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公开(公告)号:US11458235B2
公开(公告)日:2022-10-04
申请号:US16466138
申请日:2017-12-05
IPC分类号: A61M1/16 , B01J39/17 , B01J20/02 , B01J20/24 , B01J47/02 , B01J47/04 , B01J20/20 , B01J39/12 , B01J41/10 , B01D15/08 , B01J47/024
摘要: The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.
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公开(公告)号:US20200078507A1
公开(公告)日:2020-03-12
申请号:US16466138
申请日:2017-12-05
IPC分类号: A61M1/16 , B01J39/17 , B01J20/02 , B01J20/24 , B01J47/024
摘要: The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.
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公开(公告)号:US20220401634A1
公开(公告)日:2022-12-22
申请号:US17892973
申请日:2022-08-22
IPC分类号: A61M1/16 , B01J39/17 , B01J20/02 , B01J20/24 , B01J47/024 , B01D15/08 , B01J47/04 , B01J20/20 , B01J39/12 , B01J41/10
摘要: The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.
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公开(公告)号:US09138524B2
公开(公告)日:2015-09-22
申请号:US14352283
申请日:2012-11-08
申请人: Temasek Polytechnic
发明人: Christian Gert Bluchel , Yanmei Wang , Hua Zhang , Jui Pin Er , Kim Jyh Wong
CPC分类号: A61M1/28 , A61M1/1609 , A61M1/1696 , B01D61/30 , G01N33/0021 , G01N33/0054 , G01N2001/1454 , G06F3/0202 , G06F3/033 , Y02A50/246
摘要: A sensing system for detecting a substance in a dialysate. The system includes a hydrophobic barrier capable of allowing the substance in the dialysate to equilibrate to a gas; a detector capable of detecting the gas; an interface disposed between the hydrophobic barrier and the detector and configured to allow fluid communication of the gas; and one or more delivery mechanisms capable of transporting the gas from the hydrophobic barrier to the detector. A method of detecting ammonium gas in a dialysate is also provided.
摘要翻译: 用于检测透析液中的物质的感测系统。 该系统包括能够使透析液中的物质平衡至气体的疏水屏障; 能够检测气体的检测器; 界面,设置在所述疏水屏障和所述检测器之间并且被配置为允许所述气体的流体连通; 以及能够将气体从疏水屏障传送到检测器的一个或多个输送机构。 还提供了一种检测透析液中的铵气体的方法。
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公开(公告)号:US11590272B2
公开(公告)日:2023-02-28
申请号:US16792774
申请日:2020-02-17
申请人: TEMASEK POLYTECHNIC
IPC分类号: A61M1/36 , A61M1/28 , B01J20/06 , B01J20/20 , B01J20/22 , B01J20/28 , B01J39/12 , B01J41/10 , A61M1/16 , B01D15/20 , B01D15/36
摘要: There is provided a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a layer of immobilized uremic toxin-treating enzyme particles intermixed with cation exchange particles.
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公开(公告)号:US20210205522A1
公开(公告)日:2021-07-08
申请号:US17209439
申请日:2021-03-23
申请人: TEMASEK POLYTECHNIC
摘要: A dialysis device is provided including a disposable housing having a flow path along which dialysate received from a patient is subjected to contaminant removal when in operation. The device includes a controller for controlling the operation of the disposable housing and an interface capable of operably coupling the controller and the disposable housing to enable the contaminant removal from the dialysate. The flow path is fluidly sealed from the controller and interface.
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公开(公告)号:US20180147338A1
公开(公告)日:2018-05-31
申请号:US15827341
申请日:2017-11-30
申请人: TEMASEK POLYTECHNIC
CPC分类号: A61M1/28 , A61M1/1658 , A61M1/1696 , A61M2205/121 , A61M2205/123 , A61M2205/126 , A61M2205/128 , A61M2205/33 , A61M2205/7518 , A61M2209/088
摘要: The present disclosure relates to dialysis devices. In some embodiments, a dialysis device may include a disposable housing having a storage chamber in fluid communication with a dialysate flow path. Also included may be a controller, an interface capable of operably coupling the controller and the disposable housing, a fluid displacement structure, a pump configured to actuate a deformable diaphragm, and a pressure sensor to trigger the reversal of the pump. The flow path may be fluidly sealed from the controller and the interface.
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公开(公告)号:US11135347B2
公开(公告)日:2021-10-05
申请号:US15827341
申请日:2017-11-30
申请人: TEMASEK POLYTECHNIC
摘要: The present disclosure relates to dialysis devices. In some embodiments, a dialysis device may include a disposable housing having a storage chamber in fluid communication with a dialysate flow path. Also included may be a controller, an interface capable of operably coupling the controller and the disposable housing, a fluid displacement structure, a pump configured to actuate a deformable diaphragm, and a pressure sensor to trigger the reversal of the pump. The flow path may be fluidly sealed from the controller and the interface.
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公开(公告)号:US20160109421A1
公开(公告)日:2016-04-21
申请号:US14833900
申请日:2015-08-24
申请人: Temasek Polytechnic
发明人: Christian Gert Bluchel , Yanmei Wang , Hua Zhang , Jui Pin Er , Kim Jyh Wong
IPC分类号: G01N33/00
CPC分类号: G01N33/0054 , A61M1/1694 , B01D61/24 , G01N1/2205 , Y02A50/246
摘要: A sensing system for detecting a substance in a dialysate. The system includes a hydrophobic barrier capable of allowing the substance in the dialysate to equilibrate through the barrier to a gas. The system also includes a detector capable of detecting the gas and an interface disposed between the hydrophobic barrier and the detector and configured to allow transport of the gas between the hydrophobic barrier and the detector following a concentration gradient of the gas along the interface.
摘要翻译: 用于检测透析液中的物质的感测系统。 该系统包括能够使透析液中的物质通过屏障平衡至气体的疏水屏障。 该系统还包括能够检测气体的检测器和设置在疏水屏障和检测器之间的界面,并被配置为允许气体沿着界面沿着气体的浓度梯度在疏水屏障和检测器之间传输。
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公开(公告)号:US10018607B2
公开(公告)日:2018-07-10
申请号:US14833900
申请日:2015-08-24
申请人: Temasek Polytechnic
发明人: Christian Gert Bluchel , Yanmei Wang , Hua Zhang , Jui Pin Er , Kim Jyh Wong
CPC分类号: G01N33/0054 , A61M1/1694 , A61M1/1696 , A61M1/28 , B01D61/24 , G01N1/2205 , Y02A50/246
摘要: A sensing system for detecting a substance in a dialysate. The system includes a hydrophobic barrier capable of allowing the substance in the dialysate to equilibrate through the barrier to a gas. The system also includes a detector capable of detecting the gas and an interface disposed between the hydrophobic barrier and the detector and configured to allow transport of the gas between the hydrophobic barrier and the detector following a concentration gradient of the gas along the interface.
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