ,  Niklas Sköldengen ,  Jan Lindberg

IPC分类号： A61N137

CPC分类号： G01R31/3662 ,  A61N1/3708

摘要： In a method and an apparatus for detecting the status of a battery in an implantable heart stimulator, the battery impedances measured and an increased value of the measured impedance is detected, from which an impedance based value of the remaining battery capacity is determined. The increase in impedance is analyzed to determine whether the impedance increase is a reliable indicator of the remaining battery capacity. If it is determined that the impedance increase is not reliable for determining the battery capacity, the total charge depletion of the battery is measured and a charge depletion-based value of the remaining battery capacity is determined.

摘要翻译： 在用于检测可植入心脏刺激器中的电池的状态的方法和装置中，检测电池阻抗并检测测量阻抗的增加的值，从而确定剩余电池容量的基于阻抗的值。 分析阻抗的增加以确定阻抗增加是否是剩余电池容量的可靠指标。 如果确定阻抗增加对于确定电池容量是不可靠的，则测量电池的总电荷消耗，并且确定剩余电池容量的基于电荷消耗的值。

公开(公告)号：US5871507A

公开(公告)日：1999-02-16

申请号：US870935

申请日：1997-06-06

申请人： Martin Obel ,  Hans Stranberg ,  Wyn Davies

发明人： Martin Obel ,  Hans Stranberg ,  Wyn Davies

IPC分类号： A61N1/05 ,  A61N1/362 ,  A61N1/365 ,  A61N1/37

CPC分类号： A61N1/3704 ,  A61N1/3622

摘要： A heart stimulator, operable for single-chamber and/or dual-chamber pacing, includes a first unipolar electrical lead placeable in the atrium of a heart, and a second unipolar electrical lead placeable in the ventricle of the heart. In the heart stimulator, a differential detector is connected to each of these unipolar leads and detects a differential signal representative of cardiac activity between the atrial electrode and the ventricular electrode. The differential signal is supplied to decision logic which evaluates each of those outputs including using a morphology analysis, if necessary. Depending on the type of cardiac activity identified as a result of the evaluation, the decision logic supplies a signal to a control unit in the heart stimulator to cause the therapy administered by the heart stimulator to be altered as warranted. The decision logic may also derive a respiration signal from the differential signal, which can also be used to modify the administered therapy.

摘要翻译： 可用于单室和/或双室起搏的心脏刺激器包括可置于心脏心房中的第一单极电引线和可置于心脏心室中的第二单极电引线。 在心脏刺激器中，将差分检测器连接到这些单极引线中的每一个，并检测代表心房电极和心室电极之间的心脏活动的差分信号。 差分信号被提供给决策逻辑，如果需要，评估每个输出，包括使用形态学分析。 根据作为评估结果识别的心脏活动的类型，判定逻辑将信号提供给心脏刺激器中的控制单元，以使心脏刺激器施用的治疗被改变为必要的。 决策逻辑还可以从差分信号导出呼吸信号，其也可以用于修改施用的治疗。

公开(公告)号：US5836984A

公开(公告)日：1998-11-17

申请号：US954688

申请日：1997-10-20

申请人： Martin Obel

发明人： Martin Obel

IPC分类号： A61N1/365 ,  A61N1/37 ,  A61N1/00

CPC分类号： A61N1/3712

摘要： A heart stimulating device for avoiding problems related to fusion beats contains a pulse generator for delivering stimulation pulses to a patient's heart and having a basic escape interval, a detector with a filter which senses QRS characteristics in IEGM signals, a logic stage which controls the pulse generator, and a detector without a filter which senses QRS characteristics in IEGM signals. The logic stage activates the detector without a filter preceding an end of the basic escape interval and prolongs the basic escape interval by a predetermined extension interval if the detector without a filter senses a QRS indication.

摘要翻译： 用于避免与融合搏动有关的问题的心脏刺激装置包含用于将刺激脉冲传送到患者心脏并具有基本逃逸间隔的脉冲发生器，具有感测IEGM信号中的QRS特性的滤波器的检测器，控制脉冲的逻辑级 发生器和不具有感测IEGM信号中QRS特性的滤波器的检测器。 如果没有滤波器的检测器感测到QRS指示，则逻辑级激活检测器，而不需要在基本逃逸间隔结束之前的过滤器，并将基本逃逸间隔延长预定的延伸间隔。

公开(公告)号：US5279293A

公开(公告)日：1994-01-18

申请号：US861150

申请日：1992-03-31

申请人： Hans Andersen ,  Martin Obel ,  Lars Wallen

发明人： Hans Andersen ,  Martin Obel ,  Lars Wallen

IPC分类号： A61N1/39 ,  A61N1/00

CPC分类号： A61N1/3943

摘要： An implantable defibrillator has a capacitor which, through a controllable switch arrangement, can either be connected to a voltage source for charging the capacitor, or connected across electrodes placed at the heart for delivering a defibrillation pulse. To calculate the minimum pulse energy required for successful defibrillation, ventricular fibrillation is first induced, so that a plurality of defibrillation attempts, with energy increasing from attempt-to-attempt can be undertaken until successful defibrillation occurs. For inducing ventricular fibrillation, the capacitor of the implantable defibrillator is connected to the voltage source until a prescribed charging voltage, which is significantly below the voltage necessary for defibrillation, is reached, and subsequently, the capacitor is disconnected from the voltage source during brief time spans at intervals within the framework of a sequence and is connected during those time spans to the electrodes. Between the time spans, the capacitor is again charged.

摘要翻译： 2.1。 已知的可植入除颤器包含电容器，该电容器可以通过可控开关装置连接到电压源，以便再充电，或者连接到置于心脏上的电极，以便发出除颤脉冲。 为了确定除颤的最小所需脉冲能量，首先诱发心室颤动，由此进行多次除颤尝试，每次进行能量增加，直到发生成功的除颤。 2.2。 为了能够通过可植入除颤器以简单的方式诱发心室颤动，电容器（1）连接到电压源（4），直到达到规定的充电电压; 此后，电容器（1）在频率框架内以间隔彼此相对的短时间段内与电压源（4）断开，并连接到电极（10和11）。

公开(公告)号：US20080249375A1

公开(公告)日：2008-10-09

申请号：US11666964

申请日：2004-11-02

申请人： Martin Obel

发明人： Martin Obel

IPC分类号： A61B5/02

CPC分类号： A61N1/08 ,  A61B5/029 ,  A61B5/0452 ,  A61B7/00 ,  A61N1/372

摘要： In a method and an arrangement for evaluating operational effectiveness of an implantable medical device for different lead placements associated with the medical device, a measuring unit records signals that are characteristic of cardiac activity at respectively different lead positions, and these signals are stored. A processor accesses the stored signals and, from the stored signals, determines a measure of cardiac activity at each of the lead positions. The recorded signals may be intracardiac ECG signals, surface ECG signals, heart sound signals obtained from a microphone, or impedance signals. The lead position at which the best hemodynamic behavior of the heart is identified from the analysis of the stored signals, and is determined as being the optimum site for placement of the electrode leads.

摘要翻译： 在用于评估与医疗装置相关联的不同引线布置的可植入医疗装置的操作有效性的方法和装置中，测量单元记录分别在不同引导位置处具有心脏活动特征的信号，并且存储这些信号。 处理器访问所存储的信号，并且从所存储的信号中确定每个引导位置处的心脏活动度量。 记录的信号可以是心内ECG信号，表面ECG信号，从麦克风获得的心音信号或阻抗信号。 从存储的信号的分析中识别心脏的最佳血液动力学行为的引导位置，并且被确定为用于放置电极引线的最佳位置。