公开(公告)号：US09221836B2

公开(公告)日：2015-12-29

申请号：US14665237

申请日：2015-03-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Takanobu Kuroita ,  Yasuhiro Imaeda ,  Kouichi Iwanaga ,  Naohiro Taya ,  Hidekazu Tokuhara

IPC: A61K31/445 ,  C07D401/12 ,  C07D495/04 ,  C07D233/90 ,  C07D401/14 ,  C07D407/12 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D405/14

CPC classification number: C07D401/12 ,  C07D233/90 ,  C07D401/14 ,  C07D405/14 ,  C07D407/12 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04

Abstract: Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.