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公开(公告)号：US20110159518A1
公开(公告)日：2011-06-30
申请号：US13044289
申请日：2011-03-09
申请人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
发明人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
CPC分类号： C12N9/12 , C07K16/3069 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57449 , Y10S435/975
摘要： The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
摘要翻译： 本发明提供可以在患有卵巢癌的受试者中表达的分离的抗原多肽。 还提供了通过使用本发明的抗原多肽和通过抑制本发明的抗原多肽的基因来预防和/或治疗卵巢癌的卵巢癌的诊断。
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2.发明申请公开(公告)号：US20100111956A1
公开(公告)日：2010-05-06
申请号：US12262085
申请日：2008-10-30
申请人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
发明人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
IPC分类号： A61K39/395 , C07K14/47 , C12N15/12 , C07K16/18 , C12Q1/68 , G01N33/566 , A61P35/00
CPC分类号： C12N9/12 , C07K16/3069 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57449 , Y10S435/975
摘要： The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
摘要翻译： 本发明提供可以在患有卵巢癌的受试者中表达的分离的抗原多肽。 还提供了通过使用本发明的抗原多肽和通过抑制本发明的抗原多肽的基因来预防和/或治疗卵巢癌的卵巢癌的诊断。
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公开(公告)号：US09200262B2
公开(公告)日：2015-12-01
申请号：US13044289
申请日：2011-03-09
申请人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
发明人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
IPC分类号： A61K39/395 , C12N9/12 , C07K16/30 , C12Q1/68 , G01N33/574
CPC分类号： C12N9/12 , C07K16/3069 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57449 , Y10S435/975
摘要： The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
摘要翻译： 本发明提供可以在患有卵巢癌的受试者中表达的分离的抗原多肽。 还提供了通过使用本发明的抗原多肽和通过抑制本发明的抗原多肽的基因来预防和/或治疗卵巢癌的卵巢癌的诊断。
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4.发明授权公开(公告)号：US07928188B2
公开(公告)日：2011-04-19
申请号：US12262085
申请日：2008-10-30
申请人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
发明人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
IPC分类号： C07K7/00
CPC分类号： C12N9/12 , C07K16/3069 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57449 , Y10S435/975
摘要： The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
摘要翻译： 本发明提供可以在患有卵巢癌的受试者中表达的分离的抗原多肽。 还提供了通过使用本发明的抗原多肽和通过抑制本发明的抗原多肽的基因来预防和/或治疗卵巢癌的卵巢癌的诊断。
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5.发明授权Anti-α-enolase I antibodies for diagnosis and treatment of α-enolase I-associated diseases 有权用于诊断和治疗α-烯醇酶I相关疾病的抗α-烯醇酶I抗体公开(公告)号：US08449881B2
公开(公告)日：2013-05-28
申请号：US12695627
申请日：2010-01-28
申请人： Sy-Jye Leu , Yi-Yuan Yang , Neng-Yao Shih , I-Jen Huang , Ko-Jiunn Liu , Yu-Ching Lee , Yung-Leun Shih , Yu-Jia Chang , Bor-Yu Tsai , Yuan-Soon Ho
发明人： Sy-Jye Leu , Yi-Yuan Yang , Neng-Yao Shih , I-Jen Huang , Ko-Jiunn Liu , Yu-Ching Lee , Yung-Leun Shih , Yu-Jia Chang , Bor-Yu Tsai , Yuan-Soon Ho
IPC分类号： A61K39/395
CPC分类号： C07K16/40 , C07K2317/11 , C07K2317/23 , C07K2317/622 , G01N33/573
摘要： The invention relates to antibodies against α-enolase I, their pharmaceutical compositions and diagnosis and treatment uses. Particularly, the invention provides polyclonal anti-α-enolase I antibodies and monoclonal single-chain variable fragment (scFv) anti-α-enolase antibodies, pharmaceutical compositions containing the same and their uses in uses in diagnosis and treatment of cancers, autoimmune disorders, ischemia and bacterial infection.
摘要翻译： 本发明涉及抗α-烯醇酶I的抗体，其药物组合物和诊断和治疗用途。 特别地，本发明提供了多克隆抗-α-烯醇化酶I抗体和单克隆单链可变片段（scFv）抗-α-烯醇化酶抗体，含有该抗体的药物组合物及其用于诊断和治疗癌症，自身免疫疾病， 缺血和细菌感染。
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6.发明申请Anti-alpha-Enolase I Antibodies for Diagnosis and Treatment of alpha-Enolase I-Associated Diseases 有权用于诊断和治疗α-烯醇酶I相关疾病的抗α-烯醇酶I抗体公开(公告)号：US20110182907A1
公开(公告)日：2011-07-28
申请号：US12695627
申请日：2010-01-28
申请人： Sy-Jye Leu , Yi-Yuan Yang , Neng-Yao Shih , I-Jen Huang , Ko-Jiunn Liu , Yu-Ching Lee , Yung-Leun Shih , Yu-Jia Chang , Bor-Yu Tsai , Yuan-Soon Ho
发明人： Sy-Jye Leu , Yi-Yuan Yang , Neng-Yao Shih , I-Jen Huang , Ko-Jiunn Liu , Yu-Ching Lee , Yung-Leun Shih , Yu-Jia Chang , Bor-Yu Tsai , Yuan-Soon Ho
IPC分类号： A61K39/395 , C07K16/18 , G01N33/573 , A61P35/00
CPC分类号： C07K16/40 , C07K2317/11 , C07K2317/23 , C07K2317/622 , G01N33/573
摘要： The invention relates to antibodies against α-enolase I, their pharmaceutical compositions and diagnosis and treatment uses. Particularly, the invention provides polyclonal anti-α-enolase I antibodies and monoclonal single-chain variable fragment (scFv) anti-α-enolase antibodies, pharmaceutical compositions containing the same and their uses in uses in diagnosis and treatment of cancers, autoimmune disorders, ischemia and bacterial infection.
摘要翻译： 本发明涉及抗α-烯醇酶I的抗体，其药物组合物和诊断和治疗用途。 特别地，本发明提供了多克隆抗α-烯醇酶I抗体和单克隆单链可变片段（scFv）抗α-烯醇酶抗体，含有该抗体的α-烯醇化酶抗体，其用于诊断和治疗癌症，自身免疫疾病， 缺血和细菌感染。
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7.发明授权Use of outer membrane protein A (OMPA) in treatment/prevention/diagnosis of infections caused by Klebsiella pneumoniae and other gram-negative bacteria 有权使用外膜蛋白A（OMPA）治疗/预防/诊断由肺炎克雷伯杆菌和其他革兰氏阴性细菌引起的感染公开(公告)号：US07807139B2
公开(公告)日：2010-10-05
申请号：US12359205
申请日：2009-01-23
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K49/00 , A61K39/00 , A61K39/108
CPC分类号： G01N33/56916 , A61K38/164 , A61K39/025 , G01N2469/10 , Y02A50/474 , Y02A50/482 , Y02A50/484
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
摘要翻译： 本发明提供一种通过施用有效量的外膜蛋白A（OmpA）来治疗和/或预防哺乳动物的中枢神经系统和/或外周血循环中由肺炎克雷伯杆菌和其它革兰氏阴性细菌引起的细菌感染的方法 ）或其衍生物。 还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或 哺乳动物的外周血循环。
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8.发明申请公开(公告)号：US20100087373A1
公开(公告)日：2010-04-08
申请号：US12569363
申请日：2009-09-29
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
CPC分类号： A61K38/164 , C07K16/1232 , C07K2317/11 , C07K2317/23 , C07K2317/76 , G01N33/56916 , G01N33/6893 , G01N2800/26
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
摘要翻译： 本发明提供了一种通过将有效量的外膜蛋白A（OmpA）或其衍生物施用于哺乳动物的中枢神经系统和/或外周血循环中由肠杆菌科细菌引起的细菌感染的治疗和/或预防方法 哺乳动物。 还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或 哺乳动物的外周血循环。 还提供了基于疫苗接种方法和检测/诊断方法的抗体和试剂盒。
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9.发明申请USE OF OUTER MEMBRANE PROTEIN A (OMPA) IN TREATMENT/PREVENTION/DIAGNOSIS OF INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE AND OTHER GRAM-NEGATIVE BACTERIA 有权使用外膜蛋白A（OMPA）治疗/预防/诊断由克氏杆菌肺炎和其他灰质细菌引起的感染公开(公告)号：US20090232852A1
公开(公告)日：2009-09-17
申请号：US12359205
申请日：2009-01-23
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K39/108 , A61K38/16 , A61K39/02 , G01N33/569 , A61K39/112
CPC分类号： G01N33/56916 , A61K38/164 , A61K39/025 , G01N2469/10 , Y02A50/474 , Y02A50/482 , Y02A50/484
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
摘要翻译： 本发明提供了一种通过施用有效量的外膜蛋白A（OmpA）来治疗和/或预防哺乳动物中枢神经系统和/或外周血循环中由肺炎克雷伯杆菌和其它革兰氏阴性细菌引起的细菌感染的方法 ）或其衍生物。 还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或 哺乳动物的外周血循环。
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10.发明授权公开(公告)号：US08361441B2
公开(公告)日：2013-01-29
申请号：US12569363
申请日：2009-09-29
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K49/00 , A61K39/02 , A61K39/112
CPC分类号： A61K38/164 , C07K16/1232 , C07K2317/11 , C07K2317/23 , C07K2317/76 , G01N33/56916 , G01N33/6893 , G01N2800/26
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
摘要翻译： 本发明提供了一种通过将有效量的外膜蛋白A（OmpA）或其衍生物施用于哺乳动物的中枢神经系统和/或外周血循环中由肠杆菌科细菌引起的细菌感染的治疗和/或预防方法 哺乳动物。 还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或 哺乳动物的外周血循环。 还提供了基于疫苗接种方法和检测/诊断方法的抗体和试剂盒。
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