公开(公告)号：US10266508B2

公开(公告)日：2019-04-23

申请号：US15736037

申请日：2016-07-01

Applicant: Synvina C.V.

Inventor： Johannes Maria Franciscus Sijben ,  Etienne Mazoyer ,  Ana Sofia Vagueiro De Sousa Dias ,  Gerardus Johannes Maria Gruter

IPC: C07D307/46 ,  C07D307/48

Abstract: A furfural derivative having the chemical formula (1) where R represents hydrogen, an alkyl group or an acyl group, is prepared in a process, which process includes reacting a fructose- and/or glucose-containing starting material with a liquid hydroxyl group-containing compound of formula R—OH in the presence of an acid catalyst at a reaction temperature in the range of 150 to 300° C. to produce a primary acid reaction mixture including the furfural derivative of chemical formula (1); separating part of the liquid hydroxyl group-containing compound from the primary acid reaction mixture to yield a secondary acid reaction mixture; neutralizing the secondary acid reaction mixture to a pH-value of at least 3 to obtain a neutralized reaction mixture; and purifying the neutralized reaction mixture to recover the furfural derivative of chemical formula (1).

公开(公告)号：US20180186761A1

公开(公告)日：2018-07-05

申请号：US15736037

申请日：2016-07-01

Applicant: Synvina C.V.

Inventor： Johannes Maria Franciscus Sijben ,  Etienne Mazoyer ,  Ana Sofia Vagueiro De Sousa Dias ,  Gerardus Johannes Maria Gruter

IPC: C07D307/48

CPC classification number: C07D307/48 ,  C07D307/46

Abstract: A furfural derivative having the chemical formula (1) where R represents hydrogen, an alkyl group or an acyl group, is prepared in a process, which process includes reacting a fructose-and/or glucose-containing starting material with a liquid hydroxyl group-containing compound of formula R—OH in the presence of an acid catalyst at a reaction temperature in the range of 150 to 300° C. to produce a primary acid reaction mixture including the furfural derivative of chemical formula (1); separating part of the liquid hydroxyl group-containing compound from the primary acid reaction mixture to yield a secondary acid reaction mixture; neutralizing the secondary acid reaction mixture to a pH-value of at least 3 to obtain a neutralized reaction mixture; and purifying the neutralized reaction mixture to recover the furfural derivative of chemical formula (1).

公开(公告)号：US20180170890A1

公开(公告)日：2018-06-21

申请号：US15736033

申请日：2016-07-01

Applicant: Synvina C.V.

Inventor： Johannes Maria Franciscus Sijben ,  Etienne Mazoyer ,  Ana Sofia Vagueiro De Sousa Dias ,  Gerardus Johannes Maria Gruter

IPC: C07D307/50

CPC classification number: C07D307/50

Abstract: A furfural derivative having the chemical formula (1) wherein R represents hydrogen, an alkyl group or an acyl group, is prepared in a process, which process includes reacting a fructose- and/or glucose-containing starting material with a liquid hydroxyl group-containing compound of formula R—OH in the presence of an acid catalyst at a reaction temperature in the range of 150 to 300° C. to produce an acid reaction mixture including the furfural derivative of chemical formula (1), which acid reaction mixture has a pH-value of smaller than 3; neutralizing the acid reaction mixture to a pH-value in the range of 3 to 6.5 to provide a partially neutralized reaction mixture; and purifying the partially neutralized reaction mixture to recover the furfural derivative of chemical formula (1).

公开(公告)号：US10351543B2

公开(公告)日：2019-07-16

申请号：US15736033

申请日：2016-07-01

Applicant: Synvina C.V.

Inventor： Johannes Maria Franciscus Sijben ,  Etienne Mazoyer ,  Ana Sofia Vagueiro De Sousa Dias ,  Gerardus Johannes Maria Gruter

IPC: C07D307/50

Abstract: A furfural derivative having the chemical formula (1) wherein R represents hydrogen, an alkyl group or an acyl group, is prepared in a process, which process includes reacting a fructose- and/or glucose-containing starting material with a liquid hydroxyl group-containing compound of formula R—OH in the presence of an acid catalyst at a reaction temperature in the range of 150 to 300° C. to produce an acid reaction mixture including the furfural derivative of chemical formula (1), which acid reaction mixture has a pH-value of smaller than 3; neutralizing the acid reaction mixture to a pH-value in the range of 3 to 6.5 to provide a partially neutralized reaction mixture; and purifying the partially neutralized reaction mixture to recover the furfural derivative of chemical formula (1).