公开(公告)号：US09815938B2

公开(公告)日：2017-11-14

申请号：US14392185

申请日：2014-06-25

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Mitsuhisa Yamano ,  Toshiaki Nagata ,  Hideki Saitoh

IPC: A61K47/34 ,  C08G69/08 ,  C08G69/10 ,  C08G69/48 ,  A61K39/39 ,  C08L77/04 ,  A61K39/00

CPC classification number: C08G69/48 ,  A61K39/39 ,  A61K47/34 ,  A61K2039/55555 ,  A61K2039/6093 ,  C08G69/08 ,  C08G69/10 ,  C08L77/04

Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (γ-PGA-PAE) of poly(γ-glutamic acid) (γ-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.

公开(公告)号：US10336864B2

公开(公告)日：2019-07-02

申请号：US15727760

申请日：2017-10-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Mitsuhisa Yamano ,  Toshiaki Nagata ,  Hideki Saitoh

IPC: A61K47/42 ,  C08G69/08 ,  C08G69/10 ,  C08G69/48 ,  A61K47/34 ,  A61K39/39 ,  C08L77/04 ,  A61K39/00

Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (γ-PGA-PAE) of poly(γ-glutamic acid) (γ-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.