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公开(公告)号：US20200377509A1
公开(公告)日：2020-12-03
申请号：US16497141
申请日：2018-03-29
发明人： Seiji MIWATASHI , Yasufumi MIYAMOTO , Koji WATANABE , Yayoi NAKAYAMA , Yuko HITOMI , Jumpei AIDA , Nobuyuki TAKAKURA , Hideki FURUKAWA , Naoyoshi NOGUCHI , Yasuhiro HIRATA , Shizuo KASAl , Toshitake KOBAYASHI , Tsuyoshi MAEKAWA , Satoshi SASAKI , Shigemitsu MATSUMOTO
IPC分类号： C07D491/052 , C07D401/12 , C07D401/14 , C07D211/22
摘要： Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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公开(公告)号：US20200039957A1
公开(公告)日：2020-02-06
申请号：US16499432
申请日：2018-03-29
发明人： Seiji MIWATASHI , Yasufumi MIYAMOTO , Koji WATANABE , Yayoi NAKAYAMA , Yuko HITOMI , Jumpei AIDA , Nobuyuki TAKAKURA , Hideki FURUKAWA , Naoyoshi NOGUCHI , Yasuhiro HIRATA , Kazuaki TAKAMI , Norihito TOKUNAGA , Tomohiro OKAWA , Akita SHIBUYA , Shizuo KASAl , Toshitake KOBAYASHI , Tsuyoshi MAEKAWA
IPC分类号： C07D401/12 , C07D211/22 , C07D401/14 , C07C59/72 , C07D213/64 , C07D401/10 , C07D413/10
摘要： Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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