公开(公告)号：US09642859B2

公开(公告)日：2017-05-09

申请号：US14649272

申请日：2013-12-03

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Cara B. Gonzales

IPC: A61K31/55 ,  A61K9/19 ,  A61K45/06 ,  A61P35/00 ,  A61K9/00

CPC classification number: A61K31/55 ,  A61K9/0019 ,  A61K45/06

Abstract: Disclosed are methods and compositions for treating cancer, particularly for reducing cancerous cell growth, for example, in solid tumors. Disclosed methods and compositions include capsazepine (CPZ) or an analog of CPZ. Compositions comprising CPZ or an analog of CPZ may be useful for simultaneously treating cancer and alleviating pain by blocking TRPV1 channels.

公开(公告)号：US10457676B2

公开(公告)日：2019-10-29

申请号：US15505260

申请日：2015-08-25

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Cara B. Gonzales ,  Stanton McHardy

IPC: C07D471/04 ,  A61K31/55 ,  C07D233/16 ,  A61K31/472 ,  C07D209/44 ,  A61K31/5377 ,  C07D213/68 ,  A61K31/4745 ,  A61K31/17 ,  A61K45/06 ,  A61K31/155 ,  A61K31/165 ,  A61K31/4035 ,  C07D217/06 ,  C07D223/16 ,  C07C275/24 ,  C07C211/29 ,  C07C335/12 ,  C07C233/29 ,  A61P35/00

Abstract: The present disclosure relates generally to derivatives of capsazepine and methods of use thereof In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases. In some aspects of the present disclosure, the disclosure provides capsazepine derivatives which may be useful in the treatment of cancer. Such cancers that the compounds may be used to treating include but are not limited to breast, cervical, oral, head, neck, or prostate cancer. In some aspects, the compounds may be useful in treating a tumor by direct injection of the compound into the tumor, particularly an oral tumor. In other aspects, the compounds are administered systemically. The compounds of the present disclosure may also be used to treat the pain associated with a tumor for which it is being administered.