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    NOVEL PHOSPHINE LIGANDS
    1.
    发明申请
    NOVEL PHOSPHINE LIGANDS 审中-公开
    新的磷酸盐配体

    公开(公告)号：US20090326253A1

    公开(公告)日：2009-12-31

    申请号：US12557553

    申请日：2009-09-11

    申请人： Hans Iding ,  Ernst Kupfer ,  Bruno Lohri ,  Kazimierz Michal Pietrusiewicz ,  Kurt Puentener ,  Michelangelo Scalone ,  Wioleta Swierczynska ,  Beat Wirz

    发明人： Hans Iding ,  Ernst Kupfer ,  Bruno Lohri ,  Kazimierz Michal Pietrusiewicz ,  Kurt Puentener ,  Michelangelo Scalone ,  Wioleta Swierczynska ,  Beat Wirz

    IPC分类号： C07F15/04

    CPC分类号： C07F15/006 ,  C07B53/00 ,  C07F9/65683 ,  C07F15/0066

    摘要： The invention is concerned with new phosphine ligands of the formula I whereinR1 and R2 are independently of each other alkyl, aryl, cycloalkyl or heteroaryl, said alkyl, aryl, cycloalkyl or heteroaryl may be substituted by alkyl, alkoxy, halogen, hydroxy, amino, mono- or dialkylamino, aryl, —SO2—R7, —SO3−, —CO—NR8R8′, carboxy, alkoxycarbonyl, trialkylsilyl, diarylalkylsilyl, dialkylarylsilyl or triarylsilyl;R3 is alkyl, cycloalkyl, aryl or heteroaryl; R4′ and R4 signify independently of each other hydrogen, alkyl or optionally substituted aryl; or R4′ and R4 together with the C-atom they are attached to form a 3-8-membered carbocyclic ring; dotted line is absent or is present and forms a double bond; R5 and R6 are independently of each other hydrogen, alkyl or aryl; or linked together to form a 3-8-membered carbocyclic ring or an aromatic ring; R7 is alkyl, aryl or NR8R8′; and R8 and R8′ are independently of each other hydrogen, alkyl or aryl;metal complexes with such ligands as well as the use of such metal complexes as catalysts in asymmetric reactions.

    摘要翻译： 本发明涉及式I的新膦配体，其中R 1和R 2彼此独立地为烷基，芳基，环烷基或杂芳基，所述烷基，芳基，环烷基或杂芳基可以被烷基，烷氧基，卤素，羟基，氨基 ，一或二烷基氨基，芳基，-SO 2 -R 7，-SO 3 - ，-CO-NR 8 R 8'，羧基，烷氧基羰基，三烷基甲硅烷基，二芳基烷基甲硅烷基，二烷基芳基甲硅烷基或三芳基甲硅烷基; R3是烷基，环烷基，芳基或杂芳基; R4'和R4独立地表示氢，烷基或任选取代的芳基; 或R 4'和R 4与它们所连接的C原子一起形成3-8-元碳环; 虚线不存在或存在并形成双键; R5和R6彼此独立地为氢，烷基或芳基; 或连接在一起形成3-8元碳环或芳环; R7是烷基，芳基或NR8R8'; R8和R8'彼此独立地为氢，烷基或芳基; 与这种配体的金属络合物以及在不对称反应中使用这样的金属络合物作为催化剂。

    Novel phosphine ligands
    3.
    发明申请
    Novel phosphine ligands 失效
    新型膦配体

    公开(公告)号：US20070100152A1

    公开(公告)日：2007-05-03

    申请号：US11591277

    申请日：2006-11-01

    申请人： Hans Iding ,  Ernst Kupfer ,  Bruno Lohri ,  Kazimierz Pietrusiewicz ,  Kurt Puentener ,  Michelangelo Scalone ,  Wioleta Swierczynska ,  Beat Wirz

    发明人： Hans Iding ,  Ernst Kupfer ,  Bruno Lohri ,  Kazimierz Pietrusiewicz ,  Kurt Puentener ,  Michelangelo Scalone ,  Wioleta Swierczynska ,  Beat Wirz

    IPC分类号： C07F15/04 ,  C07F9/02

    CPC分类号： C07F15/006 ,  C07B53/00 ,  C07F9/65683 ,  C07F15/0066

    摘要： The invention is concerned with new phosphine ligands of the formula I wherein R1 and R2 are independently of each other alkyl, aryl, cycloalkyl or heteroaryl, said alkyl, aryl, cycloalkyl or heteroaryl may be substituted by alkyl, alkoxy, halogen, hydroxy, amino, mono- or dialkylamino, aryl, —SO2—R7, —SO3−, —CO—NR8R8′, carboxy, alkoxycarbonyl, trialkylsilyl, diarylalkylsilyl, dialkylarylsilyl or triarylsilyl; R3 is alkyl, cycloalkyl, aryl or heteroaryl; R4′ and R4 signify independently of each other hydrogen, alkyl or optionally substituted aryl; or R4′ and R4 together with the C-atom they are attached to form a 3-8-membered carbocyclic ring; dotted line is absent or is present and forms a double bond; R5 and R6 are independently of each other hydrogen, alkyl or aryl; or linked together to form a 3-8-membered carbocyclic ring or an aromatic ring; R7 is alkyl, aryl or NR8R8′; and R8 and R8′ are independently of each other hydrogen, alkyl or aryl; metal complexes with such ligands as well as the use of such metal complexes as catalysts in asymmetric reactions.

    摘要翻译： 本发明涉及式I的新膦配体，其中R 1和R 2彼此独立地为烷基，芳基，环烷基或杂芳基，所述烷基，芳基， 环烷基或杂芳基可以被烷基，烷氧基，卤素，羟基，氨基，一或二烷基氨基，芳基，-SO 2 -R 7，-SO 3， 羧基，烷氧基羰基，三烷基甲硅烷基，二芳基烷基甲硅烷基，二烷基芳基甲硅烷基或三芳基甲硅烷基;取代或未取代的苯基， R 3是烷基，环烷基，芳基或杂芳基; R 4'和R 4'彼此独立地表示氢，烷基或任选取代的芳基; 或R 4'和R 4与它们连接的C原子一起形成3-8元碳环; 虚线不存在或存在并形成双键; R 5和R 6彼此独立地为氢，烷基或芳基; 或连接在一起形成3-8元碳环或芳环; R 7是烷基，芳基或NR 8 R 8; R 8和R 8'彼此独立地为氢，烷基或芳基; 与这种配体的金属络合物以及在不对称反应中使用这样的金属络合物作为催化剂。

    Enzymatic acylation
    5.
    发明授权
    Enzymatic acylation 失效
    酶酰化

    公开(公告)号：US5902738A

    公开(公告)日：1999-05-11

    申请号：US829280

    申请日：1997-03-31

    申请人： Bernard Orsat ,  Paul Spurr ,  Beat Wirz

    发明人： Bernard Orsat ,  Paul Spurr ,  Beat Wirz

    IPC分类号： C12N9/20 ,  C07C35/18 ,  C12P7/40 ,  C12P7/62 ,  C12P7/64 ,  C12P23/00 ,  C12P7/02 ,  C07C67/02 ,  C12N11/02

    CPC分类号： C12P7/62 ,  C12P23/00

    摘要： A process for making a compound of formula ##STR1## wherein R signifies a C.sub.1-23 -alkyl group or a C.sub.2-23 -alkenyl group containing 1 to 3 double bonds, comprising the steps of (a) reacting a compound of formula ##STR2## with an acylating agent which is in a mixture comprising (i) an organic solvent and (ii) a lipase which is present in suspension, so as to form the compound of formula I; and (b) recovering the compound of formula I is provided for. The process can be used to make (11Z,13Z)-7,10-dihydro-10-hydroxy-retinyl acetate, an starting material for the production of vitamin A acetate.

    摘要翻译： 一种制备下式化合物的方法，其中R表示C1-23-烷基或含1〜3个双键的C2-23链烯基，包括以下步骤：（a）使式的化合物与酰化剂反应， 是在（i）有机溶剂和（ii）存在于悬浮液中的脂肪酶的混合物中，以形成式I化合物; 和（b）回收式I化合物。 该方法可用于制备（11Z，13Z）-7,10-二氢-10-羟基 - 视黄基乙酸酯，一种生产维生素A乙酸酯的原料。

    Phosphine ligands
    9.
    发明授权
    Phosphine ligands 失效
    膦配体

    公开(公告)号：US07642366B2

    公开(公告)日：2010-01-05

    申请号：US11591277

    申请日：2006-11-01

    申请人： Hans Iding ,  Ernst Kupfer ,  Bruno Lohri ,  Kazimierz Michal Pietrusiewicz ,  Kurt Puentener ,  Michelangelo Scalone ,  Wioleta Swierczynska ,  Beat Wirz

    发明人： Hans Iding ,  Ernst Kupfer ,  Bruno Lohri ,  Kazimierz Michal Pietrusiewicz ,  Kurt Puentener ,  Michelangelo Scalone ,  Wioleta Swierczynska ,  Beat Wirz

    IPC分类号： C07F15/04

    CPC分类号： C07F15/006 ,  C07B53/00 ,  C07F9/65683 ,  C07F15/0066

    摘要： The invention is concerned with new phosphine ligands of the formula I wherein R1 and R2 are independently of each other alkyl, aryl, cycloalkyl or heteroaryl, said alkyl, aryl, cycloalkyl or heteroaryl may be substituted by alkyl, alkoxy, halogen, hydroxy, amino, mono- or dialkylamino, aryl, —SO2—R7, —SO3−, —CO—NR8R8′, carboxy, alkoxycarbonyl, trialkylsilyl, diarylalkylsilyl, dialkylarylsilyl or triarylsilyl; R3 is alkyl, cycloalkyl, aryl or heteroaryl; R4′ and R4 signify independently of each other hydrogen, alkyl or optionally substituted aryl; or R4′ and R4 together with the C-atom they are attached to form a 3-8-membered carbocyclic ring; dotted line is absent or is present and forms a double bond; R5 and R6 are independently of each other hydrogen, alkyl or aryl; or linked together to form a 3-8-membered carbocyclic ring or an aromatic ring; R7 is alkyl, aryl or NR8R8′; and R8 and R8′ are independently of each other hydrogen, alkyl or aryl; metal complexes with such ligands as well as the use of such metal complexes as catalysts in asymmetric reactions.

    摘要翻译： 本发明涉及式I的新膦配体，其中R 1和R 2彼此独立地为烷基，芳基，环烷基或杂芳基，所述烷基，芳基，环烷基或杂芳基可以被烷基，烷氧基，卤素，羟基，氨基 ，一或二烷基氨基，芳基，-SO 2 -R 7，-SO 3 - ，-CO-NR 8 R 8'，羧基，烷氧基羰基，三烷基甲硅烷基，二芳基烷基甲硅烷基，二烷基芳基甲硅烷基或三芳基甲硅烷基; R3是烷基，环烷基，芳基或杂芳基; R4'和R4独立地表示氢，烷基或任选取代的芳基; 或R 4'和R 4与它们所连接的C原子一起形成3-8-元碳环; 虚线不存在或存在并形成双键; R5和R6彼此独立地为氢，烷基或芳基; 或连接在一起形成3-8元碳环或芳环; R7是烷基，芳基或NR8R8'; R8和R8'彼此独立地为氢，烷基或芳基; 与这种配体的金属络合物以及在不对称反应中使用这样的金属络合物作为催化剂。