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Patent Agency Ranking
公开(公告)号：US09238667B2
公开(公告)日：2016-01-19
申请号：US14388383
申请日：2013-03-28
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Mitsuhisa Yamano , Masatoshi Yamada , Hirotsugu Usutani
IPC: C07F15/00 , B01J31/24 , C07B53/00 , C07D471/04 , C07F9/50 , C07C231/18 , C07C309/30 , C07C241/04 , C07C51/41
CPC classification number: C07F15/0073 , B01J31/24 , B01J31/2495 , B01J2231/645 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07C51/412 , C07C231/18 , C07C241/04 , C07C309/30 , C07C2601/14 , C07C2601/16 , C07D471/04 , C07F9/5027 , C07C243/38 , C07C233/47 , C07C233/81 , C07C59/255
Abstract: [Problem] Provision of a superior rhodium catalyst and a production method of amine compound.[Solving Means] A rhodium complex coordinated with a compound represented by the formula
Abstract translation: [问题]提供优异的铑催化剂和胺化合物的制备方法。 [解决方案]与由式表示的化合物配位的铑络合物
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公开(公告)号：US08981147B2
公开(公告)日：2015-03-17
申请号：US14183827
申请日：2014-02-19
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Mitsuhisa Yamano , Mitsutaka Goto , Shinji Kawaguchi , Masatoshi Yamada , Jun-ichi Kawakami
CPC classification number: C07F9/572 , B01J31/2452 , B01J2531/80 , C07B53/00 , C07F9/5022 , C07F9/5027 , C07F15/004 , C07F15/0053 , C07F15/0066 , C07F15/008
Abstract: The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions.A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).
Abstract translation: 本发明提供了由下式表示的新型配位体和具有配位体的新型过渡金属络合物，其在各种不对称合成反应中表现出优异的对映体选择性和催化效率，特别高的催化剂活性。 一种具有下式表示的化合物作为配体的过渡金属配合物，其中R 4为氢原子或任选具有取代基的C 1-6烷基，R 5和R 6各自为任选具有 取代基，或式为由下式表示的基团：其中环B为任选具有取代基的3-至8-元环。
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公开(公告)号：US20170081305A1
公开(公告)日：2017-03-23
申请号：US15125299
申请日：2015-03-13
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Masatoshi Yamada , Sayuri HIRANO , Ryoji TSURUOKA , Mitsuhisa YAMANO
IPC: C07D401/04 , B01J31/24 , C07F15/00 , C07F17/02 , C07D211/78 , C07D211/60
CPC classification number: C07D401/04 , B01J31/2226 , B01J31/2295 , B01J31/2409 , B01J31/2452 , B01J2231/645 , B01J2531/0205 , B01J2531/0263 , B01J2531/0266 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/842 , B01J2540/225 , C07B2200/07 , C07D211/60 , C07D211/78 , C07F9/5027 , C07F15/0046 , C07F17/02
Abstract: The present invention provides a method of efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative.The optically active piperidine-3-carboxamide or a derivative thereof, which is obtained by subjecting 1,4,5,6-tetrahydropyridine-3-carboxamide or a derivative thereof to an asymmetric reduction in the presence of a catalyst, is used as an intermediate.
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公开(公告)号：US09809569B2
公开(公告)日：2017-11-07
申请号：US15125299
申请日：2015-03-13
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Masatoshi Yamada , Sayuri Hirano , Ryoji Tsuruoka , Mitsuhisa Yamano
IPC: C07D401/04 , C07D211/60 , C07D211/78 , C07F17/02 , B01J31/24 , C07F9/50 , C07F15/00 , B01J31/22
CPC classification number: C07D401/04 , B01J31/2226 , B01J31/2295 , B01J31/2409 , B01J31/2452 , B01J2231/645 , B01J2531/0205 , B01J2531/0263 , B01J2531/0266 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/842 , B01J2540/225 , C07B2200/07 , C07D211/60 , C07D211/78 , C07F9/5027 , C07F15/0046 , C07F17/02
Abstract: The present invention provides a method of efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo -1,2,3,4-tetrahydropyrimidine derivative.The optically active piperidine-3-carboxamide or a derivative thereof, which is obtained by subjecting 1,4,5,6-tetrahydropyridine -3-carboxamide or a derivative thereof to an asymmetric reduction in the presence of a catalyst, is used as an intermediate.
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公开(公告)号：US20150051416A1
公开(公告)日：2015-02-19
申请号：US14388383
申请日：2013-03-28
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Mitsuhisa Yamano , Masatoshi Yamada , Hirotsugu Usutani
CPC classification number: C07F15/0073 , B01J31/24 , B01J31/2495 , B01J2231/645 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07C51/412 , C07C231/18 , C07C241/04 , C07C309/30 , C07C2601/14 , C07C2601/16 , C07D471/04 , C07F9/5027 , C07C243/38 , C07C233/47 , C07C233/81 , C07C59/255
Abstract: [Problem] Provision of a superior rhodium catalyst and a production method of amine compound.[Solving Means] A rhodium complex coordinated with a compound represented by the formula
Abstract translation: [问题]提供优异的铑催化剂和胺化合物的制备方法。 [解决方案]与由式表示的化合物配位的铑络合物
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