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公开(公告)号：US10328044B2
公开(公告)日：2019-06-25
申请号：US16220766
申请日：2018-12-14
申请人： SynAgile Corporation
发明人： Adam Heller
IPC分类号： A61K31/195 , A61K31/198 , A61K9/00 , A61K9/10 , A61J7/00 , A61K9/06 , A61K9/14 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/34 , A61M31/00 , A61C19/06 , A61M11/00 , B81B7/02 , A61C7/08
摘要： The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
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公开(公告)号：US09901561B2
公开(公告)日：2018-02-27
申请号：US15448208
申请日：2017-03-02
申请人： SynAgile Corporation
IPC分类号： A61K31/195 , A61K31/198 , A61J7/00 , A61K9/14 , A61K9/06 , A61K47/02 , A61K9/00 , A61K9/10 , A61K47/12 , A61K47/34 , A61K47/18
CPC分类号： A61K31/198 , A61J7/0076 , A61K9/0053 , A61K9/06 , A61K9/10 , A61K9/14 , A61K31/195 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/34 , A61M31/002
摘要： The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
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公开(公告)号：US10588882B2
公开(公告)日：2020-03-17
申请号：US16436468
申请日：2019-06-10
申请人： SynAgile Corporation
发明人： Adam Heller , John Spiridigliozzi
IPC分类号： A61K31/195 , A61K31/198 , A61K9/00 , A61K9/10 , A61M31/00 , A61C19/06 , A61M11/00 , A61J7/00 , A61K9/06 , A61K9/14 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/34 , B81B7/02 , A61C7/08
摘要： The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
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公开(公告)号：US10300033B2
公开(公告)日：2019-05-28
申请号：US15887243
申请日：2018-02-02
申请人： SynAgile Corporation
发明人： Adam Heller
IPC分类号： A61K31/195 , A61K31/198 , A61J7/00 , A61K9/00 , A61K9/06 , A61K9/10 , A61M31/00 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/34 , A61K9/14
摘要： The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
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公开(公告)号：US20150217046A1
公开(公告)日：2015-08-06
申请号：US14405633
申请日：2013-06-04
申请人： SynAgile Corporation
发明人： Adam Heller , Ephraim Heller
IPC分类号： A61M5/142 , A61K31/165 , A61K31/198 , A61K38/47 , A61K31/325
CPC分类号： A61M5/14248 , A61K9/0019 , A61K31/165 , A61K31/198 , A61K31/216 , A61K31/325 , A61K38/47 , A61M5/14244 , A61M5/1723 , A61M2230/005 , A61M2230/63 , C12Y302/01035
摘要： The invention features methods, compositions, dosing regimens, and infusion pumps for subcutaneously infusing acidic solutions of L-DOPA prodrugs, such as esters and amides of L-DOPA, for the treatment of Parkinson's disease. The methods and acidic compositions of the invention can reduce the severity and rate of occurrence of transient local swelling, erythema, and persistent subcutaneous granulomas associated with subcutaneous delivery of certain agents used in the treatment of Parkinson's disease.
摘要翻译： 本发明的特征在于用于皮下注射L-DOPA前药的酸性溶液如L-DOPA的酯和酰胺的方法，组合物，给药方案和输注泵用于治疗帕金森病。 本发明的方法和酸性组合物可以降低与用于治疗帕金森病的某些药物皮下递送相关的瞬时局部肿胀，红斑和持续皮下肉芽肿的严重性和发生率。
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公开(公告)号：US11426376B2
公开(公告)日：2022-08-30
申请号：US17480860
申请日：2021-09-21
申请人： SynAgile Corporation
IPC分类号： A61K31/195 , A61K9/00 , A61K31/198 , A61K9/10 , A61M31/00 , A61C19/06 , A61M11/00 , A61K47/18 , A61J7/00 , A61K9/06 , A61K9/14 , A61K47/02 , A61K47/12 , A61K47/34 , B81B7/02 , A61C7/08
摘要： The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
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公开(公告)号：US11135191B2
公开(公告)日：2021-10-05
申请号：US17031243
申请日：2020-09-24
申请人： SynAgile Corporation
IPC分类号： A61K31/195 , A61K9/10 , A61K31/198 , A61K9/00 , A61M31/00 , A61C19/06 , A61M11/00 , A61K47/18 , A61J7/00 , A61K9/06 , A61K9/14 , A61K47/02 , A61K47/12 , A61K47/34 , B81B7/02 , A61C7/08
摘要： The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
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公开(公告)号：US10786474B2
公开(公告)日：2020-09-29
申请号：US16818435
申请日：2020-03-13
申请人： SynAgile Corporation
发明人： Adam Heller , John Spiridigliozzi
IPC分类号： A61K31/195 , A61K31/198 , A61K47/34 , A61K47/18 , A61K47/12 , A61K47/02 , A61K9/14 , A61K9/06 , A61J7/00 , A61K9/00 , A61M11/00 , A61C19/06 , A61M31/00 , A61K9/10 , B81B7/02 , A61C7/08
摘要： The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
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