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公开(公告)号：US20180319819A1
公开(公告)日：2018-11-08
申请号：US15769201
申请日：2016-10-21
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Takatoshi YOGO , Masato YOSHIKAWA , Morihisa SAITOH , Taisuke KATOH , Tomohiro SEKI , Yoshihisa NAKADA
IPC: C07D519/00 , A61P25/00
CPC classification number: C07D519/00 , A61K31/55 , A61K31/553 , A61K31/554 , A61P1/16 , A61P13/12 , A61P25/00 , A61P31/12 , C07D471/04 , C07D487/04 , C07D513/04
Abstract: The present invention provides a heterocyclic compound having an RIP1 kinase inhibitory action, which is useful for the prophylaxis or treatment of Gaucher's disease, Niemann-Pick disease, inflammatory bowel disease, multiple sclerosis, chronic kidney disease, acute kidney injury, acute hepatic failure, autoimmune hepatitis, hepatitis B, hepatitis C, alcohol steatohepatitis, non-alcohol steatohepatitis and the like.The present invention relates to a compound represented by the following formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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Patent Agency Ranking
公开(公告)号：US20180118708A1
公开(公告)日：2018-05-03
申请号：US15572231
申请日：2016-05-06
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Toshitake KOBAYASHI , Morihisa SAITOH , Yasufumi WADA , Hiroshi NARA , Nobuyuki NEGORO , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
CPC classification number: C07D317/72 , A61K31/357 , A61P1/16 , A61P9/10 , A61P25/02 , A61P29/00 , A61P37/00
Abstract: The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of autoimmune disease and/or inflammatory disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like.The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
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公开(公告)号：US20170066737A1
公开(公告)日：2017-03-09
申请号：US15356906
申请日：2016-11-21
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Toshitake Kobayashi , Morihisa SAITOH , Yasufumi WADA , Hiroshi NARA , Nobuyuki NEGORO , Taisuke KATOH , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
IPC: C07D317/72 , C07C317/46 , C07D309/28 , C07C317/44
CPC classification number: C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
Abstract: The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: wherein, each symbol is explained in greater detail in the specification.
Abstract translation: 其中，在说明书中更详细地说明每个符号。
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公开(公告)号：US20160326133A1
公开(公告)日：2016-11-10
申请号：US15175292
申请日：2016-06-07
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Toshitake Kobayashi , Morihisa SAITOH , Yasufumi WADA , Hiroshi NARA , Nobuyuki NEGORO , Taisuke KATOH , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
IPC: C07D317/72
CPC classification number: C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
Abstract: The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
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公开(公告)号：US20190233370A1
公开(公告)日：2019-08-01
申请号：US16331962
申请日：2017-09-07
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Toshitake KOBAYASHI , Morihisa SAITOH , Yasufumi WADA , Nobuyuki NEGORO , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
Abstract: The present invention provides a compound having a superior Toll-like receptor 4 (TLR4) signaling inhibitory action, which may be useful as a prophylactic or therapeutic drug for diseases such as autoimmune diseases and/or inflammatory diseases, or chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver failure, and ischemia reperfusion injury (IRI).The present invention relates to ethyl 6-((2-chloro-4-fluorobenzyl)sulfonyl)-3-hydroxycyclohex-1-ene-1-carboxylate or an optical isomer thereof.
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公开(公告)号：US20160326102A1
公开(公告)日：2016-11-10
申请号：US15148210
申请日：2016-05-06
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Toshitake Kobayashi , Morihisa SAITOH , Yasufumi WADA , Hiroshi NARA , Nobuyuki NEGORO , Taisuke KATOH , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
IPC: C07C317/12 , C07D309/28 , C07D317/72
CPC classification number: C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
Abstract: The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like.The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
Abstract translation: （其中，在说明书中更详细地说明每个符号）。
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