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公开(公告)号：US20110307073A1
公开(公告)日：2011-12-15
申请号：US13124161
申请日：2009-10-19
申请人： Swee Hin Teoh , Hae-Ryong Song , Soi Khoon Yew , Kelvin Hong Yap Koh , Ji Hoon Bae , Joon Ho Wang
发明人： Swee Hin Teoh , Hae-Ryong Song , Soi Khoon Yew , Kelvin Hong Yap Koh , Ji Hoon Bae , Joon Ho Wang
CPC分类号： A61F2/28 , A61F2/3094 , A61F2002/30062 , A61F2002/30235 , A61F2002/3024 , A61F2002/3092 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/64 , C08L67/04
摘要： Bioresorbable scaffolds for bone engineering, such as repair of bone defects, particularly long bone defects, or augmentation of bone length are described. Scaffolds are porous and comprise multiple side channels. In one embodiment, scaffolds are made from layers of micro-filament meshes comprising polycaprolactone (PCL) or a PCL-composite sequentially laid in incremental 60 degrees of rotation to produce a 0/60/120 degree layering pattern, providing for the formation of interconnected pores. The scaffold can comprise a central channel filled, packed or infused with suitable agents such as bioactive agents. Furthermore, the scaffolds are stiff but yet fracture resistant and with sufficient bending, compressive and torsional strength suitable for bone engineering. The slow degradation of the scaffold is sufficient for the 3D matrix to maintain structure integrity and mechanical properties during the remodelling process.
摘要翻译： 描述了用于骨工程的生物可再吸收支架，例如修复骨缺损，特别是长骨缺损或增加骨长度。 支架是多孔的并且包括多个侧通道。 在一个实施方案中，支架由包含聚己内酯（PCL）或PCL-复合物的微细丝网层由顺序地以增量60度旋转顺序地铺设以产生0/60/120度分层图案，从而形成互连 毛孔 支架可以包括填充，包装或注入合适试剂如生物活性剂的中心通道。 此外，支架是刚性的但是具有抗断裂性，并且具有适于骨工程的足够的弯曲，压缩和扭转强度。 支架的缓慢降解足以使3D矩阵在重构过程中保持结构完整性和机械性能。
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公开(公告)号：US08702808B2
公开(公告)日：2014-04-22
申请号：US13124161
申请日：2009-10-19
申请人： Swee Hin Teoh , Hae-Ryong Song , Soi Khoon Yew , Kelvin Hong Yap Koh , Ji Hoon Bae , Joon Ho Wang
发明人： Swee Hin Teoh , Hae-Ryong Song , Soi Khoon Yew , Kelvin Hong Yap Koh , Ji Hoon Bae , Joon Ho Wang
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/3094 , A61F2002/30062 , A61F2002/30235 , A61F2002/3024 , A61F2002/3092 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/64 , C08L67/04
摘要： Bioresorbable scaffolds for bone engineering, such as repair of bone defects, particularly long bone defects, or augmentation of bone length are described. Scaffolds are porous and comprise multiple side channels. In one embodiment, scaffolds are made from layers of micro-filament meshes comprising polycaprolactone (PCL) or a PCL-composite sequentially laid in incremental 60 degrees of rotation to produce a 0/60/120 degree layering pattern, providing for the formation of interconnected pores. The scaffold can comprise a central channel filled, packed or infused with suitable agents such as bioactive agents. Furthermore, the scaffolds are stiff but yet fracture resistant and with sufficient bending, compressive and torsional strength suitable for bone engineering. The slow degradation of the scaffold is sufficient for the 3D matrix to maintain structure integrity and mechanical properties during the remodelling process.
摘要翻译： 描述了用于骨工程的生物可再吸收支架，例如修复骨缺损，特别是长骨缺损或增加骨长度。 支架是多孔的并且包括多个侧通道。 在一个实施方案中，支架由包含聚己内酯（PCL）或PCL-复合物的微细丝网层由顺序地以增量60度旋转顺序地铺设以产生0/60/120度分层图案，从而形成互连 毛孔 支架可以包括填充，包装或注入合适试剂如生物活性剂的中心通道。 此外，支架是刚性的但是具有抗断裂性，并且具有适于骨工程的足够的弯曲，压缩和扭转强度。 支架的缓慢降解足以使3D矩阵在重构过程中保持结构完整性和机械性能。
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