公开(公告)号：US10180441B2

公开(公告)日：2019-01-15

申请号：US14870673

申请日：2015-09-30

Applicant: TECAN Trading AG

Inventor： Florian Reiner ,  Harald Gebethsroither ,  Josef Grassl

IPC: C12M1/00 ,  G01N35/02 ,  C12M1/04 ,  G01N33/50 ,  G01N21/64 ,  C12M1/34 ,  G01N21/25 ,  C12Q1/02 ,  B01L9/00 ,  G01J3/12 ,  G01N35/00

Abstract: The invention relates to a microplate reader and a respective method, wherein the microplate reader comprises at least one measuring device and a holding device for accommodating at least one microplate and for positioning the samples-containing wells of this(these) microplate(s) in relation to the at least one measuring device. The at least one measuring device is used for detecting light which is emitted by samples in wells of a microplate inserted in this microplate reader and/or which is influenced by samples transilluminated by light in wells of a microplate inserted in this microplate reader. The microplate reader comprises a control unit for controlling the temperature of a gas atmosphere surrounding the wells containing the samples of microplates used in this microplate reader.

公开(公告)号：US11442260B2

公开(公告)日：2022-09-13

申请号：US16041922

申请日：2018-07-23

Applicant: TECAN TRADING AG

Inventor： Andreas Erlbacher ,  Markus Schürf ,  Josef Grassl ,  Alexander Kaser

IPC: G02B21/00 ,  G02B7/36 ,  G02B7/32 ,  G02B21/24 ,  G02B21/06 ,  G02B21/36

Abstract: A system 100 and method are provided for imaging a sample in a sample holder. For providing autofocus, a 2D pattern is projected onto the sample holder 050 via an astigmatic optical element 120. Image data 172 of the sample is acquired by an image sensor 140 via magnification optics 150. A difference in sharpness of the two-dimensional pattern in the image data is measured along a first axis and a second axis. Based on the difference, a magnitude and direction of defocus of the camera subsystem is determined with respect to the sample holder. This enables the sample holder, and thereby the sample, to be brought into focus in a fast and reliable manner.