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公开(公告)号：US11254644B2
公开(公告)日：2022-02-22
申请号：US16670676
申请日：2019-10-31
申请人： TES Pharma S.r.l.
IPC分类号： C07D239/38 , C07D403/12 , C07D233/68 , C07D233/84 , C07D233/96 , C07D407/12 , C07D409/12 , A61K31/505 , A61K31/513 , C07D239/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
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公开(公告)号：US20170362185A1
公开(公告)日：2017-12-21
申请号：US15612877
申请日：2017-06-02
申请人： TES Pharma S.r.l.
IPC分类号： C07D239/38 , A61K31/505 , C07D409/14 , C07D409/12 , C07D409/04 , C07D407/12 , C07D405/04 , C07D403/12 , C07D401/04 , C07D239/56 , C07D233/96 , C07D233/84 , C07D233/68 , A61K31/513 , C07D413/14 , C07D417/04
摘要： The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
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3.发明申请INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE 有权阿尔法 - 氨基 - 羧基果糖酸半胱氨酸脱羧酶的抑制剂公开(公告)号：US20160060226A1
公开(公告)日：2016-03-03
申请号：US14839209
申请日：2015-08-28
申请人： TES Pharma S.r.l.
IPC分类号： C07D239/38 , A61K31/513 , C07D409/04 , C07D405/04 , A61K31/505 , C07D417/04 , C07D413/14 , C07D409/14 , C07D239/56 , C07D401/04
CPC分类号： C07D239/38 , A61K31/505 , A61K31/513 , C07D233/68 , C07D233/84 , C07D233/96 , C07D239/56 , C07D401/04 , C07D403/12 , C07D405/04 , C07D407/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
摘要翻译： 本公开公开内容公开了能够调节α-氨基 - 羧甲基纤维素半醛脱羧酶（ACMSD）的活性的化合物，其可用于预防和/或治疗与NAD +生物合成缺陷相关的疾病和病症，例如， 代谢紊乱，神经变性疾病，慢性炎症性疾病，肾脏疾病以及与衰老有关的疾病。 本申请还公开了包含所述化合物的药物组合物和作为药物的这种化合物的用途。
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公开(公告)号：US10513499B2
公开(公告)日：2019-12-24
申请号：US15612877
申请日：2017-06-02
申请人： TES Pharma S.r.l.
IPC分类号： C07D239/38 , C07D403/12 , C07D233/68 , C07D233/84 , C07D233/96 , C07D407/12 , C07D409/12 , A61K31/505 , A61K31/513 , C07D239/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
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公开(公告)号：US09708272B2
公开(公告)日：2017-07-18
申请号：US14839209
申请日：2015-08-28
申请人： TES Pharma S.r.l.
IPC分类号： C07D239/38 , C07D403/12 , C07D233/68 , C07D233/84 , C07D233/96 , C07D407/12 , C07D409/12 , A61K31/505 , A61K31/513 , C07D239/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04
CPC分类号： C07D239/38 , A61K31/505 , A61K31/513 , C07D233/68 , C07D233/84 , C07D233/96 , C07D239/56 , C07D401/04 , C07D403/12 , C07D405/04 , C07D407/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
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