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30 条记录 (耗时 0.021 秒)

    Diaza-spiropiperidine derivatives
    2.
    发明授权
    Diaza-spiropiperidine derivatives 失效
    二氮杂 - 哌啶衍生物

    公开(公告)号：US07173133B2

    公开(公告)日：2007-02-06

    申请号：US11028281

    申请日：2005-01-03

    申请人： Simona Maria Ceccarelli ,  Synese Jolidon ,  Emmanuel Pinard ,  Andrew William Thomas

    发明人： Simona Maria Ceccarelli ,  Synese Jolidon ,  Emmanuel Pinard ,  Andrew William Thomas

    IPC分类号： C07D471/10 ,  C07D405/14

    CPC分类号： C07D471/10

    摘要： The present invention relates to compounds of formula wherein A-B is —CH2—CH2—, —CH2—O— or —O—CH2—; X is hydrogen or hydroxy; R1 is aryl, optionally substituted by one or two substituents selected from the group consisting of halogen, lower alkyl, cyano, CF3, —OCF3, lower alkoxy, —SO2-lower alkyl and heteroaryl; R2 is aryl, optionally substituted by one or two substituents selected from the group consisting of halogen, lower alkyl, CF3, and lower alkoxy; R3 is hydrogen or lower alkyl; n is 0, 1 or 2; or a pharmaceutically active salt thereof. The compounds of the invention may be used in the treatment of neurological and neuropsychiatric disorders.

    摘要翻译： 本发明涉及下式的化合物其中AB是-CH 2 -CH 2 - ， - CH 2 -O - 或-O- CH 2 - ; X是氢或羟基; R 1是芳基，任选被一个或两个选自卤素，低级烷基，氰基，CF 3，-OCF 3， 低级烷氧基，-SO 2 - 低级烷基和杂芳基; R 2是任选被一个或两个选自卤素，低级烷基，CF 3 N 3和低级烷氧基的取代基取代的芳基; R 3是氢或低级烷基; n为0,1或2; 或其药物活性盐。 本发明的化合物可用于治疗神经和神经精神障碍。

    Bicyclic compounds
    3.
    发明授权
    Bicyclic compounds 失效
    双环化合物

    公开(公告)号：US07173023B2

    公开(公告)日：2007-02-06

    申请号：US10967567

    申请日：2004-10-18

    申请人： Synese Jolidon ,  Rosa Maria Rodriguez Sarmiento ,  Andrew William Thomas ,  Wolfgang Wostl ,  Rene Wyler

    发明人： Synese Jolidon ,  Rosa Maria Rodriguez Sarmiento ,  Andrew William Thomas ,  Wolfgang Wostl ,  Rene Wyler

    IPC分类号： A61K31/55 ,  C07D223/16 ,  C07D487/02

    CPC分类号： C07D223/16

    摘要： The present invention relates to novel benzazepine derivatives of the following formula: wherein R1, R2, R3, R4 and R5, X, X′, Y and Y′ are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.

    摘要翻译： 本发明涉及下式的新型苯并氮杂衍生物：其中R 1，R 2，R 3，R 4， / SUP>和R 5，X，X'，Y和Y'如说明书和权利要求书中所定义，其制备方法，含有所述衍生物的药物组合物及其用于制备药物的用途 可用于预防和治疗单胺氧化酶B活性的选择性抑制发挥作用或牵连的疾病。