公开(公告)号：US20210402402A1

公开(公告)日：2021-12-30

申请号：US17470669

申请日：2021-09-09

Applicant: TECAN TRADING AG

Inventor： Manjeet DHINDSA ,  Khushroo GANDHI

IPC: B01L3/00

Abstract: A cartridge configured to control and manipulate liquids and to be positioned at a cartridge accommodation site of a digital microfluidics system is disclosed. The digital microfluidics system has a number or array of individual electrodes attached to a first substrate or PCB, a central control unit in operative contact with individual electrodes for controlling selection and for providing a number of individual electrodes that define a path of individual electrodes with voltage for manipulating liquid portions or liquid droplets by electrowetting, and a cartridge accommodation site that is configured for taking up the cartridge.

公开(公告)号：US20180243743A1

公开(公告)日：2018-08-30

申请号：US15756176

申请日：2015-09-02

Applicant: Thoms PERROUD ,  Dan TRAN ,  Daniel HOFFMEYER ,  Tiffany LAY ,  Manjeet DHINDSA ,  TECAN TRADING AG

Inventor： THOMAS PERROUD ,  Dan TRAN ,  Daniel HOFFMEYER ,  Tiffany LAY ,  Manjeet DHINDSA

IPC: B01L3/00

CPC classification number: C02F1/484 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502792 ,  B01L3/508 ,  B01L2200/025 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/123 ,  B01L2400/0427 ,  B01L2400/043

Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface, and a control unit for manipulating liquid droplets by electrowetting; providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface; providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads; moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit; actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads; and while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

公开(公告)号：US20210402401A1

公开(公告)日：2021-12-30

申请号：US17469656

申请日：2021-09-08

Applicant: TECAN TRADING AG

Inventor： Thomas PERROUD ,  Dan TRAN ,  Daniel HOFFMEYER ,  Tiffany LAY ,  Manjeet DHINDSA

IPC: B01L3/00

Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface and a control unit for manipulating liquid droplets by electrowetting, providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface, providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit, actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

公开(公告)号：US20180339923A1

公开(公告)日：2018-11-29

申请号：US15756209

申请日：2016-09-01

Applicant: TECAN TRADING AG

Inventor： Thomas PERROUD ,  Dan TRAN ,  Daniel HOFFMEYER ,  Tiffany LAY ,  Manjeet DHINDSA

IPC: C02F1/48

Abstract: Digital microfluidics system with electrodes attached to a PCB has control unit for manipulating liquid droplets by electrowetting, cartridge accommodation site for taking up a disposable cartridge having a working gap in-between two hydrophobic surfaces, and magnetic conduit/backing combination. A barrier element on an individual electrode of the PCB for narrowing the working gap. A disposable cartridge is positioned at the cartridge accommodation site, its flexible working film touching there and of the barrier element an uppermost surface. In the working gap and above a path of selected electrodes a liquid portion or liquid droplet with magnetically responsive beads moves by electrowetting on the electrode path until a magnetic field of the magnetic conduit is reached. The backing magnet is activated before and during the moving to thereby attract and remove magnetically responsive beads therefrom.