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公开(公告)号:US07122562B2
公开(公告)日:2006-10-17
申请号:US11325747
申请日:2006-01-05
申请人: Hans Iding , Synese Jolidon , Daniela Krummenacher , Rosa Maria Rodriguez-Sarmiento , Andrew William Thomas , Beat Wirz , Wolfgang Wostl , Rene Wyler
发明人: Hans Iding , Synese Jolidon , Daniela Krummenacher , Rosa Maria Rodriguez-Sarmiento , Andrew William Thomas , Beat Wirz , Wolfgang Wostl , Rene Wyler
IPC分类号: A61K31/4439 , C07D401/04
CPC分类号: C07D207/273 , C07D207/277
摘要: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
摘要翻译: 本发明涉及外消旋或对映体纯的4-吡咯烷子基衍生物,其制备方法,包含所述衍生物的药物组合物及其在预防和治疗疾病中的用途,特别是其由单胺氧化酶B抑制剂介导的,特别是阿尔茨海默氏病 或老年痴呆症。
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公开(公告)号:US07253318B2
公开(公告)日:2007-08-07
申请号:US11156417
申请日:2005-06-20
申请人: Synese Jolidon , Rosa Maria Rodriguez-Sarmiento , Andrew William Thomas , Wolfgang Wostl , Rene Wyler
发明人: Synese Jolidon , Rosa Maria Rodriguez-Sarmiento , Andrew William Thomas , Wolfgang Wostl , Rene Wyler
IPC分类号: C07C233/65 , A61K31/165
CPC分类号: C07C255/54 , C07C235/20
摘要: The invention relates to compounds of the formula and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, n, m, and o are as defined in the specification. The compounds are selective monoamine oxidase β inhibitors and are useful for the treatment and prevention of Alzheimer's disease and senile dementia, as well as other CNS disorders. The invention also relates to processes for preparing such compounds and pharmaceutical compositions containing them.
摘要翻译: 本发明涉及下式的化合物及其药学上可接受的盐,其中R 1,R 2,R 3,R 4, / SUP>,R 5,n,m和o如说明书中所定义。 这些化合物是选择性单胺氧化酶β抑制剂,并且可用于治疗和预防阿尔茨海默氏病和老年痴呆以及其它CNS疾病。 本发明还涉及制备这些化合物的方法和含有它们的药物组合物。
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公开(公告)号:US06846832B2
公开(公告)日:2005-01-25
申请号:US10625116
申请日:2003-07-22
IPC分类号: A61K31/4035 , A61K31/405 , A61P1/14 , A61P3/00 , A61P3/04 , A61P25/00 , A61P25/02 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/34 , A61P43/00 , C07D209/46 , C07D209/48 , C07D471/04 , A61K31/435 , C07D209/44 , C07D221/02
CPC分类号: C07D471/04 , C07D209/46
摘要: 2,3-Dihydro-isoindol-1-one derivatives, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them, for the prevention and treatment of diseases which are mediated by monoamine oxidase B.
摘要翻译: 2,3-二氢 - 异吲哚-1-酮衍生物,其制备方法,它们作为药物的用途和包含它们的药物组合物,用于预防和治疗由单胺氧化酶B介导的疾病。
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公开(公告)号:US07235581B2
公开(公告)日:2007-06-26
申请号:US10666594
申请日:2003-09-18
申请人: Synese Jolidon , Rosa Maria Rodriguez-Sarmiento , Andrew William Thomas , Wolfgang Wostl , Rene Wyler
发明人: Synese Jolidon , Rosa Maria Rodriguez-Sarmiento , Andrew William Thomas , Wolfgang Wostl , Rene Wyler
IPC分类号: A61K31/4015 , C07D207/04
CPC分类号: C07D207/273 , C07D207/277
摘要: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, e.g. which are mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
摘要翻译: 本发明涉及外消旋或对映体纯的4-吡咯烷子基衍生物,其制备方法,包含所述衍生物的药物组合物及其在预防和治疗疾病中的用途。 其由单胺氧化酶B抑制剂介导,特别是阿尔茨海默病或老年痴呆。
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公开(公告)号:US07037935B2
公开(公告)日:2006-05-02
申请号:US10667088
申请日:2003-09-18
申请人: Hans Iding , Synese Jolidon , Daniela Krummenacher , Rosa Maria Rodriguez-Sarmiento , Andrew William Thomas , Beat Wirz , Wolfgang Wostl , Rene Wyler
发明人: Hans Iding , Synese Jolidon , Daniela Krummenacher , Rosa Maria Rodriguez-Sarmiento , Andrew William Thomas , Beat Wirz , Wolfgang Wostl , Rene Wyler
IPC分类号: A61K31/402 , C07D209/34
CPC分类号: C07D207/273 , C07D207/277
摘要: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
摘要翻译: 本发明涉及外消旋或对映体纯的4-吡咯烷子基衍生物,其制备方法,包含所述衍生物的药物组合物及其在预防和治疗疾病中的用途,特别是其由单胺氧化酶B抑制剂介导的,特别是阿尔茨海默氏病 或老年痴呆症。
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公开(公告)号:US07151111B2
公开(公告)日:2006-12-19
申请号:US10667087
申请日:2003-09-18
申请人: Hans Iding , Synese Jolidon , Daniela Krummenacher , Rosa Maria Rodriguez-Sarmiento , Andrew William Thomas , Beat Wirz , Wolfgang Wostl , Rene Wyler
发明人: Hans Iding , Synese Jolidon , Daniela Krummenacher , Rosa Maria Rodriguez-Sarmiento , Andrew William Thomas , Beat Wirz , Wolfgang Wostl , Rene Wyler
IPC分类号: A61K31/44 , A61K31/40 , C07D401/06 , C07D207/06
CPC分类号: C07D207/273 , C07D207/277
摘要: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of a disease which is mediated by a monoamine oxidase B inhibitor, in particular Alzheimer's disease and senile dementia.
摘要翻译: 本发明涉及外消旋或对映体纯的4-吡咯烷子基衍生物,其制备方法,包含所述衍生物的药物组合物及其在预防和治疗由单胺氧化酶B抑制剂,特别是阿尔茨海默氏病介导的疾病中的用途,以及 老年性痴呆。
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公开(公告)号:US07456210B2
公开(公告)日:2008-11-25
申请号:US11190626
申请日:2005-07-27
IPC分类号: A61K31/4015 , C07D207/12
CPC分类号: C07D207/26 , C07D207/277 , C07D403/04 , C07D413/04 , C07D417/04
摘要: The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the specification and to pharmaceutically acceptable salts thereof for the treatment of diseases, which are mediated by monoamine oxidase B inhibitors, for example Alzheimer's disease and senile dementia.
摘要翻译: 本发明涉及式I化合物,其中R 1和R 2定义如本说明书及其药学上可接受的盐,用于治疗疾病,其是介导的 通过单胺氧化酶B抑制剂,例如阿尔茨海默病和老年痴呆。
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公开(公告)号:US20110183979A1
公开(公告)日:2011-07-28
申请号:US13005572
申请日:2011-01-13
申请人: Konrad Bleicher , Alexander Flohr , Katrin Groebke Zbinden , Matthias Koerner , Bernd Kuhn , Jens-Uwe Peters , Rosa Maria Rodriguez-Sarmiento , Eric Vieira
发明人: Konrad Bleicher , Alexander Flohr , Katrin Groebke Zbinden , Matthias Koerner , Bernd Kuhn , Jens-Uwe Peters , Rosa Maria Rodriguez-Sarmiento , Eric Vieira
IPC分类号: A61K31/506 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/497 , A61P25/18 , A61P25/22 , A61P25/00 , A61P25/16 , A61P25/28 , A61P25/24 , A61P7/00 , A61P35/00 , A61P3/10
CPC分类号: C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要: The invention is concerned with novel nitrogen-containing heteroaryl derivatives of formula (I) wherein R1, R2, R3, R4, R5, A1, A2, and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型含氮杂芳基衍生物,其中R1,R2,R3,R4,R5,A1,A2和Y如说明书和权利要求书中所定义,以及生理上可接受的盐 及其酯。 这些化合物抑制PDE10A,并可用作药物。
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公开(公告)号:US07754736B2
公开(公告)日:2010-07-13
申请号:US12246547
申请日:2008-10-07
申请人: Matthias Heinrich Nettekoven , Jean-Marc Plancher , Olivier Roche , Rosa Maria Rodriguez-Sarmiento
发明人: Matthias Heinrich Nettekoven , Jean-Marc Plancher , Olivier Roche , Rosa Maria Rodriguez-Sarmiento
IPC分类号: A61K31/4468
CPC分类号: C07D401/14 , C07D401/12
摘要: The present invention relates to compounds of formula I wherein R1, R2, R3, R4 and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译: 本发明涉及式I化合物,其中R 1,R 2,R 3,R 4和m如说明书和权利要求及其药学上可接受的盐以及包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号:US20090042903A1
公开(公告)日:2009-02-12
申请号:US12246523
申请日:2008-10-07
IPC分类号: A61K31/496 , C07D401/04 , A61P3/04
CPC分类号: C07D213/74 , C07D213/75 , C07D213/76
摘要: The present invention relates to compounds of formula I wherein R1, R2, X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译: 本发明涉及式I化合物,其中R 1,R 2,X,Y,Z和m如说明书和权利要求书中所定义,及其药学上可接受的盐以及包含这些化合物的药物组合物及其制备方法 。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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