公开(公告)号：US09878970B1

公开(公告)日：2018-01-30

申请号：US15717327

申请日：2017-09-27

申请人： Syngenta Crop Protection, LLC

发明人： Denis Gribkov ,  Bjorn Antelmann ,  Fanny Bois ,  Harald Walter ,  Alain De Mesmaeker

IPC分类号： C07C22/02 ,  C07C22/04 ,  C07C205/06 ,  C07C205/11 ,  C07C205/12 ,  C07C17/32 ,  C07C17/266 ,  C07C209/36 ,  C07C17/23 ,  C07C17/26 ,  C07C201/12

CPC分类号： C07C17/32 ,  C07C17/23 ,  C07C17/26 ,  C07C17/266 ,  C07C22/02 ,  C07C22/04 ,  C07C201/12 ,  C07C205/06 ,  C07C205/11 ,  C07C205/12 ,  C07C209/365 ,  C07C2601/10 ,  C07C2603/66 ,  C07C211/61

摘要： The present invention relates to a novel a process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCl3, wherein X is chloro or bromo, to a compound of formula I1, or aa) reacting cyclopentadiene with CXCl3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula I1, wherein X is chloro, b) reacting the compound of formula I1 with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV, and d) hydrogenating the compound of formula IV in the presence of a metal catalyst.