公开(公告)号：US20240409680A1

公开(公告)日：2024-12-12

申请号：US18702135

申请日：2022-11-10

Applicant: Technion Research and Development Foundation Limited

Inventor： Hossam HAICK ,  Ning TANG

IPC: C08G18/75 ,  A61L15/26 ,  C08G18/10 ,  C08G18/38 ,  C08G18/69

Abstract: The present invention provides a self-healing biocompatible elastomer comprising polymeric chains comprising units of formula (A1), wherein R1 is selected from the group consisting of a linear (C2-C20) alkylene and —R4-S—S—R4′-, wherein R4 and R4′ are independently a linear (C1-C10) alkylene; R2 is a linear or cyclic (C4-C10) alkylene; and R3 is selected from the group consisting of a polybutadiene, a polybutene, a polyethylene, a polypropylene, and a polyisoprene, wherein the elastomer is crosslinked by hydrogen bonds between urethane linkages. Further provided is a one-pot method for preparing a self-healing biocompatible elastomer. The invention further provides an antibacterial composition and a wound dressing comprising the self-healing biocompatible elastomer. Formula (A1)

公开(公告)号：US20220091097A1

公开(公告)日：2022-03-24

申请号：US17540359

申请日：2021-12-02

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED

Inventor： Hossam HAICK ,  Weiwei Wu

IPC: G01N33/497 ,  G01K7/18 ,  G01L19/00

Abstract: The present invention provides a vapor-permeable flexible sensing platform unit comprising: a first porous membrane, wherein said membrane is substantially flexible and hydrophobic; and a volatile organic compounds (VOCs) sensor disposed on said membrane, the VOCs sensor comprising an electrode array and a conducting polymer porous film being in electric contact with said electrode array, wherein the VOCs sensor is insensitive to lateral strain. Further provided are a method of preparation of said platform unit and a lift-off, float-on (LOFO) method for the preparation of protonically doped polyaniline (PANI) thin films.

公开(公告)号：US20230117378A1

公开(公告)日：2023-04-20

申请号：US18067702

申请日：2022-12-17

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED

Inventor： Hossam HAICK ,  Muhammad KHATIB

IPC: H01L29/786 ,  H01L29/06 ,  H01L29/16 ,  H01L29/24 ,  H01L29/423 ,  H01L29/66

Abstract: A self-healing field-effect transistor (FET) device is disclosed in this application, the self-healing FET has a self-healing substrate, a self-healing dielectric layer, a gate electrode, at least one source electrode, at least one drain electrode, and at least one channel. The self-healing substrate and the self-healing dielectric layer have a disulfide-containing poly(urea-urethane) (PUU) polymer. The self-healing dielectric layer has a thickness of less than about 10 µm. The electrodes have electrically conductive elongated nanostructures. The at least one channel has semi-conducting elongated nanostructures.

公开(公告)号：US20250000392A1

公开(公告)日：2025-01-02

申请号：US18699415

申请日：2022-10-25

Applicant: Technion Research and Development Foundation Limited

Inventor： Hossam HAICK ,  Youbin ZHENG ,  Rawan OMAR ,  Walaa SALIBA

IPC: A61B5/145 ,  A61B5/1473 ,  A61B5/1486

Abstract: The present disclosure provides a device and system for detecting and/or measuring a constituent of an interstitial fluid from the skin of a subject. The device is a wearable extended gate field effect transistor (EGFET) device comprising a polymeric substrate for fixing to the skin of the subject: an extended gate electrode comprising a first microneedle configured for accessing the interstitial fluid and a first electric contact, wherein the first microneedle and the first electric contact are disposed on the polymeric substrate; and a field effect transistor (FET) associated with the first microneedle through the first electric contact. Further provided are a method for detecting and/or measuring a constituent of an interstitial fluid from the skin of a subject involving the use of the system and a method for fabricating the EGFET device.

公开(公告)号：US20200232970A1

公开(公告)日：2020-07-23

申请号：US16486583

申请日：2018-02-21

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED

Inventor： Hossam HAICK ,  Weiwei WU

IPC: G01N33/497 ,  G01L19/00 ,  G01K7/18

Abstract: The present invention provides a vapor-permeable flexible sensing platform unit comprising: a first porous membrane, wherein said membrane is substantially flexible and hydrophobic; and a volatile organic compounds (VOCs) sensor disposed on said membrane, the VOCs sensor comprising an electrode array and a conducting polymer porous film being in electric contact with said electrode array, wherein the VOCs sensor is insensitive to lateral strain. Further provided are a method of preparation of said platform unit and a lift-off, float-on (LOFO) method for the preparation of protonically doped polyaniline (PANI) thin films.

公开(公告)号：US20220243014A1

公开(公告)日：2022-08-04

申请号：US17613826

申请日：2020-06-04

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED

Inventor： Hossam HAICK ,  Muhammad KHATIB

IPC: C08G75/14 ,  G01L1/22 ,  G01N27/414

Abstract: The present invention provides a solution-processable self-healing hydrolytically stable elastomer, a method for the preparation thereof, and articles of manufacture comprising the elastomer. The elastomer comprises polymeric chains comprising units of formula (A1), wherein R is a polybutadiene-containing polyurethane; R1 and R1′ are independently selected from the group consisting of: —H, (C1-C20)alkyl, (C5-C14)aryl, —OR4, —(CO)R5, —O(CO)R6, —(SO)R7, CO—R8, —COOR9, —NO2, and halogen; R2, R2′, R3 and R3′ are independently selected from the group consisting of: —H, (C1-C20)alkyl, and (C5-C14)aryl; R4 to R9 are the same or different, and are independently selected from the group consisting of: —H, (C1-C20)alkyl, and (C5-C14)aryl; m is 4; wherein the elastomer is dynamically crosslinked by aromatic disulfide metathesis, and wherein the elastomer has a water contact angle of above 100 #.

公开(公告)号：US20210263050A1

公开(公告)日：2021-08-26

申请号：US17183511

申请日：2021-02-24

Applicant: Technion Research and Development Foundation Limited

Inventor： Hossam HAICK ,  Yoav BROZA ,  Mamatha SERASANAMBATI ,  Dina HASHOUL ,  Walaa SALIBA

IPC: G01N33/84 ,  G01N33/574 ,  G01N30/72

Abstract: The present invention provides methods of detecting cell-to-cell signaling in cancer cells and methods of diagnosing, prognosing and monitoring cancer comprising the use of volatile organic compounds, which are indicative of cell-to-cell signaling in cancer cells.

公开(公告)号：US20210202748A1

公开(公告)日：2021-07-01

申请号：US17268628

申请日：2019-08-20

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED

Inventor： Hossam HAICK ,  Muhammad KHATIB

IPC: H01L29/786 ,  H01L29/06 ,  H01L29/423 ,  H01L29/16 ,  H01L29/24 ,  H01L29/66

Abstract: The present invention provides a self-healing field-effect transistor (FET) device comprising a self-healing substrate and a self-healing dielectric layer, said substrate and said layer comprising a disulfide-containing poly(urea-urethane) (PUU) polymer, wherein the dielectric layer has a thickness of less than about 10 μm, a gate electrode, at least one source electrode, and at least one drain electrode, said electrodes comprising electrically conductive elongated nanostructures; and at least one channel comprising semi-conducting elongated nanostructures. Further provided is a method for fabricating the FET device.