公开(公告)号：US20160082437A1

公开(公告)日：2016-03-24

申请号：US14943520

申请日：2015-11-17

Applicant: TECAN TRADING AG

Inventor： Thomas PERROUD ,  Daniel HOFFMEYER ,  Adrian SAGER ,  Anne KOPF-SILL

IPC: B01L3/00

CPC classification number: B01L3/502792 ,  B01L3/0275 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2300/041 ,  B01L2300/046 ,  B01L2300/0816 ,  B01L2300/161 ,  B01L2300/165 ,  B01L2400/0427 ,  B01L2400/0478 ,  G01N2001/1056

Abstract: A cover (10) for use in a digital microfluidics system (16) for manipulating samples in liquid portions or droplets. The digital microfluidics system (16) includes a first substrate (18) with an array of electrodes (24) and a central control unit (20) for controlling the selection and for providing a number of the electrodes with voltage for manipulating liquid portions or droplets by electrowetting. A working gap (30) with a gap height is located parallel to the array of electrodes (24) and in-between first and second hydrophobic surfaces (26,28) that face each other at least during operation of the digital microfluidics system (16).

Abstract translation: 一种用于数字微流体系统（16）中的用于操纵液体部分或液滴中的样品的盖（10）。 数字微流体系统（16）包括具有电极阵列（24）和中央控制单元（20）的第一衬底（18），用于控制选择并为多个电极提供用于操纵液体部分或液滴的电压 通过电润湿。 具有间隙高度的工作间隙（30）至少在数字微流体系统（16）的操作期间平行于电极阵列（24）并且位于彼此面对的第一和第二疏水表面（26,28）之间 ）。

公开(公告)号：US20210402401A1

公开(公告)日：2021-12-30

申请号：US17469656

申请日：2021-09-08

Applicant: TECAN TRADING AG

Inventor： Thomas PERROUD ,  Dan TRAN ,  Daniel HOFFMEYER ,  Tiffany LAY ,  Manjeet DHINDSA

IPC: B01L3/00

Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface and a control unit for manipulating liquid droplets by electrowetting, providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface, providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit, actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

公开(公告)号：US20180339923A1

公开(公告)日：2018-11-29

申请号：US15756209

申请日：2016-09-01

Applicant: TECAN TRADING AG

Inventor： Thomas PERROUD ,  Dan TRAN ,  Daniel HOFFMEYER ,  Tiffany LAY ,  Manjeet DHINDSA

IPC: C02F1/48

Abstract: Digital microfluidics system with electrodes attached to a PCB has control unit for manipulating liquid droplets by electrowetting, cartridge accommodation site for taking up a disposable cartridge having a working gap in-between two hydrophobic surfaces, and magnetic conduit/backing combination. A barrier element on an individual electrode of the PCB for narrowing the working gap. A disposable cartridge is positioned at the cartridge accommodation site, its flexible working film touching there and of the barrier element an uppermost surface. In the working gap and above a path of selected electrodes a liquid portion or liquid droplet with magnetically responsive beads moves by electrowetting on the electrode path until a magnetic field of the magnetic conduit is reached. The backing magnet is activated before and during the moving to thereby attract and remove magnetically responsive beads therefrom.