公开(公告)号：US20240418611A1

公开(公告)日：2024-12-19

申请号：US18723218

申请日：2022-12-22

Applicant: TECAN TRADING AG

Inventor： Philipp OTT ,  Patrick KINNEY ,  Adrian SAGER

IPC: G01N1/31

Abstract: Some embodiments are directed to a method for detaching tissue from a tissue section on a tissue slide. The method may include applying a 3D printed mask on top of the tissue section, the mask comprising barriers that define a cavity surrounding an area of interest on the tissue section, the cavity being open at a side facing the area of interest on the tissue section, dispensing a detaching liquid to the cavity, and allowing the detaching liquid to detach tissue at the area of interest, and aspirating the detaching liquid with the detached tissue from the cavity, and forwarding the liquid for further processing.

公开(公告)号：US20230152338A1

公开(公告)日：2023-05-18

申请号：US17980009

申请日：2022-11-03

Applicant: TECAN TRADING AG

Inventor： Philipp OTT ,  Yves WURMITZER ,  Volfgang VILAJ

IPC: G01N35/00 ,  G01N1/34 ,  G01N35/10

CPC classification number: G01N35/00029 ,  G01N1/34 ,  G01N35/1009

Abstract: Some embodiments are directed to a method for tracking lysis progress in an automated lysing device. For example, the lysing device may be configured to execute multiple iterations of lysing at a defined location on the tissue section and imaging the defined location on the tissue section using a camera. From the images a lysing parameter may be determined to improve lysing.

公开(公告)号：US20210094028A1

公开(公告)日：2021-04-01

申请号：US16954793

申请日：2018-12-17

Applicant: TECAN TRADING AG

Inventor： Philipp OTT ,  Dominic ERB

IPC: B01L3/02 ,  G01N35/10

Abstract: A pipetting apparatus and method capable of detecting a liquid within an intermediate section of a pipette tube of the pipetting apparatus. The intermediate section is located between an upper section of the pipette tube at which a first electrode is arranged and a lower section at which a second electrode is arranged. The first and second electrodes form a measurement capacitor and are operationally connected to an impedance measurement unit, which is adapted to detect whether liquid, such as a portion of a sample liquid or system liquid, is present within the intermediate section based on the measured impedance or change of impedance, e.g. an increase of the capacitance and/or a decrease of the resistance, of the measurement capacitor caused by a presence of the liquid within the intermediate section.

公开(公告)号：US20210077992A1

公开(公告)日：2021-03-18

申请号：US16954414

申请日：2018-12-12

Applicant: TECAN TRADING AG

Inventor： Philipp OTT

IPC: B01L3/02 ,  G01N11/04 ,  G01N13/02 ,  G01N35/10

Abstract: A pipetting apparatus having a pipette tube with a first end provided with an opening for aspirating and/or dispensing of a sample fluid and a second end operationally connected to a pressure generating means. The pipetting apparatus has at least one measuring unit adapted to determine at least one measurement value of the sample fluid based on the aspirating and/or dispensing of the sample fluid and to provide a sample fluid measurement signal representative thereof to an output of the measuring unit. The pipetting apparatus also has a control circuit operationally coupled to the output of the measuring unit and the input of the pressure generating means, the control circuit is configured to control said pressure generating device based on the sample fluid measurement signal.

公开(公告)号：US20240207837A1

公开(公告)日：2024-06-27

申请号：US18390556

申请日：2023-12-20

Applicant: TECAN TRADING AG

Inventor： Philipp OTT ,  Adrian SAGER ,  Luca FREI

IPC: B01L3/02 ,  G01N35/10

CPC classification number: B01L3/0275 ,  G01N35/10 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2300/0681 ,  G01N2035/103

Abstract: A pipette tip adapter (1) is detachably connectable between a pipetting device (10) and a pipette tip (15). The pipette tip adapter has a body (2) with an interior compartment (7) for holding a liquid (18), a recess (3) entering into a part of the body (2) for detachably receiving a connector (11) of the pipetting device (10) and having a first opening (5) pneumatically connected with the interior compartment (7). The pipette tip adapter (1) further has a tube section (4) projecting from the pipette tip adapter (1) detachably securable with a pipette tip (15) and having a second opening (6) hydraulically connected with the interior compartment (7). The pipette tip adapter (1) may be used in an automated pipetting system (100). An automated pipetting system (100) having a pipette tip adapter (1) for preparing liquid reactions is also disclosed.

公开(公告)号：US20220401958A1

公开(公告)日：2022-12-22

申请号：US17630037

申请日：2020-08-03

Applicant: TECAN TRADING AG

Inventor： Philipp OTT ,  Adrian SAGER ,  Lars Johan BRANDEN

IPC: B01L3/00 ,  B01L3/02

Abstract: A cover for a fluid container having an essentially plane cover plate for closing at least one opening of at least one fluid container and at least two ports, and each port has a through channel extending through the entire thickness of the cover plate and a fluid impermeable first membrane is arranged over the entire cross section of the through channel of the first port and an at least gas permeable second membrane is arranged over the entire cross section of the through channel of the second port is disclosed.

公开(公告)号：US20220034420A1

公开(公告)日：2022-02-03

申请号：US17276731

申请日：2019-09-20

Applicant: TECAN TRADING AG

Inventor： Philipp OTT

IPC: F16K31/06 ,  B01L3/02 ,  G01F11/12 ,  G01F13/00

Abstract: A method for controlling a magnetic valve and particularly a method for dispensing and/or aspirating a volume of liquid as well as a corresponding dispenser/pipetting apparatus is disclosed. The method for controlling a magnetic valve has measuring a capacitance at the magnetic valve and determining a position of a plunger based on the measured capacitance. The method for dispensing or aspirating a volume of liquid has controlling a flow of a system fluid by a magnetic valve located between a pressure source and a dispenser/pipetting tip, dispensing or aspirating a volume of liquid through an exterior opening of the tip dependent on the flow of the system fluid, wherein controlling the flow and determining a flow time in dependence of the volume of liquid to be dispensed or aspirated, and controlling the magnetic valve is held open for the duration of the flow time.

公开(公告)号：US20220023854A1

公开(公告)日：2022-01-27

申请号：US17295624

申请日：2019-12-20

Applicant: Adrian SAGER ,  Philipp OTT ,  Patrick KINNEY ,  Hagen REINHARDT ,  Michael KELLER ,  Sujata IYER ,  TECAN TRADING AG

Inventor： Adrian SAGER ,  Philipp OTT ,  Patrick KINNEY ,  Hagen REINHARDT ,  Michael KELLER ,  Sujata IYER

IPC: B01L3/02 ,  G01N35/10

Abstract: A pipette tip extension attachable to a pipette tip having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip, and at the distal end a dispense aperture. The pipette tip extension further has an inner cavity, a distance element connected to the inner side of the exterior wall, and a constriction element.

公开(公告)号：US20190143317A1

公开(公告)日：2019-05-16

申请号：US16308783

申请日：2017-07-21

Applicant: TECAN TRADING AG

Inventor： Philipp OTT ,  Matthias DZUNG ,  Martin KUSTER

IPC: B01L3/02 ,  G01D5/241 ,  G01N35/00 ,  G01N35/10

Abstract: The invention concerns pipette tips for connecting to a pipette tube of a pipetting device are used for taking up and discharging fluids. The pipette tip is in the shape of an elongated tube forming a pipette body that has an opening at one end and is designed for connecting to the pipette tube at the other end. The pipette tip has a first electrode as a volume measuring electrode of a measuring capacitor and a second electrode as an immersion detector electrode. The first electrode is located on an outer surface of the pipette body or is embedded in the pipette body, and the second electrode is located at least partially on an inner surface of the pipette body.

公开(公告)号：US20240193769A1

公开(公告)日：2024-06-13

申请号：US18535589

申请日：2023-12-11

Applicant: Tecan Trading AG

Inventor： Volfgang VILAJ ,  Simon STRASSEN ,  Philipp OTT

IPC: G06T7/00 ,  G06T7/12 ,  G06T7/64 ,  G06T11/20

CPC classification number: G06T7/0012 ,  G06T7/12 ,  G06T7/64 ,  G06T11/203 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30088

Abstract: Some embodiments are directed to completing incomplete area of interest markings. An area of interest marking indicates an area of interest on an image of a tissue section. The method may include detecting in the image endpoints of the one or more contours, and drawing in the image a segment connecting the matching endpoints in a selected pair.